A closure for dispensing one or more active agents into a container comprises a sealed or sealable chamber having a breakable wall and a hollow piston slidably mounted in a piston guide. Said hollow piston comprises an outer wall having an end in the chamber and at least one ventilation aperture. Said end has a cutting formation. Said hollow piston is slidable in the piston guide between a ventilation position in which the at least one ventilation aperture allows ventilation of the chamber and a sealed position in which the at least one ventilation aperture is sealed to prevent ventilation of the chamber and a deployed position in which the cutting formation has broken through at least a portion of the breakable wall. The outer wall has a retaining formation which engages with the piston guide to releasably resist sliding of the hollow piston between the ventilation position and the sealed position and the deployed position. The hollow piston may have an outer wall, and said outer wall has an end within the chamber, facing the breakable wall, wherein the cutting end has a first edge having a cutting formation and a gap in said cutting formation.

A closure for dispensing one or more active agents into a container comprises a sealed or sealable chamber having a breakable wall and a hollow piston slidably mounted in a piston guide. Said hollow piston comprises an outer wall having an end in the chamber and at least one ventilation aperture. Said end has a cutting formation. Said hollow piston is slidable in the piston guide between a ventilation position in which the at least one ventilation aperture allows ventilation of the chamber and a sealed position in which the at least one ventilation aperture is sealed to prevent ventilation of the chamber and a deployed position in which the cutting formation has broken through at least a portion of the breakable wall. The outer wall has a retaining formation which engages with the piston guide to releasably resist sliding of the hollow piston between the ventilation position and the sealed position and the deployed position. The hollow piston may have an outer wall, and said outer wall has an end within the chamber, facing the breakable wall, wherein the cutting end has a first edge having a cutting formation and a gap in said cutting formation.

A closure for dispensing one or more active agents into a container comprises a sealed or sealable chamber having a breakable wall and a hollow piston slidably mounted in a piston guide. Said hollow piston comprises an outer wall having an end in the chamber and at least one ventilation aperture. Said end has a cutting formation. Said hollow piston is slidable in the piston guide between a ventilation position in which the at least one ventilation aperture allows ventilation of the chamber and a sealed position in which the at least one ventilation aperture is sealed to prevent ventilation of the chamber and a deployed position in which the cutting formation has broken through at least a portion of the breakable wall. The outer wall has a retaining formation which engages with the piston guide to releasably resist sliding of the hollow piston between the ventilation position and the sealed position and the deployed position. The hollow piston may have an outer wall, and said outer wall has an end within the chamber, facing the breakable wall, wherein the cutting end has a first edge having a cutting formation and a gap in said cutting formation.

Embodiments of a multi-compartment beverage bottle system and methods of manufacturing the system are disclosed. First and second housing elements are in mutual engagement with one another to at least partially define a fluid vessel with a fluid cavity therein. The fluid cavity includes a first fluid compartment and a second fluid compartment. The first housing element is rotatable between a storage position and a mix position with respect to the second housing element. A shuttle element is disposed within the fluid cavity and axially actuatable along the main axis into and out of a seal position. Rotation of the first housing element toward the storage position actuates the shuttle element toward the seal position. Rotation of the first housing element toward the mix position actuates the shuttle element away from the seal position, thereby placing the first and second fluid compartments into fluid communication with one another for mixing.

Embodiments of a multi-compartment beverage bottle system and methods of manufacturing the system are disclosed. First and second housing elements are in mutual engagement with one another to at least partially define a fluid vessel with a fluid cavity therein. The fluid cavity includes a first fluid compartment and a second fluid compartment. The first housing element is rotatable between a storage position and a mix position with respect to the second housing element. A shuttle element is disposed within the fluid cavity and axially actuatable along the main axis into and out of a seal position. Rotation of the first housing element toward the storage position actuates the shuttle element toward the seal position. Rotation of the first housing element toward the mix position actuates the shuttle element away from the seal position, thereby placing the first and second fluid compartments into fluid communication with one another for mixing.

A method of manufacturing a flexible container (1) housing a drug substance, comprises: forming a first compartment (11) of the container (1) out of a flexible sheet-like material, filling a liquid (2) into the first compartment (11) of the container (1), sealing the first compartment (11), forming a second compartment (12) of the container (1) out of the flexible sheet-like material, filling a dry drug formulation (3) into the second compartment (12), and sealing the second compartment (12). The method further involves lyophilizing the drug formulation inside a tubular cartridge such that the dry drug formulation (3) is generated and held in the tubular cartridge, wherein filling the dry drug formulation (3) into the second compartment (12) comprises: introducing the tubular cartridge holding the dry drug formulation (3) through an opening of the second compartment (12) of the container (1) such that an open end of the tubular cartridge is positioned distant from the opening of the second compartment (12), providing the dry drug formulation (3) out of the open end of the tubular cartridge into the second compartment (12), and withdrawing the tubular cartridge out of the opening of the second compartment (12) of the container (1). The first compartment (11) is separated from the second compartment (12) by a frangible seal (14) which opens when the first compartment (11) is compressed.

Embodiments of a multi-compartment beverage bottle system and methods of manufacturing the system are disclosed. First and second housing elements are in mutual engagement with one another to at least partially define a fluid vessel with a fluid cavity therein. The fluid cavity includes a first fluid compartment and a second fluid compartment. The first housing element is rotatable between a storage position and a mix position with respect to the second housing element. A shuttle element is disposed within the fluid cavity and axially actuatable along the main axis into and out of a seal position. Rotation of the first housing element toward the storage position actuates the shuttle element toward the seal position. Rotation of the first housing element toward the mix position actuates the shuttle element away from the seal position, thereby placing the first and second fluid compartments into fluid communication with one another for mixing.

The present invention relates to a device for transporting ready-cut and filled pieces of tube. In order to simplify the structural design of a device for transporting ready-cut and filled pieces of tube within a machine for producing double-chamber bags filled with brewable material, having a transport wheel, which has distributed over its circumference a plurality of double-chamber bag forming sets comprising a leading arm and a trailing arm and a profile part provided therebetween and being radially movable and supporting a bottom of a double-chamber bag, and which is rotatably mounted under a cover arranged in the vicinity of the upper vertex of the transport wheel, the present invention proposes that the arms are swivelably mounted eccentrically to the axis of rotation of the transport wheel and that the arms of adjacent double-chamber bag forming sets are swivelably mounted on a common swivel axis.

An assembly including a container having a first end and an opposing second end. The assembly also includes a housing for removably receiving a cartridge of the type including a substance storage compartment for storing a substance therein. The housing is connectable to the second end of the container. When connected to the container, the housing is movable relative to the container. A rupturing device is provided for rupturing the storage compartment upon relative movement between the housing and container, so as to combine any storage compartment contents with any container contents. The rupturing device is mounted within the container. A container opening is provided in the first end of the container; and a closure provided for sealing the container opening. The closure is movable between a closed position, and an open position for providing access to the container.

An assembly including a container having a first end and an opposing second end. The assembly also includes a housing for removably receiving a cartridge of the type including a substance storage compartment for storing a substance therein. The housing is connectable to the second end of the container. When connected to the container, the housing is movable relative to the container. A rupturing device is provided for rupturing the storage compartment upon relative movement between the housing and container, so as to combine any storage compartment contents with any container contents. The rupturing device is mounted within the container. A container opening is provided in the first end of the container; and a closure provided for sealing the container opening. The closure is movable between a closed position, and an open position for providing access to the container.