A method and apparatus for pharmacy fulfillment and verification of non-sterile compounding. A system includes an entry node, the entry node including at least a processor, a memory and an input/output device, the memory including at least an operating system and an order entry process, and a pharmacy fulfillment and verification of non-sterile compounding system, the entry node communicatively linked to the pharmacy fulfillment and verification of non-sterile compounding system, the pharmacy fulfillment and verification of non-sterile compounding system including a set of components, the set of components including at least a formulating component, a fabrication component and a dispensing component.

Disclosed herein are methods for overfilling primary packaging components, and drug products prepared according to those methods. The methods may include introducing a volume of a formulated drug substance into a primary packaging component having a nominal volume, where the volume of the formulated drug substance is greater than the nominal volume of the primary packaging component. In some cases, the primary packaging component may be a prefillable syringe.

A sterile filling unit, of a basic container with contents that can be distributed in a fluid form and that is originally located in a source container in a sterile manner, includes a sterile chamber with at least one sterile entry port and/or outlet; a sterile fluid transfer and filling line with an intake and an outlet, such that for a filling stage the line passes through the wall of the sterile chamber in a sterile manner, with the intake located outside of the sterile chamber in sterile fluid communication with the source container, with the filling element at the outlet located inside the sterile chamber and positioned to be operating; and a unit that can introduce the disposable internal elements that, in a stage prior to the filling stage, were located outside of the sterile chamber, into the interior of the sterile chamber in a sterile manner.

A fluid dispenser device including a body; a reservoir containing one or two doses of a fluid, the reservoir including a stopper that closes the reservoir in leaktight manner before actuation; a dispenser head that is provided with a dispenser orifice; and dispenser mechanism for dispensing at least a portion of the fluid through the dispenser orifice during actuation. The device further includes a needle having a tip that is adapted to pierce the stopper during actuation, the reservoir being filled with the fluid and being closed with the stopper under a vacuum, so that the residual volume of air present in the reservoir between the fluid and the stopper is substantially zero.

In a method embodiment, an example method for simultaneously filling balloons with water, using an apparatus sufficiently compact to be operated while being held by hand, is disclosed. The method includes attaching the apparatus to a water supply. The apparatus includes a fitting comprising an inlet configured to connect to the water supply and a bulkhead joining the at least three branch assemblies. Each branch assembly includes a tube and an automatically-sealing balloon with a neck disposed around and removably attached to the tube. The method further includes simultaneously providing water from the attached water supply to each balloon of the balloon-filling apparatus. The method further includes detaching one or more of the balloons from the balloon-filling apparatus using a force comprising gravity each detached balloon and the water contained therein. Each detached balloon automatically seals upon detachment.

A method of providing a plurality of filled product bags of sterile fluid includes positioning a bag assembly onto a filling machine. The bag assembly includes a tube, a filter assembly, bladders, and stems. A stem is attached to a bladder, forms a fluid passageway, fluidly connects to the tube, and provides fluid communication into the bladders. The method includes fluidly coupling an inlet of the filter assembly to a connection line in fluid communication with a fluid source, and filling the bag assembly with a fluid. Filling the bag assembly includes passing the fluid through the filter assembly, the fluid passageway, and into the bladder. The method includes sealing the fluid passageway at a location between the tube and the bladders. The method includes cutting the stem to form a partially filled product bag having the sealed passageway. The method includes performing an integrity test on the filter assembly.

A pharmaceutical order filling system uses a physical parameter that occurs during attaching cap to a pharmaceutical container to determine if the cap is properly engaged. The physical parameter may be torque on the cap when placed on the container. An order processing device receives a pharmaceutical order and sends the order to a dispensing device that fills the container with a pharmaceutical in the pharmaceutical order. A cap device is configured to apply the cap the container containing the pharmaceutical from the dispensing device, wherein the cap device is configured to sense the physical parameter, e.g., torque, to the cap when applying the cap to the container.

A method of aseptically distributing fluid to a plurality of vessels includes securing the plurality of vessels relative to a hub and flowing fluid through an input tube into a plenum of the hub such that a substantially equal amount of fluid flows from the plenum into each of the vessels simultaneously. The vessels are positioned in the same plane relative to one another with each vessel having an inflow conduit extending from the hub to the vessel such that an arc segment is formed between the hub and the vessel.

An apparatus and method for aseptically filling a container utilizing an adaptor formed of severable and heat-sealable material connected to a tube and container. The adaptor includes a membrane which is unsealed to allow filling by a known filling machine. Once the adaptor tube and container is formed as a unit, it is sterilized. The adaptor is then severed and sealed, creating a usable aseptic liquid product.

The invention relates to a device (IO) for manually inserting a plunger-type stopper into a syringe cylinder, comprising a receptacle (18) designed to hold the syringe cylinder; a tubular barrel (30) designed to accommodate the plunger-type stopper in its interior, a holding device (28) designed to hold the barrel, and a moving device (40, 42, 44, 46, 48) designed to move the plunger-type stopper; the holding device (28) having an actuation portion (34) for moving the barrel (30) relative to the plunger-type stopper. The present invention further relates to a corresponding method.