Methods and systems of promoting fertilization of eggs of an avian. While inseminating a plurality of avian eggs a spectrum substantially concentrated within a narrow range of wavelength irradiates the plurality of inseminated avian eggs to increase the motility of the sperm to increase the probability of conception of avian from the inseminated eggs.

The invention relates to methods of increasing the genetic progress of a line, breed or herd of swine through the use of sex-selected sperm cells in artificial insemination techniques. The invention also encompasses methods of artificially inseminating a swine via deep intrauterine catheter or via a laparoscopic procedure, which allow the use of reduced doses of sex-selected sperm cells.

Artificial vaginas are disclosed that include an elongate housing that may be cylindrical, a liner within the elongate housing that is attached to the elongate housing, a volume of pressurized warm air between the elongate housing and the liner, a pressure relief valve, an aperture centrally located within the elongate housing and the liner and an elongate body. The elongate body may contain a heating element, may be arranged to substantially fill the aperture and may be positioned within the aperture to prepare the artificial vagina for use.

Methods and compositions directed to altering a population of sRNAs in a sperm using vesicles isolated from an epididymosome are provided. Methods and compositions directed to altering a population of sRNAs in an oocyte using vesicles isolated from an epididymosome are also provided. Methods for altering an sRNA population in a sperm or an oocyte can be used to prevent, or reduce the severity of, a disease, disorder, or condition that would otherwise be inherited by progeny. For example, certain epigenetic inherited conditions due to paternal effects, such as certain metabolic and stress disorders and conditions, can be ameliorated in progeny using sperm or oocytes having an altered sRNA population.

Methods and compositions directed to altering a population of sRNAs in a sperm using vesicles isolated from an epididymosome are provided. Methods and compositions directed to altering a population of sRNAs in an oocyte using vesicles isolated from an epididymosome are also provided. Methods for altering an sRNA population in a sperm or an oocyte can be used to prevent, or reduce the severity of, a disease, disorder, or condition that would otherwise be inherited by progeny. For example, certain epigenetic inherited conditions due to paternal effects, such as certain metabolic and stress disorders and conditions, can be ameliorated in progeny using sperm or oocytes having an altered sRNA population.

Novel benzamide derivatives of formula (I)

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wherein W.sup.1, W.sup.2, R.sup.1 to R.sup.10 and X have the meaning according to the claims, are positive allosteric modulators of the FSH receptor, and can be employed, inter alia, for the treatment of fertility disorders.

The invention relates to an appliance for vaginal penetration, comprising a grip (2), said appliance being designed to receive a working tool, especially an insemination gun (4) that passes through the grip, characterised in that it comprises a guiding tube (8) extending the grip (2) in order to form a compact assembly, said guiding tube being designed so as to receive the front tip of the working tool (12) therein and receiving a video viewing means such as an endoscopy-type tube (14) comprising a lighting element on the front end thereof, the appliance for vaginal penetration comprising an electronic cell receiving the video images, provided with means for transmitting images to a remote screen.

A method of artificially inseminating a hen includes the steps of securing a male bird, applying a semen extender liquid to a tip of a cloacal protuberance of the male bird, squeezing the cloacal protuberance to extract semen from the male bird into the semen extender liquid to form a mixture, applying a tip of a pipette to the mixture, drawing the mixture into the pipette, securing the hen, inserting the pipette into the hen's cloaca, and squeezing a bulb of the pipette to inject the mixture from the pipette into the cloaca. A holding device for restraining a bird during sperm collection and artificial insemination procedures has a base, an arm extending upward from the base, and an open-ended receptacle connected to the upper end of the arm. The holding device is useful in mitigating injury to the bird and the handler during the procedures.

The present invention provides an artificial insemination apparatus and methods for use with livestock that maintains the sterility of the semen until it is deposited at an optimum location in the reproductive tract of the animal without the maneuvering or tissue injury problems associated with prior art devices. Embodiments of the present invention comprise a uniquely shaped opening that is provided at the tip of a sheath that is used with an artificial insemination gun, and a movable or deformable plug or diaphragm that fits into and covers this opening. The plug or diaphragm has a rounded (convex) exterior surface, and may be made of a rigid or rubberized material that completely covers the opening at the tip of the sheath, and seals it closed in a smooth, flush engagement to prevent contaminants from collecting upon the tip, or entering into the sheath during the trip through the reproductive tract of the animal. Once the sheath is properly placed in the reproductive tract, application of fluid pressure to the semen inside the sheath causes the plug to move or deform without becoming detached from the sheath, thereby allowing semen inside the sheath to exit. In alternative embodiments, the unique tip with its opening and corresponding plug may be provided in a separate cap that is installed at the end of an insemination sheath.

Methods and compositions for synchronizing the time of insemination in swine are described. More particularly, methods are described for synchronizing the time of insemination by administration of a composition comprising a hormone, wherein the swine is inseminated only one time after administration of the hormone, and wherein there is no heat detection.