Multifunctional wireless apparatus, spectrometry instruments, real-time computational system and device ergonomic forms for live and telemetry monitoring of clinical parameters, health data and other vital medical information. Clinical parameters and medical information include pulse rate, respiratory rate, continuous blood glucose levels, continuous blood pressure levels, pulse rate variability, oxygen saturation ratio, body temperature, bio-electrical activity, sleep patterns, sleep health and other vital bio-signal data. The telemetry apparatus encompasses electrical and optical spectrometer instruments. The spectrometer designs and its accompanying circuit design ensure that device is bio-safe, lightweight, low-powered and portable. The bio sensor configuration, comprehensive hardware design, computational process and ergonomic design enables the measurement with more accuracy and efficiency, even in movement artefact prone conditions. The system design also assures that the computational process is real-time, faster and low powered. The wireless apparatus keeps track of the user information on daily diet pattern, fluid and water intake, exercise intensity, other essential health data, and provides necessary alerts. The apparatus yields persona-oriented stress levels and helps the user manage stress through guided practices. The health management system functions based on the user inputs and previously computed parameters. An automated life-support functionality is integrated in the system, that can forecast chronic clinical conditions and health risks like sleep apnea, hypertension, hypoglycemia, hyperglycemia, hypothermia, hyperthermia, CO poisoning, fatigue conditions and more.

A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor substrate, electrode or housing, an analyte indicator covering at least a portion of the sensor, and one or more compounds that reduce degradation of the analyte indicator.

Devices associated with on-body analyte sensor units are disclosed. These devices include any of packaging and/or loading systems, applicators and elements of the on-body sensor units themselves. Also, various approaches to connecting electrochemical analyte sensors to and/or within associated on-body analyte sensor units are disclosed. The connector approaches variously involve the use of unique sensor and ancillary element arrangements to facilitate assembly of separate electronics assemblies and sensor elements that are kept apart until the end user brings them together.

The present disclosure relates to a continuous glucose monitoring biosensor, and more specifically, to: a biosensor which controls the flow of blood glucose flowing into a body during implantation, thereby enabling continuous detection and quantification of the blood glucose with high sensitivity; and a continuous glucose monitoring device and method using same. When a polymer blend composition including a hydrophilic polymer and a hydrophobic polymer according to the present disclosure, a diffusion control membrane formed therefrom and a continuous glucose monitoring biosensor including the same are used, they have the advantage capable of controlling an excessive influx of blood glucose due to an increase in the rate of diffusion in the sensor, thus enabling manufacture of a sensor having excellent accuracy and durability.

A wearable device includes one or more sensors of information from a subject. The wearable device may have an electronic assembly supported by a base. The electronic assembly may include a sensor data collection system configured to control collection of sensor data related to one or more characteristics of a subject and one or more processors. the sensor data collection system may include a controller configured to control sequencing and scheduling of the sensor data collection, and a buffer configured to receive and buffer data corresponding to the sensor data collected from the one or more sensors in accordance with a signal provided by the controller. The one or more processors may be configured to receive the buffered data from the buffer in accordance with a wake signal; process the received data; and output the processed data. Scheduling and sequencing the sensor data collection by the sensor data collection system may be decoupled from the processor such that the processor may be in a low-power sleep mode during data collection and in a normal power mode to process data received from the buffer.

An implantable medical device, battery and method include memory configured to store program instructions. At least one of circuitry or a processor are configured to execute the program instructions in connection with at least one of monitoring a biological signal or administering a therapy. The device includes a battery comprising a cell stack that includes an anode, a cathode, and one or more separator layers electrically insulating the anode from the cathode. The device includes a case having a feedthrough port and a feedthrough assembly disposed in the feedthrough port. The feedthrough assembly includes a ferrule having a lumen. An inner conductor is disposed within the lumen of the ferrule. The inner conductor is formed from a material having a first composition and a first coefficient of thermal expansion (CTE). An insulating core is disposed within the lumen of the ferrule and separates the inner conductor from the ferrule. The insulating core is formed from a material having a second composition and a second CTE. The first CTE of the inner conductor is equal to or greater than the second CTE of the insulating core and the first and second compositions are molecularly bonded with one another to form a hermetic seal between the inner conductor and the insulating core.

A measuring arrangement for in-vivo determination of the lactate concentration in blood by means of electrochemical impedance spectroscopy, comprising a substantially flat shaped probe having a longitudinal extension, a transverse extension and a thickness, wherein the longitudinal extension and the transverse extension of the probe are each a multiple of the thickness of the probe, an analyzer circuitry connected to the probe, and communication means connected to the analyzer circuitry for transferring data via a WPAN, wherein the substantially flat shaped probe is arranged at an edge of the measuring arrangement, so that the probe, during operation of the measuring arrangement, faces the animal or human body to be examined, in such a manner that the probe is arranged with its longitudinal and transverse extensions approximately parallel to the surface of the body to be examined, a wristband therefor, and a method for the operation thereof.

Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.

Disclosed is a five-degree-of-freedom (5-DOF) therapeutic focus positioning device for magnetic resonance guidance, including: a driving bed body, a working bed body and an auxiliary bed body; the working bed body is provided with a probe connection plate and a probe movement control assembly for controlling the probe connection plate to perform a multi-degree-of-freedom movement, and the probe connection plate is provided with an ultrasonic probe; the probe movement control assembly includes a mechanism moving front and rear of the probe, a mechanism moving left and right of the probe, a rotation mechanism of the probe, a mechanism moving up and down of the probe and a swinging mechanism of the probe; and the driving bed body is provided with a motor variable speed group for driving the probe movement control assembly.

A finger insert for use with a nailfold imaging device includes a housing to receive the user's finger and an immersion substance (e.g., immersion oil), and a deformable pad that holds the user's finger in place during imaging, as well as prevent bubble formation in the substance. The housing includes a transparent wall to facilitate imaging of the finger. The transparent wall includes multiple angled portions that prevent or reduce contact between the nailfold and the wall, to ensure sufficient blood flow through the nailfold region for imaging.