The systems and methods of the present disclosure are used for guiding a medical instrument towards a target, the method positioning a medical instrument at a first location within a patient anatomy, wherein the medical instrument comprises at least one sensor, determining a first biomarker measurement using the at least one sensor, determining a second biomarker measurement using the at least one sensor, comparing the first biomarker measurement with the second biomarker measurement to determine a proximity to the target to provide a first comparison, and providing guidance for moving the medical instrument based on results of the first comparison.

Embodiments herein relate to systems, devices and methods for managing pharmacological therapeutics and aspects of the same. In an embodiment, a hearing assistance device can include a control circuit, an electroacoustic transducer for generating sound in electrical communication with the control circuit, a power supply circuit in electrical communication with the control circuit, and a sensor package in electrical communication with the control circuit. The control circuit can be configured to evaluate a signal from at least one of the sensors of the sensor package to detect administration of a therapy or receive data indicating that administration of a therapy has taken place. The control circuit can also be configured to record an instance of a detected medication administration event along with a timestamp. Other embodiments are also included herein.

A patient monitoring device configured to monitor cardiac activity and sleep stage information of a patient is provided. The device includes a plurality of electrodes to acquire electrocardiogram (ECG) signals from the patient, at least one motion sensor configured to generate a motion signal based upon movement of the patient, and at least one processor. The processor is configured derive motion parameters from the motion signal, derive ECG parameters from the ECG signals, determine whether the patient is in an immobilized sleep stage or a non-immobilized sleep stage based upon the motion parameters and the ECG parameters, adjust one or more cardiac arrhythmia detection parameters such that the device operates in a first monitoring and treatment mode when the patient is in an immobilized sleep stage, and monitor the patient for the cardiac arrhythmia using the first monitoring and treatment mode.

A monitoring system for monitoring a biological subject including a monitoring device having a housing configured to be attached to or supported by an ear of the subject in use, one or more sensors, the one or more sensors including a photoplethysmogram (PPG) sensor provided in the housing and configured to measure attributes of blood flow within the ear, and a monitoring device processor configured to acquire sensors signals from the one or more sensors and generate sensor data at least partially in accordance with signals from the one or more sensors. A transmitter is provided that transmit the sensor data with one or more processing systems receiving the sensor data, analyzing the sensor data and generating a health state indicator indicative of a health state of the subject.

A system for monitoring medical conditions including pressure ulcers, pressure-induced ischemia and related medical conditions comprises at least one sensor adapted to detect one or more patient characteristic including at least position, orientation, temperature, acceleration, moisture, resistance, stress, heart rate, respiration rate, and blood oxygenation, a host for processing the data received from the sensors together with historical patient data to develop an assessment of patient condition and suggested course of treatment, including either suspending or adjusting turn schedule based on various types of patient movement. Compliance with Head-of-Bed protocols can also be performed based on actual patient position instead of being inferred from bed elevation angle. The sensor can include bi-axial or tri-axial accelerometers, as well as resistive, inductive, capacitive, magnetic and other sensing devices, depending on whether the sensor is located on the patient or the support surface, and for what purpose.

An eyewear device, method for use with an eyewear device, and a non-transient computer readable medium for detecting blood sugar levels are disclosed. The eyewear device has a frame including a first rim configured to support a first lens, a second rim configured to support a second lens, and a bridge connecting the first rim to the second rim. The bridge is configured to receive a nose of a user when the eyewear device is worn by the user. Blood sugar levels are detected by monitoring behavior of a pupil of an eye of the user with a sensor, comparing the monitored behavior with known blood sugar level behaviors, identifying a match responsive to the comparison between the monitored behavior and one of the known blood sugar level behaviors corresponding to a particular blood sugar level, and selecting the particular blood sugar level as a blood sugar level of the user.

A digital pressure sensor includes a substrate, a pressure sensing structure configured for measuring a pressure of an object to be measured, a signal processing chip configured for receiving a sensing signal of the pressure sensing structure, and a rubber cover having an opening through which the pressure is sensed. The pressure sensing structure and the signal processing chip are mounted on the substrate. The signal processing chip has an analog-digital conversion module that converts the sensing signal output by the pressure sensing structure into a digital signal and outputs the digital signal. The signal processing chip is electrically connected to the substrate. The substrate and the rubber cover are connected to each other and form a mounting cavity for holding the pressure sensing structure and the signal processing chip.

Presented herein are systems and methods for measuring sweat rate of a subject using a wearable system. A sweat rate may be determined automatically based on one or more signals produced by a wetting sensor module in response to a presence of sweat in the wearable system. The one or more signals may be produced using a sweat presence monitoring device, for example comprising two or more electrodes that are operable to make conductance measurements. In some embodiments, sweat drops are periodically collected by the wearable system and individually detected by the wetting sensor module such that the sweat rate is determined based on the periodic detection of the drops. In some embodiments, an energy barrier is used to produce periodic flow of sweat through the wearable device detected by the wetting sensor module such that the sweat rate is determined based on the periodic flow.

A blood pressure measuring device includes a curler configured to bend along a circumferential direction of a wrist of a living body, and configured to come into contact with a portion of the wrist at least between a dorsal side and a palmar side; a strap provided to a device main body, and configured to cover an outer surface of the curler; a sensing cuff arranged in a region of the wrist where arteries exist; a back plate provided on a side of the sensing cuff nearer to the curler; a rubber plate provided on a side of the back plate nearer to the curler; a pressing cuff provided between the curler and the rubber plate; and a cuff provided on a side of the curler nearer to the living body and arranged on the dorsal side of the wrist.

There is disclosed herein examples of systems and methods of processing captured heart sounds with frequency-dependent normalization. Based on an amount of attenuation of a first heart sound, a second heart sound can be normalized by modifying portions of the second heart sound by amounts determined based on frequencies of the portions. Accordingly, the systems and methods disclosed herein can result in different amounts of modification of different portions of the second heart sound based on the different frequencies of the portions.