A method for preparing a biological material for implanting provides irradiating at least a portion of the surface of the material with an accelerated Neutral Beam.

A T-shaped anchorable mesh having a reticular structure with an intertwining mesh material, forming a tissue contact surface. The T-shaped anchorable mesh includes a long arm and a fixation part. The long arm has two lateral ends spaced from each other in an X direction and two marginal edges extending between the two lateral ends. The fixation part extends from one of the two marginal edges in a Y direction. The fixation part includes a plurality of protrusions emerging from the tissue contact surface.

An arthroscopic system for the repair of a ruptured anterior cruciate is provided. Aspects of the invention include a scaffold attached by a suture to an fixation device and inserted into a repair site via arthroscopic equipment. The scaffold and suture are further secured near or at the repair site via arthroscopic equipment having an elongated delivery member that contains the scaffold and suture prior to inserting the scaffold and suture into the repair site.

A compliant scaffold incorporates a plurality of elongated apertures that form a geometric pattern enabling biaxial expansion or contraction. An elongated aperture has a pair of nodes located on opposing sides of the aperture and between a pair of antinodes located on the extended and opposing ends of the elongated aperture. A geometric pattern may have various geometric shapes, or tiles, between the plurality of apertures. The geometric tiles have a bounded perimeter formed by the plurality of elongated apertures. A substantial portion of the elongated apertures may be configured with the antinodes proximal to one of said pair of nodes of a separate elongated aperture; wherein the antinodes are closer to one of the pair of nodes than to any other antinode. This unique arrangement of the elongated apertures may be formed in biological material in vivo or ex vivo.

Porous implantable devices for housing one or more therapeutic agents are disclosed herein. The implantable devices include a porous outer wall defining an interia or void. The interior void houses a carrier material carrying a first therapeutic agent. The implantable devices are made by patterning at least a portion of a polymerizable substrate into a polymerized three-dimensional porous outer wall surrounding an interior void. This can be achieved by two-photon polymerization techniques. A first therapeutic agent is then added to the interior void, which is then sealed. Methods of treating diseases using the implantable devices are disclosed herein. The methods include implanting the implantable device at a target area and locally releasing a therapeutically effective dosage of a first therapeutic agent from the interior void. The implantable devices can also be used in methods of screening potentially therapeutic agents for desired biological responses.

Embodiments herein relate to an implant for insertion into a patient. The implant comprises a plurality of unit cells arranged to form a three-dimensional lattice structure, the three-dimensional structure comprising a resting volume of the implant. The plurality of unit cells are arranged to form a porous network of the three-dimensional structure, and wherein the three-dimensional structure is a reversibly compressible three-dimensional structure, wherein a bulk porosity of the three-dimensional structure of the implant is at least 50%. Also disclosed is a method of tissue reconstruction or tissue augmentation. The method comprises implanting into the body of a subject an implant of the disclosure.

A cortical shaft bone fixation apparatus includes a housing having a leading portion and a trailing portion, the leading portion configured to fit within a diameter of an affected cortical shaft bone, the leading portion having first and second sections. The apparatus further includes an expansion mechanism adapted to transition the first and second sections from a first position to a second position, the first and second sections providing an outward force against the inside surface of the cortical shaft bone when the first and second sections transition from the first position to the second position, the trailing portion of the housing abutting a leading end of the affected cortical shaft bone. The trailing portion of the housing includes a pair of angled tapers extending inwardly toward each other to a minimum separation distance at an extreme end of the housing.

A device having a structured coating for adhering to rough, in particular, biological surfaces, includes a carrier layer, wherein a plurality of protrusions is arranged on the carrier layer, which protrusions each comprise at least one stem having an end face pointing away from the surface, and wherein a further layer is arranged at least on the end face, wherein the layer has a lower modulus of elasticity and is in the form of a film that interconnects the protrusions. The film can also be in the form of a removable film.

A system of prosthetic implants for a total knee replacement procedure is provided. The system includes a tibial component of a knee joint implant, a tibial insert configured to be positioned against the superior side of the platform of the tibial component, a first femoral component of a knee joint implant, and a second femoral component of a knee joint implant.

The invention relates to an endoprosthesis (1), in particular a vascular stent or a heart stent, comprising at least one body (3) part. At least one area (5,6) of an outer surface, preferably the whole outer surface, of the at least one body part (3) is provided with thrombogenic fibers (2). The invention further relates to methods of manufacturing endoprostheses (1).