A flexible, sterilizable pouch includes a first gas-impermeable web, a second gas-permeable web, and the third gas-impermeable web. The webs are arranged and sealed to form a cavity portion of the pouch and a header portion of the pouch. The header portion of the pouch is gas-permeable through the second gas-permeable web. The cavity portion of the pouch is configured to hold a medical device for sterilization and is configured to be sealed from the header portion after sterilization, thereby making the cavity portion gas-impermeable. The header is also configured to be removed from the pouch, leaving the cavity portion.

A method for producing a sterilized oxygen-absorbing multilayer body is provided. The method may include: irradiating with radiation an oxygen-absorbing multilayer body comprising at least an oxygen-absorbing layer containing a transition metal catalyst and a thermoplastic resin (a) having a tetralin ring as a structural unit and a layer containing a thermoplastic resin (b); and heating the oxygen-absorbing multilayer body which has been irradiated with radiation in the sterilizing step at a temperature of the glass transition temperature of the thermoplastic resin (a) minus 20° C. or more and lower than the glass transition temperature of the thermoplastic resin (a) for 50 hours or more.

A method for producing a sterilized oxygen-absorbing multilayer body is provided. The method may include: irradiating with radiation an oxygen-absorbing multilayer body comprising at least an oxygen-absorbing layer containing a transition metal catalyst and a thermoplastic resin (a) having a tetralin ring as a structural unit and a layer containing a thermoplastic resin (b); and heating the oxygen-absorbing multilayer body which has been irradiated with radiation in the sterilizing step at a temperature of the glass transition temperature of the thermoplastic resin (a) minus 20° C. or more and lower than the glass transition temperature of the thermoplastic resin (a) for 50 hours or more.

A trouble recovering method of an aseptic filling machine and an aseptic filling machine which can resume operation at an early stage if a trouble occurs in any of portions during an operation of the aseptic filling machine are provided. A door of a chamber in which the trouble occurred is opened while a pressure in the chamber other than the chamber in which the trouble occurred is kept positive, the trouble is removed and then, the door is closed, an inside of the chamber in which the trouble occurred is cleaned as necessary, the inside of the chamber is sterilized and then, the operation of the aseptic filling machine is resumed.

A package comprising a first panel defining a first end, a second end opposite the first end, and at least two side edges; a second panel defining a first end, a second end opposite the first end, and at least two side edges, wherein the second panel is connected to the first panel via longitudinal seams formed along respective side edges of the first and second panels; and at least one end seam formed along at least one of the first end or the second end of the first and second panels, wherein the at least one end seam comprises an outer edge; and a barrier coating disposed on an interior surface of at least one of the first and second panels, wherein the barrier coating does not extend to the side edges of the longitudinal seams or the outer edge of the at least one end seam.

A package comprising a first panel defining a first end, a second end opposite the first end, and at least two side edges; a second panel defining a first end, a second end opposite the first end, and at least two side edges, wherein the second panel is connected to the first panel via longitudinal seams formed along respective side edges of the first and second panels; and at least one end seam formed along at least one of the first end or the second end of the first and second panels, wherein the at least one end seam comprises an outer edge; and a barrier coating disposed on an interior surface of at least one of the first and second panels, wherein the barrier coating does not extend to the side edges of the longitudinal seams or the outer edge of the at least one end seam.

A system is presented for monitoring and controlling in a sterilizable environment the peeling of a cover from a tub sealed by the cover. The system employs a platform having a fiducial source locating structure for holding the tub, a cover removal station disposed to engage with the cover and to peel the cover from the tub, a light source disposed to illuminate a portion of the platform proximate the cover removal station, a light sensor sensitive to light from the light source and disposed to preferentially collect and measure light diffusely reflected from the illuminated portion of the platform, and a controller with software to operate the system. An associated method for monitoring and controlling the peeling of the cover involves moving a peeled portion of the cover into a predetermined peeling monitor zone within the illuminated portion of the platform, and measuring an intensity of light from the light source diffusely reflected specifically from the peeling monitor zone. The positioning of the elements of the system and the peeling monitor zone allow measured light intensity to be employed as a control measure for the peeling process.

The present invention relates to an apparatus (10) for filling containers in a sterile environment, comprising a filling unit (40) configured to fill containers with sterilized liquids or powders in a sterile environment comprising interchangeable parts characteristic of each production run; a washer sterilizer (20) configured to wash, sterilize, decontaminate, dry in one single process said interchangeable parts of the filling unit (40) before each run for filling the unit (40). The washer sterilizer (20) is directly coupled to the filling unit (40) and is configured to aseptically transfer the interchangeable parts directly to the filling unit (40).

The present invention relates to a method and system for aseptically filling of flexible packages containing dry cloth. Such a method may include a first stage that is performed in a non-sterile environment. The first stage may include cutting a first substantially dry cloth to a predetermined size; inserting the first cloth into a flexible package; sealing a first end of the flexible package; and sterilizing the flexible package. The method may also include a second stage performed in a sterile environment. The second stage may include filling the flexible package with a medical solution such that the substantially dry cloth absorbs at least a portion of the medical solution; and sealing the open end of the flexible package.

A method for sterilizing closure elements (3) for packaging containers (1), wherein the closure elements (3) are collected individually by a holding mechanism (25) in the region of a sterile chamber (12) and are placed onto an opening (4) of a filled packaging container (1) and connected to the latter, and wherein the closure elements (3), while being conveyed inside the sterile chamber (12), are treated by means of at least one sterilizing medium (6, 7, 52) during a sterilizing process.