Described herein are methods using mechanical inverting tube apparatuses to remove clot (e.g., thrombectomy), the apparatuses including an inversion support catheter having an expandable funnel-shaped distal end, and a flexible tube that can be continuously rolled over the funnel-shaped distal end and invert into the inner lumen of the inversion support catheter.

An aspiration thrombectomy system is described with an aspiration catheter assembly having fittings interfaced with conduit and a pump. The aspiration catheter assembly can include a guide catheter and an aspiration catheter. The aspiration catheter can be positioned into an artery with a distal opening positioned proximal to a clot. The fittings can include a filter for removing thrombus from the aspiration flow. The fittings can include a flow meter for measuring flow to the pump. The fittings can include a pressure sensor for measuring pressure in the fittings. The aspiration catheter can be manipulated based on pressure and flow measurements. The fittings can include a docking manifold that can dock the connection suction of the suction extension to allow removal of the suction extension from hemostatic isolation and clearing of clots from the suction extension without further fittings such that the cleared suction extension can be efficiently reinserted for additional use.

An aspiration thrombectomy system is described with an aspiration catheter assembly having fittings interfaced with conduit and a pump. The aspiration catheter assembly can include a guide catheter and an aspiration catheter. The aspiration catheter can be positioned into an artery with a distal opening positioned proximal to a clot. The fittings can include a filter for removing thrombus from the aspiration flow. The fittings can include a flow meter for measuring flow to the pump. The fittings can include a pressure sensor for measuring pressure in the fittings. The aspiration catheter can be manipulated based on pressure and flow measurements. The fittings can include a docking manifold that can dock the connection suction of the suction extension to allow removal of the suction extension from hemostatic isolation and clearing of clots from the suction extension without further fittings such that the cleared suction extension can be efficiently reinserted for additional use.

An invasive electrohydraulic lithotripter probe may comprise a lithotripter tip that comprises a first electrode and a second electrode. The lithotripter tip has a length in excess of 250 cm and is dimensioned to be inserted into a long channel having a length in excess of 250 cm. The lithotripter probe may include a material that reinforces a linear strength of at least a portion of the lithotripter probe.

Electrohydraulic lithotripters comprising a plurality of electrohydraulic probes are disclosed. Each probe of the plurality of probes comprise a first electrode and a second electrode positioned at a distal end of the probe such that when the probe is discharged, an electric arc between the first electrode and the second electrode produces a shockwave that radiates from the distal end of the probe. A first probe and a second probe of the plurality of probes may be configured to discharge simultaneously or sequentially.

A histotripsy device may include a headset configured to be mounted to an about a cranium of a human or animal, at least one transducer mounted to the headset and positioned such that, with the headset mounted to and about the cranium, the at least one transducer is positioned over and in contact with at least one temporal or suboccipital region of the cranium, wherein the at least one transducer is configured to emit focused radiation in at an ultrasonic frequency or frequency range, at least one processor, and at least one memory having instructions stored therein executable by the at least one processor to cause the at least one processor to activate the at least one transducer to produce at least one pulse of ultrasonic radiation having a pulse duration of 1 milliseconds or longer.

Rolling tractor tube mechanical thrombectomy apparatuses that may be deployed from out of a catheter in situ are described herein. These apparatuses may be delivered out of a catheter from a collapsed delivery configuration within the catheter to a deployed configuration out of the catheter, in which the same catheter is re-inserted between a tubular tractor and an elongate puller. In particular, any of these methods and apparatuses may be adapted to work with a tractor tube having an open end that is biased open, including using an annular bias.

An assembly for placement of a cardiac, aortic or arterial implant. The assembly includes an insertion sheath of an introducer or of a delivery catheter, which is of a size smaller than that of an introducer, intended to be introduced into an artery of a human body. The metal support of an electrode of the external cardiac stimulator being integrated into the insertion sheath of a peripheral venous or arterial accessory catheter, or a sleeve around the accessory catheter, which is introduced into the peripheral vein or artery of a patient. The sheath of the accessory catheter or the sleeve is therefore directly in contact with a peripheral vein or artery of the patient.

An assembly for placement of a cardiac, aortic or arterial implant. The assembly includes an insertion sheath of an introducer or of a delivery catheter, which is of a size smaller than that of an introducer, intended to be introduced into an artery of a human body. The metal support of an electrode of the external cardiac stimulator being integrated into the insertion sheath of a peripheral venous or arterial accessory catheter, or a sleeve around the accessory catheter, which is introduced into the peripheral vein or artery of a patient. The sheath of the accessory catheter or the sleeve is therefore directly in contact with a peripheral vein or artery of the patient.

A medical device capable of adjusting, while a rotating expandable portion breaks an object, a breaking force of the expandable portion. The medical device for breaking a thrombus in a blood vessel includes a shaft portion, an expandable portion that is provided to the shaft portion, a fixing portion that fixes the expandable portion and the shaft portion, a slide portion that is fixed to the expandable portion and is slidable with the shaft portion, and an outer tube that houses therein the shaft portion, in which the slide portion is movable by being indirectly pressed by the outer tube, and the slide portion is relatively rotatable relative to the outer tube.