The present invention provides phase separation sensors capable of targeting or associating with one or more biomolecular condensate or membraneless compartment in cells. The phase separation sensors comprise at least two domains wherein a first domain comprises one or more accessory protein or molecule and a second domain comprises an artificial client protein or intrinsically disordered sequence. The artificial client protein possesses intrinsic disorder and is capable of engaging in ultra-weak phase separation-specific interactions with one or more component protein or molecule in a biomolecular condensate. Methods and applications utilizing the sensors are provided including targeting, detecting, visualizing, manipulating, monitoring a biomolecular condensate and delivering one or more functional protein, label, drug or agent to a biomolecular condensate.

A system includes a sensor applicator, a sensor control device arranged within the sensor applicator and including an electronics housing and a sensor extending from a bottom of the electronics housing, and a cap coupled to one of the sensor applicator and the sensor control device, wherein the cap is removable prior to deploying the sensor control device from the sensor applicator.

This inflatable balloon includes a balloon body, an inflation opening for the introduction of a fluid into the balloon body so as to inflate it under pressure, and at least one device for measuring a biological quantity of cavity tissues and/or of biological fluids present in this cavity. The measuring device includes an external sensor attached on an external face of the wall of the balloon body and adapted to supply an electrical measurement signal sensitive to the measured biological quantity, and an internal module located inside the balloon body and including a processing device adapted to process the electrical measurement signal in order to provide at least one measurement of the biological quantity.

A device configured to provide a faster and more accurate measurement of depths of holes for placement of bone screws and fastener for bone implant fixation procedures. The device includes a combination of a bone probe for physical examination of a hole drilled in a bone and a depth gauge member for determining a depth of the hole and providing digital measurement of the depth.

A pressure compensating non-invasive blood-component measuring device has electrically insulated parallel electrodes mounted on a dielectric membrane (106). A main circuit board (201) provides electrical connections to the electrodes and has an orifice (402) to allow flexing. A housing supports the main circuit board, with a second orifice to facilitate the application of a finger onto the insulated electrodes. A bottom circuit board (401) supports a force sensor (408) and fixing elements (313, 314) secure the bottom circuit board to the top circuit board, such that the bottom circuit board does not contact the housing directly. An intermediate board (316) is guided but not restrained by the fixing elements, and is arranged to apply force onto said force sensor.

The systems and methods of the present disclosure are used for guiding a medical instrument towards a target, the method positioning a medical instrument at a first location within a patient anatomy, wherein the medical instrument comprises at least one sensor, determining a first biomarker measurement using the at least one sensor, determining a second biomarker measurement using the at least one sensor, comparing the first biomarker measurement with the second biomarker measurement to determine a proximity to the target to provide a first comparison, and providing guidance for moving the medical instrument based on results of the first comparison.

A fastener according to the present disclosure includes a main unit, an adjuster unit which extends from the main unit and which is capable of being elastically inflected, and a cover unit coupled to the main unit through the adjuster unit. The cover unit is configured to be, by elastic flection of the adjuster unit, both in a state apart from the main unit and in a state latched with the main unit so as to cover the main unit, and with the cover unit being in the state latched with the main unit, a side surface of the main unit and a surface of the adjuster unit are apart from each other, the surface of the adjuster unit facing the side surface.

For control about a remote center of motion (RCM) of a surgical robotic system, possible configurations of a robotic manipulator are searched to find the configuration providing a greatest overlap of the workspace of the surgical instrument with the target anatomy. The force at the RCM may be measured, such as with one or more sensors on the cannula or in an adaptor connecting the robotic manipulator to the cannula. The measured force is used to determine a change in the RCM to minimize the force exerted on the patient at the RCM. Given this change, the configuration of the robotic manipulator may be dynamically updated. Various aspects of this RCM control may be used alone or in combination, such as to optimize the alignment of workspace to the target anatomy, to minimize force at the RCM, and/or to dynamically control the robotic manipulator configuration based on workspace alignment and force measurement.

The technology provides a multi-body earpiece suitable for use as an in-ear sensor system, which can be used for biometrics or a human-computer interface. The multi-body earpiece includes two body elements connected together by a flexure. These components provide at least 3 points of contact along different parts of the outer ear, in which the flexure is tethered to the two bodies and arranged to lock them in place during wear. In addition to having stability from moving while minimizing sound occlusion, this arrangement enables any electrodes for the on-board sensor(s) to remain in contact with the skin of the ear, and provide as many contact points in desired areas as the electronics dictate for the signals of interest.

A body motion sensor according to the present disclosure includes one or a plurality of detecting units which is placed in a casing attachable so as to be in contact with a body, and which is capable of detecting a body situation, and a control unit capable of controlling a transmission of information to an external device based on a detection signal from the detecting unit. The detecting unit includes at least an optical sensor. The control unit determines a contact state of the casing with the body of a wearing person in accordance with the detection signal from the optical sensor, and decides an information content to be transmitted to the external device based on the detection signal from the detecting unit in accordance with a determination result.