The invention relates to a container precursor comprising a wall, wherein the wall a) surrounds an interior region, and b) comprises a first wall region and a second wall region; wherein the first wall region comprises a first layer sequence comprising a first wall layer, a second wall layer and a third wall layer as overlying layers from the interior region outwards; wherein, in the first wall region, a second carrier layer is characterised by a smaller layer thickness than a first carrier layer, or a third carrier layer, or both; wherein the second wall region comprises a second layer sequence comprising first wall layer, a second wall layer and a third wall layer as overlying layers from the interior region outwards; wherein, in the second wall region, the second wall layer is connected to the third wall layer; wherein, in the second wall region, the third carrier layer is characterised by a larger layer thickness than the first carrier layer, or the third carrier layer, or both. Further, the invention relates to a process for manufacturing a container precursor, a container precursor obtainable through this process, a closed container, a process for manufacturing a closed container, a closed container obtainable through this process, a use of the aforementioned container precursor, and a further use of the aforementioned container precursor.

The invention relates to a container precursor comprising a wall, wherein the wall a) surrounds an interior region, and b) comprises a first wall region and a second wall region; wherein the first wall region comprises a first layer sequence comprising a first wall layer, a second wall layer and a third wall layer as overlying layers from the interior region outwards; wherein, in the first wall region, a second carrier layer is characterised by a smaller layer thickness than a first carrier layer, or a third carrier layer, or both; wherein the second wall region comprises a second layer sequence comprising first wall layer, a second wall layer and a third wall layer as overlying layers from the interior region outwards; wherein, in the second wall region, the second wall layer is connected to the third wall layer; wherein, in the second wall region, the third carrier layer is characterised by a larger layer thickness than the first carrier layer, or the third carrier layer, or both. Further, the invention relates to a process for manufacturing a container precursor, a container precursor obtainable through this process, a closed container, a process for manufacturing a closed container, a closed container obtainable through this process, a use of the aforementioned container precursor, and a further use of the aforementioned container precursor.

A pharmaceutical product can be distributed to respective patients in a plurality of jurisdictions. First and second jurisdictions can have different labeling requirements than each other. A plurality of inner containers each store the pharmaceutical product, the pharmaceutical product being in a dosage form and in a package approved by each jurisdiction of the plurality. An inner container can be sealed within a first outer container including labeling required by the first jurisdiction and not required by the second jurisdiction. Another inner container can be sealed within a second outer container including labeling required by the second jurisdiction and not required by the first jurisdiction. The sealed first and second outer containers respectively can be distributed to the first and second jurisdictions.

A pharmaceutical product can be distributed to respective patients in a plurality of jurisdictions. First and second jurisdictions can have different labeling requirements than each other. A plurality of inner containers each store the pharmaceutical product, the pharmaceutical product being in a dosage form and in a package approved by each jurisdiction of the plurality. An inner container can be sealed within a first outer container including labeling required by the first jurisdiction and not required by the second jurisdiction. Another inner container can be sealed within a second outer container including labeling required by the second jurisdiction and not required by the first jurisdiction. The sealed first and second outer containers respectively can be distributed to the first and second jurisdictions.

Transport of containers for biologic products in secure thermal isolation may be facilitated by a containment apparatus. The containment apparatus may include a first component and a second component. The first component may comprise one or more sidewalls that may form an enclosed volume of the first component. The enclosed volume may be fluidly sealed from an environment surrounding the first component and at least partially filled with cooling media. The first component may comprise one or more recessed wells configured to receive at least part of individual containers. At least part of individual recessed wells may come into contact with cooling media within the enclosed volume to facilitate heat transfer between the cooling media and individual containers disposed in individual recessed wells.

Transport of containers for biologic products in secure thermal isolation may be facilitated by a containment apparatus. The containment apparatus may include a first component and a second component. The first component may comprise one or more sidewalls that may form an enclosed volume of the first component. The enclosed volume may be fluidly sealed from an environment surrounding the first component and at least partially filled with cooling media. The first component may comprise one or more recessed wells configured to receive at least part of individual containers. At least part of individual recessed wells may come into contact with cooling media within the enclosed volume to facilitate heat transfer between the cooling media and individual containers disposed in individual recessed wells.

A method for producing prick test single use sterile vials for use in a prick test is provided. The method comprises providing at least one allergen source including therewithin allergen extract, providing a plurality of single dose vials, connecting a tube to the at least one allergen source, connecting a metering device to the tube, drawing by the tube an amount of the allergen extract from one of the at least one allergen source, receiving the amount of allergen extract at the metering device, and dispensing by the metering device a volume of allergen extract into one of the plurality of single dose vials.

A method is described for shaping the bottom of hot-filled containers, in which the bottoms of the containers are forced inwardly from a state bulged outwardly, in particular as they cool down. Complex mechanisms for forcing the bottom inwardly are dispensable for the reason that the bottoms are forced inwardly by at least one fluid jet and/or fluid pressure wave. In addition, shaping the bottom can advantageously be carried out in a production region immediately downstream of a closer.

A method includes micro-machining a cavity within a substrate, filling the cavity with a medication, forming a sealing layer over the cavity, micro-machining a cantilevered beam from a layer of material, the cantilevered beam comprising a tip for puncturing the sealing layer, and attaching the cantilevered beam to the substrate such that moving the cantilevered beam toward the substrate enables the tip to puncture the sealing layer. A computer program product corresponding to the method is also disclosed. An apparatus includes a substrate having a cavity micro-machined therein, a sealing layer formed over the cavity, a medication disposed within the cavity, a cantilevered beam micro-machined from a layer of material, the cantilevered beam comprising a tip for puncturing the sealing layer, and the cantilevered beam attached to the substrate and disposed to enable the tip to puncture the sealing layer when the cantilevered beam is moved towards the substrate.

The present disclosure provides a medication package. The medication package may include a first medication stored in a first cavity and a second medication stored in a second cavity. The first medication may be selected, based on a geographical region, from a group of classes of medications. The second medication may be selected, based on the geographical region, from a group of classes of medications, wherein the class of the second medication is different than that of the first medication. The geographical region may be a contiguous region and may be defined by a common attribute.