A ready-to-administer antioxidant free phenylephrine compositions has improved stability and is optionally free of metal chelating agents. Contemplated compositions are preferably packaged into a flexible polymer bag and maintain degradation of the phenylephrine at remarkably low levels, even over extended storage periods.

A film for a secondary packaging includes a first ply, a second ply, and a third ply. The first ply includes a polyolefin and the third ply includes a plastic. A first adhesive layer bonds the first ply and the second ply and a second adhesive layer bonds the second ply and the third ply. An oxygen barrier layer is between the first adhesive layer and the second adhesive layer. The oxygen barrier layer includes at least one of a metal oxide or a metalloid oxide. A primary packaging filled with a medical liquid can be arranged in the secondary packaging. A method for manufacturing a medicine product including the primary packaging arranged in the secondary packaging is also described.

A film for a secondary packaging includes a first ply, a second ply, and a third ply. The first ply includes a polyolefin and the third ply includes a plastic. A first adhesive layer bonds the first ply and the second ply and a second adhesive layer bonds the second ply and the third ply. An oxygen barrier layer is between the first adhesive layer and the second adhesive layer. The oxygen barrier layer includes at least one of a metal oxide or a metalloid oxide. A primary packaging filled with a medical liquid can be arranged in the secondary packaging. A method for manufacturing a medicine product including the primary packaging arranged in the secondary packaging is also described.

A ready-to-administer antioxidant free phenylephrine compositions has improved stability and is optionally free of metal chelating agents. Contemplated compositions are preferably packaged into a flexible polymer bag and maintain degradation of the phenylephrine at remarkably low levels, even over extended storage periods.

A ready-to-administer antioxidant free phenylephrine compositions has improved stability and is optionally free of metal chelating agents. Contemplated compositions are preferably packaged into a flexible polymer bag and maintain degradation of the phenylephrine at remarkably low levels, even over extended storage periods.