There is disclosed a method of treating affected external or surface tissue comprising the steps of providing a source of affected external or surface tissue; generating a source of microwave energy; transmitting said microwave energy into said affected external or surface tissues; exposing said affected external and surface tissues to said microwave energy to raise the local temperature to thereby ablate, remove, coagulate or otherwise alter said affected external and surface tissues. There is also disclosed an apparatus for the treatment of affected external and surface tissues comprising a microwave energy source generator, a means to transmit said microwave energy into said affected external or surface tissues, a means to control the exposure of said affected external and surface tissues to said microwave energy to raise the local temperature to thereby ablate, remove, coagulate or otherwise alter said affected external and surface tissues; and optionally a means to control the repetition of steps a) to d) multiple times until the ablation, removal, coagulation or otherwise alteration is complete, the period between each sequence of steps a) to d) being optionally cooled, and the location of said concentrated electric field being varied.

A surgical instrument end effector assembly includes a first jaw member defining an insulative tissue-contacting surface and first and second electrically-conductive tissue-contacting surfaces disposed on either side of the insulative surface. A second jaw member of the end effector assembly includes an ultrasonic blade body positioned to oppose the insulative surface of the first jaw member, and first and second electrically-conductive tissue-contacting surfaces disposed on either side of the ultrasonic blade body and positioned to oppose the first and second electrically-conductive surfaces, respectively, of the first jaw member. The first jaw member is movable relative to the second jaw member between a spaced-apart position and an approximated position to grasp tissue therebetween. The first and second electrically-conductive surfaces of the second jaw member are movable, independent of the first jaw member, relative to the first jaw member and the ultrasonic blade body between a retracted position and an extended position.

A medical device includes a thermal source that generates heat, a base that has an outer surface and to which the heat from the thermal source is transferred, a first coating that contacts one part of the outer surface of the base and a second coating that is provided on the outer surface of the base, and is exposed and electrically conductive. The second coating supplies, a high-frequency current to an object to be treated. The medical device also includes a laminated portion that includes the first coating in the outer surface of the base extends and a portion of the second coating that is laminated on the first coating.

A method for controlling an operation of an ultrasonic blade of an ultrasonic electromechanical system is disclosed. The method includes providing an ultrasonic electromechanical system comprising an ultrasonic transducer coupled to an ultrasonic blade via an ultrasonic waveguide; applying, by an energy source, a power level to the ultrasonic transducer; determining, by a control circuit coupled to a memory, a mechanical property of the ultrasonic electromechanical system; comparing, by the control circuit, the mechanical property with a reference mechanical property stored in the memory; and adjusting, by the control circuit, the power level applied to the ultrasonic transducer based on the comparison of the mechanical property with the reference mechanical property.

A tissue specimen removal device comprises a specimen bag; a flexible ring, the flexible ring configured to form a top opening of the specimen bag; a cannula assembly comprising: an inner tube portion and an outer tube portion. The device may further comprise a connector carrier, the connector carrier configured to retain at least one connector housing, the at least one connector housing comprising one or more connector portions and reside within an interior of the connector carrier, and wherein the connector carrier can be moved from a position within the cannula assembly to outside the cannula assembly.

A catheter system for ablation of tissue around a blood vessel, e.g., the pulmonary artery, to reduce neural activity of nerves surrounding the blood vessel. The catheter system includes an elongate shaft having a proximal portion coupled to a handle, and a distal portion. The distal portion includes a transducer and an expandable anchor, which may be actuated to transition between a collapsed delivery state and an expanded deployed state where the anchor centralizes the transducer within the blood vessel. The transducer may be actuated to emit energy to reduce neural activity of the nerves surrounding the blood vessel. Systems and method are further provided for confirming that neural activity of the nerves surround the blood vessel has been sufficiently reduced.

Provided herein are new compositions, methods, and devices to treat cancer through a combination of immunologic chemotherapeutic agents and ablation techniques. These compositions can include immune checkpoint inhibitors, cytokines and nucleic acid drugs that aid in eliciting an immune response to treat the tumor. The administration of these compositions in addition to various ablating techniques provides a presentation of the cancer cell antigens to the immune system and the immunologic targeting of the cancer.

This invention is directed to compositions and methods for treating a condition of the heart. In an embodiment, the invention is directed to a method of treating a subject in need thereof, wherein the method comprises ablating at least one nerve of the renal artery of the subject; and administering to the subject a therapeutically effective amount of cells.

A device for providing fractional treatment of a body orifice includes a source of fractionated energy and a source of electrical muscle (EMS) energy. A programmed controller controls the application of fractionated and/or EMS energy. A probe is inserted by its distal end into the body orifice. The source of fractionated energy is positioned for transmitting fractionated energy from the source of fractionated energy through the probe to tissue in the vicinity around the body orifice; and, the source of EMS is positioned for transmitting EMS energy from the source of EMS energy through the probe to tissue in the vicinity around the body orifice. The programmed controller is configured to control the activation of fractionated energy and EMS energy one of simultaneously or sequentially.

A method of operating a modular surgical system including a control module, a first surgical module, and a second surgical module is disclosed. The method includes detachably connecting the first surgical module to the control module by stacking the first surgical module with the control module in a stack configuration, detachably connecting the second surgical module to the first surgical module by stacking the second surgical module with the control module and the first surgical module in the stack configuration, powering up the modular surgical system, and monitoring distribution of power from a power supply of the control module to the first surgical module and the second surgical module.