A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards eukaryotic cells are provided. Also provided are chemical and chemo-enzymatic processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders.

An organization and storage system and method including a hang tag piece for attachment to an object to be organized and stored and a case configured for receiving and housing the object and hang tag piece. In an exemplary embodiment, the present invention is utilized for organizing and storing flash drives. The hang tag piece includes an end slot opening leading to an inner cavity; a label; a side display configured for displaying the label within the inner cavity; a protector piece configured for protecting the label; and attachment holes on each end. The case includes an open internal space for receiving and holding the object to be organized and stored and attached hang tag piece and further includes a case label corresponding to the hang tag label and object to be organized and stored.

An assembly for mounting at least one component in a tank for a motor vehicle, the tank including a wall portion and an attachment portion projecting outward from the wall portion, the attachment portion defining an opening in the wall portion, the assembly including: a mounting module configured to carry the at least one component and to close the opening in the wall portion; the mounting module including an outer side configured to be accessible from outside the tank; at least one connector arranged on the outer side of the mounting module, the at least one connector being connected to the at least one component; a clamp configured to clamp the mounting module to the attachment portion; and a cover attached to the clamp and covering at least partially the at least one connector.

A unitary, single-use, sanitary seal for a beverage can. It has a number of redundant sealing interfaces incorporated into its design and uses of both friction fit and captive seals. It may be installed at the canning facility or elsewhere by a third party, with or without the use of heating. Its dome construction flexes the side walls and seals outward in an expansive manner to allow installation. To remove, the seal must be destroyed, leaving a visual indication. It allows a conventional six-pack ring to be used as well as the vertical stacking of groupings of cans. Antibacterial agents such as silver, copper, zinc, tin, or the like may optionally be incorporated into the seal's material to enhance or maintain sterility.

A unitary, single-use, sanitary seal for a beverage can. It has a number of redundant sealing interfaces incorporated into its design and uses of both friction fit and captive seals. It may be installed at the canning facility or elsewhere by a third party, with or without the use of heating. Its dome construction flexes the side walls and seals outward in an expansive manner to allow installation. To remove, the seal must be destroyed, leaving a visual indication. It allows a conventional six-pack ring to be used as well as the vertical stacking of groupings of cans. Antibacterial agents such as silver, copper, zinc, tin, or the like may optionally be incorporated into the seal's material to enhance or maintain sterility.

Articles of manufacture, products, and packaging methods are provided that include a label with a tear strip. A labeled container includes a base, a lid, and a label sealing the base to the lid. The base includes a bottom wall and a base side wall. The lid includes a top wall and a lid skirt. The lid mates with the base to define an interior space. The label has a front face and a rear face. The label includes an outer web including polymer film, paper, or a combination thereof and an inner web of polymer. A tear strip is defined in the inner web by one or more weakened portion, score lines, or cuts in the inner web. The rear face of the label is adhesively bonded to the base side wall and to the lid skirt to form a seal between the base and the lid. The tear strip is positioned between a portion of the label adhesive bonded to the base side wall and a portion of the label adhesively bonded to the lid skirt. The tear strip can be used to open the container.

The present invention is directed to, in part, fused heteroaryl compounds and compositions useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. For example, such compounds include those having the structure: ##STR00001## or pharmaceutically acceptable salts thereof. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel, including Dravet syndrome or epilepsy, using such compounds are also provided herein.

A basket for lining an ice chest includes four flexible walls configured to roll up, a bottom, and at least two handles. At least one wall includes perforations configured to allow water or ice to pass through the perforations. The four flexible walls are made of silicone, rubber, elastic, or any combination thereof.

A basket for lining an ice chest includes four flexible walls configured to roll up, a bottom, and at least two handles. At least one wall includes perforations configured to allow water or ice to pass through the perforations. The four flexible walls are made of silicone, rubber, elastic, or any combination thereof.

The present invention is generally related to product packaging, and more particularly to a product packaging having an external sample of the product contained within the packaging and a method of making the product packaging. The present invention is directed to exemplary embodiments of a product packaging having an external sample of the product contained within the packaging. The product packaging is configured to provide a representation of the product contained within the packaging in the product's final and/or applied form. The product packaging may include a product sample swatch that is configured to affixation to a product container containing the product represented by the sample swatch in its non-final form. The present invention is also directed to exemplary embodiments of a method for affixing a product sample swatch to a product container containing the product represented by the sample swatch in its non-final form.