This invention provides a method of treating a patient afflicted with a neurodegenerative disorder, e.g., Huntington's disease (HD), comprising administering to the patient laquinimod as an add-on therapy to or in combination with pridopidine. This invention also provides a package and a pharmaceutical composition comprising laquinimod and pridopidine for treating a patient afflicted with a neurodegenerative disorder, e.g., HD. This invention also provides laquinimod for use as an add-on therapy or in combination with pridopidine in treating a patient afflicted with a neurodegenerative disorder, e.g., HD. This invention further provides use of laquinimod and pridopidine in the preparation of a combination for treating a patient afflicted with a neurodegenerative disorder, e.g., HD.

The present invention provides composition, apparatus, kit and method for compounding an orally administered dosage form of at least one medicament comprising a container for mixing a crushed medicament with a gel-based carrier. The container comprises at least one chamber and at least one membrane as a separating element. The container comprises a flexible membrane, when removed or partially broken, provides a mixture of a defined dosage form of said medicament comprising the crushed medicament and said gel-based carrier. The membrane is further configured to prevent contamination, overdosing and non sanctioned abuse of active ingredient of said medicament.

The present invention provides composition, apparatus, kit and method for compounding an orally administered dosage form of at least one medicament comprising a container for mixing a crushed medicament with a gel-based carrier. The container comprises at least one chamber and at least one membrane as a separating element. The container comprises a flexible membrane, when removed or partially broken, provides a mixture of a defined dosage form of said medicament comprising the crushed medicament and said gel-based carrier. The membrane is further configured to prevent contamination, overdosing and non sanctioned abuse of active ingredient of said medicament.

This invention provides a thin and discreet coolant device, and single and multiple unit dispenser containers containing the same. The coolant device comprises a first packet being comprised of a waterproof or water-resistant material containing water therewithin and further comprising a fold and further adapted to have a selectively permanent connection between external and internal layers of said fold, such that upon applying a force to laterally extend the ends of said packet, a rupture of said first packet occurs allowing for the leakage of the water contained therewithin. The coolant device further comprises a second packet which encases said first packet, comprising an exterior and interior layer, wherein said interior layer is comprised of an absorbant material and said exterior layer is comprised of a waterproof or water-resistant material and wherein an amount of powdered urea is located within an interior of said second packet. Upon lateral extension of the sides of the second packet, a rupture of said first packet occurs allowing for the leakage of the water contained therewithin and its exposure to said urea located within said second packet, which exposure results in an endothermic reaction resulting in an outer surface of said second packet becoming cooler to the touch than an outer surface temperature prior to said rupture. Use of the coolant devices to provide cooling to a skin surface on demand is described, as well.

A dispenser actuator assembly (100) actuates a dispenser (10). The dispenser (10) is a plastic ampoule (10) having a container (48) having an outer wall (50) and membrane (52) collectively defining a first chamber (54) containing a flowable material (M). The membrane (52) has a weld seam (56). The actuator assembly (100) has a base member (102) configured to mount on the container (48). A fracturing mechanism (116) is operably connected to the base member (102). The fracturing mechanism (116) has a first extending member (132a) and a second extending member (132b), the first extending member (132a) and the second extending member (132b) positioned on the base member (102) in opposed relation. Each extending member (132a,132b) has a projection (150a,150b) positioned proximate the membrane (52). In response to deflection of the extending members (132a,132b) towards one another, the projections (150a,150b) are configured to deflect the outer wall (50) proximate the membrane (52) wherein the weld seam (56) fractures to create an opening through the membrane (56) to allow the flowable material (M) to pass therethrough.

A dispensing system provides for the delivery of a contained substance sealed in a Dispensable Containment Vessel (DCV) into a target container, which can contain another substance. The dispensing system includes a dispensing adaptor (Dispensing System) that couples the DCV to the target container so substances can be transferred between the containers without escaping or contacting the user. When the DCV is activated from a secure conformation into a dispensing conformation, the dispensing adaptor sealably engages the target container and portions of the dispensing adaptor place stress on a barrier, which frangibly tears along defined tearing paths to form vents or flaps that are forced apart against the dispensing adaptor, allowing the contents of the DCV to enter the target container. The dispensing conformation also facilitates the efficient mixture of substances and allows them to travel between the containers to flush residual DCV contents into the target container.

Various embodiments of the present disclosure provide a cartridge for dispensing two-part fluids. In one embodiment, the cartridge comprises a cartridge body having a dispensing end and defining a first fluid reservoir and a second fluid reservoir. The dispensing end defines at least one aperture fluidly connected to the first fluid reservoir. The dispensing end also defines a dispensing conduit fluidly connected to the second fluid reservoir. The cartridge further comprises a nozzle member engageable with the cartridge body to form an outlet and to fluidly connect the at least one aperture to the outlet.

The metering device includes a metering container which can be fitted with screwing action on a standard bottle neck. The metering container has a funnel-shaped base, which is adjoined by a cylindrical lateral wall having, at the upper end, a cross-sectionally u-shaped collar, to which a cover surface can be applied in a form-fitting manner. At the top of the metering device is a pressure-exerting head with an encircling, detachable periphery. A puncturing mechanism having a two-part pressure-exerting pin can be actuated by the pressure-exerting head. The puncturing mechanism is fixed to the cover surface, prior to initial use, and is separated out of the cover surface by a cylindrical casing wall on the pressure-exerting head. The second part of the puncturing mechanism has a punching sleeve, which severs membranes which close the metering container, whereupon the contents of the metering container can be supplied into the bottle.

The metering device includes a metering container which can be fitted with screwing action on a standard bottle neck. The metering container has a funnel-shaped base, which is adjoined by a cylindrical lateral wall having, at the upper end, a cross-sectionally u-shaped collar, to which a cover surface can be applied in a form-fitting manner. At the top of the metering device is a pressure-exerting head with an encircling, detachable periphery. A puncturing mechanism having a two-part pressure-exerting pin can be actuated by the pressure-exerting head. The puncturing mechanism is fixed to the cover surface, prior to initial use, and is separated out of the cover surface by a cylindrical casing wall on the pressure-exerting head. The second part of the puncturing mechanism has a punching sleeve, which severs membranes which close the metering container, whereupon the contents of the metering container can be supplied into the bottle.

A multi ply plastic film to create a heat-sealed enclosure for food to be heated inside the enclosure save for a region of the heat-seal where a vent-opening can be established to allow gas and/or steam to escape the enclosure during heating of the food. The film has a primary panel to create the enclosure by heat sealing to itself or a separate panel or to a peripheral lip of a container There is also provided a release panel applied to said primary panel to be located intermediate of and to prevent the primary panel being heat-sealed to itself or peripheral lip at the peripheral heat-sealed region for the vent-opening to thereat be established.