A safety device for a single-use mixing or storage system (10), especially for use in a biopharmaceutical process, includes a flexible bag (12) made from a film material and a support structure (14) receiving and supporting the bag (12) in several directions. The support structure (14) allows an expansion of the bag (12) in an expansion direction. The safety device further includes a detection unit (20) adapted to detect an expansion of the bag (12) in the expansion direction, and a control unit (28) connected to the detection unit (20) and adapted to initiate a safety measure in response to the expansion of the bag (12) in the expansion direction exceeds a given threshold.

A production line for manufacturing packaged products includes a plurality of workstations for performing different operations. Each of the workstations is configured to predictively determine time data during operation that define, as an interaction time, a time of an operator interaction with the respective workstation required in the future. The production line includes a central processing unit. The workstations are configured to transmit the time data to the central processing unit.

A control apparatus is provided. The control apparatus includes: a packaged medicine preparation unit discharging a bundle of packaged medicines in which a large amount of medicines are prepared by one capsule in a single dose to perform a post-process on the bundle of packaged medicines for a specific purpose based on a medicine dispensing request; and a post-processing unit introduced with the bundle of packaged medicines discharged from the packaged medicine preparation unit to perform the post-process thereon.

The packaging machine comprises a supply unit for holding and providing a plurality of package goods or packaging materials. A display device assigned to the supply unit is configured to display at least one optical marking, which is indicative of a fill level of the supply unit and is different from an alphanumeric display. The at least one optical marking is variably adaptable as a result of at least one process parameter different from the fill level in a way that an assignment of the at least one optical marking to a certain degree of the fill level of the supply unit is changeable. A control unit, which communicates with the display device, is configured to adapt the at least one optical marking as a function of the at least one process parameter different from the fill level.

The packaging machine comprises a supply unit for holding and providing a plurality of package goods or packaging materials. A display device assigned to the supply unit is configured to display at least one optical marking, which is indicative of a fill level of the supply unit and is different from an alphanumeric display. The at least one optical marking is variably adaptable as a result of at least one process parameter different from the fill level in a way that an assignment of the at least one optical marking to a certain degree of the fill level of the supply unit is changeable. A control unit, which communicates with the display device, is configured to adapt the at least one optical marking as a function of the at least one process parameter different from the fill level.

A method, apparatus and program product may utilize packaging material quality compensation to sense changes in certain characteristics of a packaging material that can be associated with increased risks of film breaks, and automatically make certain changes in machine settings to mitigate the impact of those enhanced risks.

A method, apparatus and program product may utilize packaging material quality compensation to sense changes in certain characteristics of a packaging material that can be associated with increased risks of film breaks, and automatically make certain changes in machine settings to mitigate the impact of those enhanced risks.

Item-management systems, apparatus, and methods are described, preferably for management of items such as medicaments. In embodiments, an item-management system comprises a container defining plural cells, a docking station configured to receive the container, sources of visible information to indicate the cell(s) into which an item is to be loaded, and at least one controller operable to control the visible information sources to indicate the cell into which the item is to be received.

Item-management systems, apparatus, and methods are described, preferably for management of items such as medicaments. In embodiments, an item-management system comprises a container defining plural cells, a docking station configured to receive the container, sources of visible information to indicate the cell(s) into which an item is to be loaded, and at least one controller operable to control the visible information sources to indicate the cell into which the item is to be received.

Disclosed are methods and apparatuses for manufacturing a solid formulation for oral administration, comprising an edible substrate portion on which a composition comprising a first pharmaceutical active ingredient is deposited, and solid formulations made thereby. The methods comprise providing an edible substrate in the form of a film comprising a plurality of portions, spraying a liquid formulation comprising the active ingredient and a solvent onto an edible substrate portion and evaporating the solvent to form a solid composition deposited on the edible substrate portion; measuring the quantity of active ingredient supported by the edible substrate portion and comparing to a predetermined value, and dividing the edible substrate into the plurality of portions.