The invention relates to pharmaceutical formulations, and more particularly to formulations containing cannabinoids for administration via a pump action spray. In particular, the invention relates to pharmaceutical formulations, for use in administration of lipophilic medicaments via mucosal surfaces, comprising: at least one lipophilic medicament, a solvent and a co-solvent, wherein the total amount of solvent and co-solvent present in the formulation is greater than 55% wt/wt of the formulation and the formulation is absent of a self emulsifying agent and/or a fluorinated propellant.

A reusable dispensing container assembly, having a canister having a first end and a second end, the canister having an upper chamber to hold dispensable substance, an actuator arranged proximate the first end of the canister, in communication with the chamber, the actuator having a nozzle arranged to eject the dispensable substance, and, a deformable piston arranged within the canister below the upper chamber, the piston further arranged to sealingly engage an inner surface of the canister, the piston arranged for upward movement within the canister when the actuator is actuated, the deformable piston forming a lower chamber arranged to hold pressurized gas, the deformable piston comprising at least one integral external O-ring about its circumference arranged to sealingly engage the inner surface of the canister and maintain separation of the dispensable substance and the pressurized gas.

The disclosure relates to a pressurized Metered Dose Inhaler-compatible tablet, i.e. one that is able to be dispersed or disintegrates within a liquid phase propellant, which is used in a pressurized Metered Dose Inhaler formulation containing at least one active pharmaceutical ingredient and one or more excipients.

A double pressurized container 11, 31 includes an outer container 13, 33; an inner container 14, 34 stored inside the outer container 13, 33 and having flexibility; and a plug 15, 35 welded to the outer container 13, 33 and the inner container 14, 34 and sealing both of the outer container 13, 33 and the inner container 14, 34. An inside of the inner container 14, 34 is a concentrate chamber for charging a concentrate C, and a space between the outer container 13, 33 and the inner container 14, 34 is a pressurizing agent chamber for charging a pressurizing agent P, and the plug 15, 35 is provided with an openable seal part 15d, 44 to open the concentrate chamber. A discharge product 11a, 31a has the double pressurized container 11 filled with the concentrate C and the pressurizing agent P.

A pressurized dispensing system including a plastic bottle and a method of minimizing the formation of stress cracks in a plastic bottle that is a part of a pressurized dispensing system. In a method of manufacturing the pressurized dispensing system, a plastic bottle is filled with a liquid, a valve is crimped onto the plastic bottle, and the plastic bottle is filled with gas so as to pressurize the plastic bottle. The plastic bottle is supported only in the finish region throughout the liquid filling, valve crimping, and gas filling steps. The filled and pressurized plastic bottle is substantially free of stress cracks.

An apparatus is provided that is configured to be used with a container having contents to permit mixing of the contents of the container. The apparatus includes a main body having a geometrical shape having an open end, a closed end, and a longitudinally extending bore or opening extending from the open end to the closed end. The opening or bore is configured to receive at least a portion of a container. A shaft is generally orthogonally positioned from a portion of the closed end. The shaft is configured to be received by a rotational device. The mixing apparatus can be used to mix various sized containers containing contents having one or more materials to be mixed. The container is not attached to any portion of the main body and the container is configured to rotate freely and independently of the main body during an operation of the rotational device.

An aerosol dispenser, outer container for an aerosol dispenser and a preform for an outer container, each include an open neck at the top and a closed end bottom. The open neck may include a first surface having a first surface diameter, a second surface disposed interior to the first surface and having a second surface diameter less than the first surface diameter, and a transition distinguishing the first surface from the second surface. For a dispenser and a container, a product delivery device may be disposed on the second surface and not interfere with a valve operable by a user when the valve is attached to the open neck in engagement with the first surface. At least one of the first and the second surfaces may be a sealing surface to prevent escape of propellant from the outer container to ambient when a valve is attached.

The invention relates to pharmaceutical formulations, and more particularly to formulations containing cannabinoids for administration via a pump action spray. In particular, the invention relates to pharmaceutical formulations, for use in administration of lipophilic medicaments via mucosal surfaces, comprising: at least one lipophilic medicament, a solvent and a co-solvent, wherein the total amount of solvent and co-solvent present in the formulation is greater than 55% wt/wt of the formulation and the formulation is absent of a self emulsifying agent and/or a fluorinated propellant.

A reusable dispensing container assembly, having a canister having a first end and a second end, the canister having an upper chamber to hold dispensable substance, an actuator arranged proximate the first end of the canister, in communication with the chamber, the actuator having a nozzle arranged to eject the dispensable substance, and, a deformable piston arranged within the canister below the upper chamber, the piston further arranged to sealingly engage an inner surface of the canister, the piston arranged for upward movement within the canister when the actuator is actuated, the deformable piston forming a lower chamber arranged to hold pressurized gas, the deformable piston comprising at least one integral external O-ring about its circumference arranged to sealingly engage the inner surface of the canister and maintain separation of the dispensable substance and the pressurized gas.

The present invention provides a method for treating various skin diseases by topically administering to a subject a composition formulated as a foamable composition which includes a corticosteroid, such as halobetasol. The composition may include a corticosteroid, ethyl alcohol, emulsifying wax, cetostearyl alcohol, polyoxyl 20 cetostearyl ether, water, benzoic acid and propellant.