A waste disposal system with a waste receiver for receiving pharmaceutical waste material. A locking assembly is secured to a fixed surface and actuated from a locked configuration to an unlocked configuration. A lock cylinder of the locking assembly may extend forward of a front wall of a receiver body of the waste receiver to engage a locking feature of the cover in the locked configuration. A cover retention feature may prevent axial decoupling of the cover from the receiver body. The receiver body may be formed from two shells. A reaction agent is positioned within the container volume and spaced apart from a bottom wall of the receiver body. The reaction agent may be positioned within the container volume between the lock passageway and/or a solid receiver volume, and opposing sidewalls of the receiver body. A support may maintain the position of the reaction agent within the container volume.

A waste disposal system for receiving pharmaceutical waste material including at least one of a solid phase pharmaceutical waste material and a liquid phase pharmaceutical waste material is provided. The waste receiver includes a receiver body defining an opening. The waster receiver further includes an inner surface defining a container volume in fluid communication with the opening, and an outer surface opposite the inner surface. The outer surface defines a lock passageway separate from the opening. The system further includes a bracket adapted to be secured to a fixed surface and a locking assembly coupled to the bracket and adapted to releasably secure the waste receiver to the fixed surface. The locking assembly includes a lock housing sized to be removably positioned at least partially within the lock passageway.