A method is described of improving adhesion of an ocular implant to corneal tissue by forming an implant adhesive layer on the ocular implant, the implant adhesive layer having greater adhesive strength than a rest of the implant or by forming a corneal adhesive layer on a posterior surface of a posterior portion of the corneal tissue, the corneal adhesive layer having greater adhesive strength than a rest of the corneal tissue.

Scaffolding constructs, medical devices comprising scaffolding constructs, and related methods of manufacturing and treatment are described. The scaffolding construct may comprise a biocompatible material, such as a polymer, copolymer, or hydrogel. The scaffolding construct may be porous and at least partially bioresorbable. Further, for example, the scaffolding construct may define a cavity for securing a medical implant therein.

Apparatus and methods are described for treating a subject with a diseased atrioventricular valve. A docking element is implanted within the subject's atrium such that no portion of the docking element extends through the subject's atrioventricular valve. The docking becomes anchored to tissue of the atrium at least partially via ingrowth of the tissue of the atrium. The docking element includes a ring, which is implanted at the annulus of the atrioventricular valve, and a frame having a height of at least 15 mm, which extends upwardly from the ring. A prosthetic atrioventricular valve apparatus is placed at least partially inside the docking element subsequent to the ingrowth of the tissue of the atrium having occurred, and becomes anchored to the docking element, at least partially by radially expanding against the ring. Other applications are also described.

A stent comprises an elastically deformable stent wall forming a lumen extending between a first opening and a second opening of the stent. The stent wall is configured to be percutaneously delivered into a blood vessel, secure to a blood vessel wall of a blood vessel, and radially expand from a first configuration to a second configuration within the blood vessel into direct contact with the blood vessel wall. The first configuration defines a first major dimension, a first minor dimension, a first cross-sectional area, a first cross-sectional shape, and a first perimeter of the stent wall. The second configuration defines a second major dimension, a second minor dimension that is greater than the first minor dimension, a second cross-sectional area that is greater than the first cross-sectional area, and the first perimeter of the stent wall.

A tube stent includes a first tube body. The first tube body includes a first section, a second section, and a transition section located between the first section and the second section. One end of the transition section is connected to the first section, and the other end is connected to the second section. The shortening rate of the first section and the shortening rate of the second section are smaller than the shortening rate of the transition section. By using the tube stent, the pulsations of aortas are buffered by the transition section, so that vibration deformations of the tube stent are confined to the first section and the transition section, and accordingly the relative stability of the second section and branch blood vessels can be ensured, and the stimulations to walls of the branch blood vessels can be reduced.

A device having a structured coating for adhering to rough, in particular biological, surfaces, includes a carrier layer, wherein a plurality of protrusions is arranged on the carrier layer, which protrusions each comprise at least a shaft having an end face pointing away from the surface, and wherein a further layer is arranged at least on the end face, wherein the layer has a different modulus of elasticity than the protrusion in question. The further layer can also fill the intermediate spaces between the protrusions such that an internal structured coating is produced.

A kink resistant stent graft includes a graft forming a tube with a central lumen extending from a first end of the tube to a second end of the tube and a stent secured to the graft adjacent the first end of the tube. The graft includes a corrugated inner graft layer forming at least a middle portion of the tube, and an outer graft layer covering the corrugated inner graft layer.

Devices, methods and kits are described for reducing intraocular pressure. The devices include a support that is implantable within Schlemm's canal and that may restore or maintain at least partial patency of the canal without substantially interfering with transmural or transluminal fluid flow across the canal. The devices utilize the natural drainage process of the eye and may be implanted with minimal trauma to the eye. Kits may include a support and an introducer for implanting the support within Schlemm's canal. Methods may include implanting a support within Schlemm's canal, where the support is capable of restoring or maintaining at least partial patency of the canal without substantial interference with transmural or transluminal fluid flow across the canal.

A surgical implant having a surface treatment which contains primary cavities and secondary cavities. The primary cavities are larger than the secondary cavities and the primary cavities have an average length ranging from 20-500 micrometers. The surface treatment includes recasted material adjacent to a plurality of the primary cavities.

The present disclosure pertains to membranous tissue grafts comprising one or more pre-made attachment points. The one or more pre-made attachment points may include pre-made markings and/or pre-made suture holes. The membranous tissue grafts can be in the form of a tube. The membranous tissue grafts can also be rectangular in shape and can be used in a nerve repair by wrapping the severed or damaged nerve. In some embodiments, the membranous tissue grafts are suitable for repairing severed nerves that have a short gap or no gap with a gap of less than 5 mm between the severed stumps. Accordingly, methods are provided for repairing a damaged or severed nerve by implanting the membranous tissue grafts on to the damaged or severed nerve.