The disclosure is directed to a device and method of treating bone formation disorders or conditions by bioengineering a targeted bone tissue and modulating the homeostasis of osteogenesis and bone resorption by a localized delivery of peripheral blood mononuclear cells and/or hematopoietic stem cells, and/or cells, such as osteoclasts, obtained by the ex vivo differentiation of these cells. A therapeutic strategy, as well as a device to deliver the therapeutic strategy, is described herein.

A detachable orthodontic bracket and wire system includes bracket bases, brackets, and an arch wire for guiding alignment of teeth. The bracket bases are positioned on a lingual surface and/or a facial surface of the teeth. Each bracket base includes a first surface, a second surface, and at least one first interlocking element. The first surface is rigidly attached to the lingual surface and/or the facial surface of the teeth. The second surface opposes the lingual surface and/or the facial surface of the teeth. The first interlocking element is attached to and positioned in a direction substantially perpendicular to or parallel to the second surface of each bracket base. The brackets include at least second interlocking element that interlocks with the first interlocking element. The arch wire is inserted through a slot channel of each bracket. The bracket and the arch wire are infused and rigidly anchored within enclosing layers.

A detachable orthodontic bracket and wire system includes bracket bases, brackets, and an arch wire for guiding alignment of teeth. The bracket bases are positioned on a lingual surface and/or a facial surface of the teeth. Each bracket base includes a first surface, a second surface, and at least one first interlocking element. The first surface is rigidly attached to the lingual surface and/or the facial surface of the teeth. The second surface opposes the lingual surface and/or the facial surface of the teeth. The first interlocking element is attached to and positioned in a direction substantially perpendicular to or parallel to the second surface of each bracket base. The brackets include at least second interlocking element that interlocks with the first interlocking element. The arch wire is inserted through a slot channel of each bracket. The bracket and the arch wire are infused and rigidly anchored within enclosing layers.

An aesthetic, partially removable orthodontic appliance is described, including a polymeric body that conforms to the lingual soft tissue and at least one wire member extending from the polymeric body. Each wire member releasably engages with a respective anchor that is, in turn, connected to the lingual surface of a respective tooth when the polymeric body is moved in a generally gingival direction into abutting relationship with the lingual soft tissue. Other features of the appliance include self-guiding magnetic couplings and couplings based on interlocking mechanical structures that provide releasable engagement between the removable section and the anchors, as well as related methods for making and using the same.

An aesthetic, partially removable orthodontic appliance is described, including a polymeric body that conforms to the lingual soft tissue and at least one wire member extending from the polymeric body. Each wire member releasably engages with a respective anchor that is, in turn, connected to the lingual surface of a respective tooth when the polymeric body is moved in a generally gingival direction into abutting relationship with the lingual soft tissue. Other features of the appliance include self-guiding magnetic couplings and couplings based on interlocking mechanical structures that provide releasable engagement between the removable section and the anchors, as well as related methods for making and using the same.

Maxillary protraction device comprising a cranial support (1) that may be attached with straps (4) or similar on the forehead of the user. A guide (8) in a central position on the support (1) attaches to the upper end (9) of a vertical rod (2), at the lower end (13) of which a horizontal rod (3) is arranged with gripping points for the rubber bands that provide a tractive force on the jaw to be treated. Between the two ends (9, 13) of the rod, a ratchet mechanism (12) or similar may be arranged to adjust the angle, while the lower end (13) can be telescopic.

Maxillary protraction device comprising a cranial support (1) that may be attached with straps (4) or similar on the forehead of the user. A guide (8) in a central position on the support (1) attaches to the upper end (9) of a vertical rod (2), at the lower end (13) of which a horizontal rod (3) is arranged with gripping points for the rubber bands that provide a tractive force on the jaw to be treated. Between the two ends (9, 13) of the rod, a ratchet mechanism (12) or similar may be arranged to adjust the angle, while the lower end (13) can be telescopic.

An orthodontic/orthognathic device for correcting and changing tooth placements and bone structure, and a method of using orthodontic/orthognathic device for tooth movement, correcting syndromic conditions of the mouth and osteogenetic correction. The device may be used for maxillary distraction and expansion as well as mandibular separation and expansion. The device can be controlled by computer to direct tooth and bone placement.

An orthodontic/orthognathic device for correcting and changing tooth placements and bone structure, and a method of using orthodontic/orthognathic device for tooth movement, correcting syndromic conditions of the mouth and osteogenetic correction. The device may be used for maxillary distraction and expansion as well as mandibular separation and expansion. The device can be controlled by computer to direct tooth and bone placement.

A maxilla holder includes a base plate and a connecting member. One end of the connecting member is connected with the base plate which extends along a pre-designed occlusal plane while the other end of the connecting member includes at least two supporting portions. With the supporting portions abutting against the cranium, the base plate is positioned so that the maxilla is located in a pre-planned position once it is moved onto the base plate.