Provided is a light detecting apparatus comprising a light emitting section that emits light; a light detecting section that detects light from an observation target irradiated with the light emitted by the light emitting section; a mount section attached to a test subject that includes the observation target; and a holding section that holds the light emitting section and the light detecting section and is detachably attached to the mount section. The holding section holds the light emitting section and the light detecting section in a manner to secure a relative positional relationship between the light emitting section and the light detecting section, and a relative positional relationship between the holding section and the mount section is determined by attaching the holding section to the mount section.

The invention provides a closed-loop spinal cord electrical stimulation system, including a spinal epidural electrical stimulation electrode, a low limb electrical stimulation electrode, a closed-loop electrical stimulator and a controller. The spinal epidural electrical stimulation electrode, the low limb electrical stimulation electrode and the controller are electrically connected to the closed-loop electrical stimulator respectively. The spinal epidural electrical stimulation electrode is used for applying a first electrical stimulation to the spinal epidural site, and the low limb electrical stimulation electrode is used for applying a second electrical stimulation to a low limb. The voltage of the first electric stimulation is 400-600 mV, the voltage of the second electric stimulation is 1 V-1.5 V, and the stimulation frequency of the both is 10-20 Hz. The stimulation system can send electrophysiological signals similar to sensorimotor neural circuitry to the subject with spinal cord injury, and can activate and remodel the neural circuit.

A system and method for testing an effect of light exposure on a skin sample include a solar simulator arranged to administer a combination of visible light (VL) and long wavelength ultraviolet radiation (UVA1) to the skin sample. The solar simulator includes a lamp for generating a light beam and at least one customized filter for receiving the light beam and emitting a VL+UVA1 spectral output having a wavelength range of 370-700 nm for irradiating the skin sample.

Apparatus for applying Transcranial Magnetic Stimulation (TMS) to a patient, the apparatus including a head mount for disposition on the head of a patient; and a plurality of magnet assemblies for releasable mounting on the head mount, wherein each of the magnet assemblies includes a magnet for selectively providing a rapidly changing magnetic field capable of inducing weak electric currents in the brain of a patient so as to modify the natural electrical activity of the brain of the patient; wherein the number of magnet assemblies mounted on the head mount, their individual positioning on the head mount, and their selective provision of a rapidly changing magnetic field is selected so as to allow the spatial, strength and temporal characteristics of the magnetic field to be custom tailored for each patient, whereby to provide patient-specific TMS therapy, to assist in diagnosis or to map out brain function in neuroscience research.

A method for assessing pain caused by administration of a drug solution includes: anesthetizing an experimental animal; inserting a measurement electrode into skeletal muscle of the anesthetized experimental animal; puncturing an injection needle into a predetermined part of the anesthetized experimental animal while measuring a myoelectric potential of the skeletal muscle with the measurement electrode; administering a drug solution to the anesthetized experimental animal; and (i) measuring a duration time of the myoelectric response caused by the administration of the drug solution, and/or (ii) measuring an EMG intensity obtained by integrating absolute values of myoelectric potentials during a period from occurrence of the myoelectric response by the administration of the drug solution to disappearance of the myoelectric response.

An illustrative system may include an extended reality system and a brain interface system configured to be concurrently worn by a user. The extended reality system may be configured to provide the user with an extended reality experience (e.g., an immersive virtual reality experience or a non-immersive augmented reality experience). The brain interface system may be configured to acquire one or more brain activity measurements while the extended reality experience is being provided to the user.

This disclosure relates to systems and methods for monitoring and classifying released gases in an enclosed system having a gas source, by a gas sensor that has been a priori pre-trained to distinguish an off-gas event (OGE) or a thermal run off event (TRE) from non-OGE interfering gases release. The pre-training utilizes one of a machine learning (ML) or a deep learning (DL) algorithm to pre-train the gas sensor to detect a plurality of known gas analyte to generate sensor signals with respective unique characteristics, extracting features from the sensor signals to establish a decision boundary or an estimated probability of a false positive release of the OGE or the TRE from the non-OGE type of interfering gas release. The established decision boundaries or probability distributions are implemented as candidate model for field deployment to classify the released gases to distinguish whether OGE or TRE takes place.

A method and system for detecting a position of an animal in laboratory conditions based on ultrasonic tracking is disclosed. The animal has an attached mobile device comprising an ultrasonic receiver. Ultrasonic signals emitted from ultrasonic emitters either have an envelope with a shape that is chosen with the first derivative restricted by condition |dE/dt|<A/T and/or with the second derivative restricted by condition |d.sup.2E/dt.sup.2|<A/T.sup.2, wherein E(t) is the envelope curve, t is time, A is the maximum amplitude of the ultrasonic signals and T is the period of the base frequency of the ultrasonic signals; or oscillations of voltage or current of ultrasonic emitters during signal transmission have envelopes described by a special function for amplitude of the oscillations. The mobile device receives an optical or radio synchronization signals from signal sources connected with the ultrasonic emitters. Analog or digital filters are used to separate ultrasonic signals from animal's vocalization. In some embodiments coordinates are obtained by using optical scanning sources with ultrasonic emitter placed at the axes of rotation of one or two emitted rotating planar scanning light beams. Tracking for multiple animals is disclosed.

Systems, methods and devices are implemented for microscope imaging solutions. One embodiment of the present disclosure is directed toward an epifluorescence microscope. The microscope includes an image capture circuit including an array of optical sensor. An optical arrangement is configured to direct excitation light of less than about 1 mW to a target object in a field of view of that is at least 0.5 mm.sup.2 and to direct epi-fluorescence emission caused by the excitation light to the array of optical sensors. The optical arrangement and array of optical sensors are each sufficiently close to the target object to provide at least 2.5 μm resolution for an image of the field of view.

A method of measuring efficacy of test treatment of an autoimmune disease in an animal in a vivarium is described. Animal activity data is collected at multiple times during the night. Sequential time regions of the night are identified as high-activity, activity-drop, or low-activity regions. Embodiments are described to quantify a drop, during the night, of an animal's activity level. These quantified activity-drop scalars for consecutive nights are accumulated in an animal health dataset. This dataset is compared to healthy animals, a standard of care or a reference treatment for the first disease to determine efficacy of the test treatment. One embodiment quantifies an activity-drop by fitting straight-line curves through the data in the three nightly regions. Other embodiment uses a Fourier transform on a circle, LASSO, RANSAC or regression analyses for curve fitting. Another embodiment compares areas under data curves in the regions. Animals may be housed in cages with other animals.