Compositions and methods for inhibiting and interrupting biofilm formation, and for destabilizing established biofilms are provided, the novel compositions including polymeric resins and monomeric non-polymerizable and polymerizable resins. More particularly, the compositions and methods enable the protection and removal of biofilms from surfaces in the context of medical, consumer, domestic, food service, environmental and industrial applications, where the effects constitute beneficial and desirable biofilm attenuating activity.

A sleeve for soft tissue repair includes a cylindrical tube formed of at least one biocompatible material, and a suture tethered to one end of the cylindrical tube. The cylindrical tube is configured to be fitted over a soft tissue. The cylindrical tube is configured to reversibly and repeatedly deform from a relaxed state to a stretched state in which the cylindrical tube contracts in a radial direction and expands in a longitudinal direction to secure the soft tissue within the cylindrical tube.

An improved abdominal hernia repair system is presented comprised of a silicone layer backed up with a knitted or woven polypropylene fabric layer, the silicone layer possessing a regular pattern of slits that permit equilibration of fluid pressure across the device. A variety of therapeutic substances can be applied to the hernia repair device to promote healing, including aloe and other medicinal preparations. A layer of water soluble or water insoluble anti-scar compound is also present, the preferred compound being Salinomycin.

An improved inguinal hernia repair system is presented that is identical to the above except it does not contain the hydrophobic silicone component.

Embodiments disclosed herein relate to prosthetics for augmenting or repairing a tissue defect, such as a ventral or incisional hernia. In some embodiments, a repair prosthetic may include a patch body and a first fastener attached to a first portion of the patch body. A coupler may be attached to and extend from a second portion of the patch body, and a second fastener may be attached to the second portion of the patch body via the coupler. The coupler may be retracted relative to the second portion of the patch body or the second fastener to apply tension to the patch body in some embodiments.

A method of preventing or reducing the occurrence and/or development of a hernia within a subject at risk of developing a hernia includes implanting a graft material in contact with an opening in an abdominal wall. The graft material promotes healing of the abdominal wall and includes placental or placental derived tissue.

The present disclosure provides filaments and/or surgical sutures which include an inner core, an outer sheath and a plurality of barbs on a surface thereof. The filaments and/or surgical sutures further include at least one adhesive precursor material which transitions from a non-adherent material to an adhesive material to attach a portion of the filament and/or suture to the surrounding area, such as tissue and/or other portions of the filament.

An assembly for the repair of a hernia. The assembly includes an elongated shaft having a first end; a first holding member at least mostly positionable in the elongated shaft and a second holding member positionable in the elongated shaft; a coupler assembly having (i) a coupler for coupling the first holding member to the second holding member and (ii) a locking arrangement; a deployment assembly for deploying at least one of the first and second holding members out of the elongated shaft; a restrainer for restraining a portion of the coupler prior to the deployment of the second holding member out of the first end of the elongated shaft; wherein the coupler can be tensioned so as to pull the first holding member and the second holding member towards each other and the locking arrangement is lockable about the coupler. Methods of repairing a hernia by closing a hole in the fascial layer of an abdominal wall are also disclosed.

A method of generating a computer-based observable model of an implantable repair material secured to a patient is provided. The method includes processing data corresponding to a patient using a computing device including a processor and a memory storing a software application executable by the processor. The method also includes indicating an implantable repair material and a fixation for securing the implantable repair material to the patient and indicating a distribution of the fixation about the implantable repair material. The method also includes generating an observable model of the implantable repair material secured to the patient on a display operably associated with the computing device. The observable model depicts the indicated distribution of the fixation about the implantable repair material.

An auto-graft bio-synthetic mesh and a method of application for wound closure is described. The mesh is utilized for wound closure wherein an abdominal incision is effected through the peritoneum and the rectus abdominal sheath of the rectus muscle such as when repairing ventral or paracoslostomy hernias. The mesh comprises a flexible patch of woven fibers and wherein the patch is one of a substantially circular patch or a patch having a substantially circular delineation thereon whereby to provide guidance for the formation of stitches in at least one circle to secure the patch to the peritoneal peritoneum and the rectus abdominal sheath of the rectus muscle. The patch is secured by applying stitches all about an outer circular edge of the patch and an inner circle thereof. A suture clip for joining portions of bodily soft tissue is also described.

A method is provided for maintaining the position of pelvic organs, such as components of the urinary tract. The method may involve anchoring the pelvic organs by inserting the implant via an anterior approach, avoiding complications and side effects that result when implants are inserted through the wall of the vagina.