A mesh implant is disclosed and comprises a single sheet, highly porous, adhesion-resistant, tensile surgical implant composed of a gradually biodegradable synthetic polymer material that is electrospun into nanofibers and randomly stacked to form a three-dimensional (3D) mesh. The mesh implant is for tissue repair and hernia repair. The single-sheet design reduces the foreign material that make up the mesh implant, which minimizes mesh implant rejection. The gradually biodegradable nature of the mesh implant guarantees that the mesh stays in place and supports the repaired site long enough until a proper scar tissue has built up, after which the mesh implant disappears from the body, therefore preventing pain and irritability. The 3D design of the nanofibrous network and the high porosity of the mesh implant facilitate cell attachment, infiltration, and proliferation, all necessary for scar tissue formation, mesh integration, wound healing, and proper defect closure.

There is disclosed an acellular dermal matrix (ADM) graft stored as a packaged ADM graft pocket product prepared by a process that includes providing a portion of ADM tissue having a thickness between 1 mm and 2 mm. The process includes scoring the portion of the ADM tissue into a pre-defined shape to form the domed shape ADM graft. The process includes verifying the thickness of the domed shape ADM graft; shaping the domed shape ADM graft to form an ADM graft pocket configured to receive a breast implant. The process includes packaging the ADM graft pocket to form a packaged ADM graft pocket. The process includes irradiating the packaged ADM graft pocket to a sterility assurance level of a desired level to form the packaged ADM graft pocket product. Other embodiments are also disclosed.

A size adjustable cover used for soft tissue reinforcement which is adapted to envelop an implantable device, such as a breast implant, in a surgical application. The cover is formed using a circular two-dimensional implantable matrix material having an inner circle and a plurality of fringes which radiate circumferentially from the inner circle. The implantable device is positioned upon the inner circle, and the plurality of fringes are folded inwardly to form an overlapping implant pocket which envelops the implantable device. Each fringe further has a punched opening, allowing a loop of suture thread to link each fringe together. Certain fringes are excluded from the loop to create stabilization tabs which radiate from the inner circle and are attached to a site of host implantation to stabilize the cover and the implantable device within.

Provided are intraoperative devices, the devices comprising a substrate having a plurality of discontinuous cuts formed therein, the plurality of discontinuous cuts being formed such that when the substrate is subjected to deformation, the substrate is capable of deformation beyond an initial state so as to achieve a first shaped three-dimensional state. Through design of the cut patterns in 2D, one can locally control the stretchability and elasticity within the substrate. The substrate can then be deformed into a 3D structure that can provide shape and support to reconstructed tissue in the desired regions while also minimizing operative time and cost. Also provided are related methods of using the disclosed devices; the devices can be used in autologous tissue donation procedures as well as prosthetic procedures.

Soft tissue repair grafts are provided for supporting, covering, and/or retaining an implant positioned in the body of a subject. The grafts are particularly suitable for use for pre-pectoral breast reconstruction with a breast implant or tissue expander. The grafts include positional notches for more accurate positioning in a subject. The grafts also include at least one cuff element which is folded to form a reinforced folded edge for suturing the graft more securely to adjacent tissues than previously known grafts. The grafts also include a plurality of arcuate slots which form a plurality of circular patterns arranged concentrically about a focal point, thereby enabling the grafts to expand without tearing and to conform more closely to the implant and/or adjacent body tissues such as the breast pocket, than previously known grafts. Acellular dermal matrices are particularly suitable for making the soft tissue repair grafts.

A reinforcement device for reinforcing tissues having one or more structural deficiencies includes a longitudinally-extending reinforcing layer for treating the structural deficiency, a plurality of spiked naps distributed across the reinforcing layer and projecting therefrom for adhering to the tissue, and a dissolvable matrix layer covering at least a portion of the reinforcing layer and a portion of the plurality of spiked naps. The matrix layer increases the time before the spiked naps substantially adhere to the tissue, thereby allowing the practitioner additional time to position the reinforcement device.

The system and method for laparoscopic repair of abdominal wall hernia using umbrella mesh includes an umbrella mesh having a substantially circular mesh attached to an umbrella-like frame having a plurality of radially spaced spokes resiliently mounted at a hub, the spokes being hollow and housing helical tacks. The umbrella mesh is folded and mounted on an umbrella load cartridge. The cartridge may be loaded on the distal end of a pistol-grip laparoscopic instrument having a rotary control for orienting the mesh over the weakened area, a mesh release handle for gradually opening and releasing the mesh, and a firing handle for firing helical tacks from the spokes for fastening the mesh to the supporting abdominal wall.

An applicator instrument for dispensing surgical fasteners includes a housing, a firing system moveable along a first axis, a handle extending upwardly from the housing along a second axis that defines an acute angle with the first axis, the handle having an upper free end that defines a top of the applicator instrument, a trigger coupled with the housing for activating the firing system, and an elongated shaft extending from the distal end of the housing, the elongated shaft having a proximal shaft section extending along the first axis and a distal shaft section that is oriented at an angle relative to the proximal shaft section for extending upwardly toward the top of the applicator instrument. The trigger is squeezed for dispensing surgical fasteners from the distal end of the elongated shaft. The applicator instrument has at least one visual indicator for indicating a proper orientation for the applicator instrument in which the upper free end of the handle is positioned above the housing.

Compositions-of-matter comprising a matrix made of one or more, preferably two or more elastic layers and one or more viscoelastic layer are disclosed. The compositions-of-matter are characterized by high water-impermeability and optionally by self-recovery. Processes of preparing the compositions-of-matter and uses thereof as tissue substitutes or for repairing damaged tissues are also disclosed.

One aspect of the present disclosure relates to a tissue repair implant comprising a first layer of extracellular matrix and a second support layer of biocompatible material securely attached to the first layer at one or more fixation points. At least one of the fixation points comprises a first projection that is associated with the first layer and securely attached, via a fixation mechanism, to the second support layer.