A packaging system includes a base, a lid, a closure structure, and an adhesive deposit. The base has a well. The lid is hingeably connected to the base and has a user input region and a protrusion projecting into the well. The closure structure is configured for releasably retaining the lid in a closed position relative to the base. The adhesive deposit is located within the well and at least partially surrounds the protrusion, and forms a first plurality of adhesive bonds with the well and a second plurality of adhesive bonds with the protrusion. The second plurality of adhesive bonds and the closure structure are configured to exert a combined retention force of at least 20N.

The disclosure relates to forming shaped thermoplastic articles having smooth peripheries. Many thermoplastic articles have sharp edges formed upon molding or cutting the article from a feedstock sheet. Such sharp edges can damage thin plastic films or flesh which they contact, and smoothing the edges is desirable. Described herein are methods of forming a smooth periphery for such sharp-edged articles by rolling over the sharp edge. The smoothing operation is performed by forming a deflectable flange including a bend region separated from the potentially sharp peripheral edge by a spacer, deflecting a portion of the deflectable flange, and softening at least one bent portion of the deflectable flange to yield a smooth periphery upon cooling.

The disclosure relates to forming shaped thermoplastic articles having smooth peripheries. Many thermoplastic articles have sharp edges formed upon molding or cutting the article from a feedstock sheet. Such sharp edges can damage thin plastic films or flesh which they contact, and smoothing the edges is desirable. Described herein are methods of forming a smooth periphery for such sharp-edged articles by rolling over the sharp edge. The smoothing operation is performed by forming a deflectable flange including a bend region separated from the potentially sharp peripheral edge by a spacer, deflecting a portion of the deflectable flange, and softening at least one bent portion of the deflectable flange to yield a smooth periphery upon cooling. A liner sheet may be attached to the feedstock sheet prior to, during, or after forming and can be peelable therefrom.

The present disclosure relates to pouches made from a combination of chemically different water-soluble films and optionally containing a composition (e.g. a household care composition or non-household care composition) that is at least partially enclosed by the water-soluble films in at least one compartment.

The present disclosure relates to pouches made from a combination of chemically different water-soluble films and optionally containing a composition (e.g. a household care composition or non-household care composition) that is at least partially enclosed by the water-soluble films in at least one compartment.

A sealant releasably seals a distal end of a tip of a tube containing a curable substance dispensable from the tip of the tube. The sealant has between about 20 N and about 60 N of penetration resistance force in a penetration resistance test, wherein the penetration resistance test comprises: (i) placing the sealant in a container at room temperature such that the sealant has a top surface defining a plane; (ii) attaching a conical probe to a force gage wherein the conical probe has a tip length of 7.5 mm, a diameter of 9 mm, and an overall length of 20 mm; (iii) moving the conical probe perpendicularly relative to the plane of top surface of the sealant; and (iv) inserting the conical probe into the sealant to an insertion depth of between 8 mm and 12 mm to generate the penetration resistance force.

Disclosed is a deodorant dispenser refill cartridge, comprising: a container defining a chamber storing a fluid deodorant composition and having an opening through which the composition is dispensable from the chamber; and a seal sealing the opening. Also disclosed is a deodorant dispenser, comprising: a body having a cavity for receiving a first portion of the refill cartridge; a device within the cavity and extending along at least a portion of an edge region of the cavity for puncturing the seal of the refill cartridge as the first portion of the refill cartridge is received in the cavity of the body; and an applicator for applying the fluid deodorant composition to a user at an exterior of the dispenser.

Disclosed is a deodorant dispenser refill cartridge, comprising: a container defining a chamber storing a fluid deodorant composition and having an opening through which the composition is dispensable from the chamber; and a seal sealing the opening. Also disclosed is a deodorant dispenser, comprising: a body having a cavity for receiving a first portion of the refill cartridge; a device within the cavity and extending along at least a portion of an edge region of the cavity for puncturing the seal of the refill cartridge as the first portion of the refill cartridge is received in the cavity of the body; and an applicator for applying the fluid deodorant composition to a user at an exterior of the dispenser.

Shape-stabilized collagen scaffolds and methods of obtaining such stabilized scaffolds are disclosed. Stroma can be harvested, for example, from human or porcine corneal stroma. The stroma can be shaped during excision or in a separate step after excision. Following shaping (and preferably decellularization), the excised stroma portion is subject to pressure, force or vacuum to reduce fluid content and then irradiated or otherwise treated to induce crosslinking of collagen chains or fibrils. Various sources of energy can be employed to induce peptide bond crosslinking of collagen including, for example, ultraviolet (UV) radiation. The scaffolds can also be selectively densified or patterned. The invention is particularly useful in forming stable lenticules for intracorneal implantation in additive ocular surgery.

Shape-stabilized collagen scaffolds and methods of obtaining such stabilized scaffolds are disclosed. Stroma can be harvested, for example, from human or porcine corneal stroma. The stroma can be shaped during excision or in a separate step after excision. Following shaping (and preferably decellularization), the excised stroma portion is subject to pressure, force or vacuum to reduce fluid content and then irradiated or otherwise treated to induce crosslinking of collagen chains or fibrils. Various sources of energy can be employed to induce peptide bond crosslinking of collagen including, for example, ultraviolet (UV) radiation. The scaffolds can also be selectively densified or patterned. The invention is particularly useful in forming stable lenticules for intracorneal implantation in additive ocular surgery.