A biocompatible membrane composite including a cell impermeable layer and a mitigation layer is provided. The cell impermeable layer is impervious to vascular ingrowth and prevents cellular contact from the host. Additionally, the mitigation layer includes solid features. In at least one embodiment, mitigation layer has therein bonded solid features. In some embodiments, the cell impermeable layer and the mitigation layer are intimately bonded or otherwise connected to each other to form a composite layer having a tight/open structure. A reinforcing component may optionally be positioned external to or within the biocompatible membrane composite to provide support to and prevent distortion. The biocompatible membrane composite may be used in or to form a device for encapsulating biological entities, including, but not limited to, pancreatic lineage type cells such as pancreatic progenitors.

The present invention relates to a patient-specific breast implant. More particularly, the present invention relates to a patient-specific breast implant which, when a breast-conserving surgery (BCS, also called lumpectomy or partial mastectomy) is performed to remove breast cancer while leaving as much normal breast tissue as possible, prevents deformation of breast that may occur due to the depression of breast skin or adhesions of remaining breast tissues after the BCS, shortens surgery time, and facilitates securing breast symmetry, thereby ultimately dramatically increasing the success rate of surgery and maximizing patient satisfaction.

Methods of producing hybrid fibrous scaffolds are provided. The methods include dissolving a polymer, such as polydioxanone, in a solution, such as 1,1,1,3,3,3-hexafluoro-2-propanol (HFP), to form a polymer-containing solution. The method comprises electrically charging the polymer-containing solution. The method comprises writing the polymer-containing solution on a counter electrode or a ground in a grid pattern to form semi-stable fibers comprised of the polymer, the semi-stable fibers vary between bent and straight and forming the hybrid fibrous scaffold. The writing may be performed by a 3D printer. The resulting scaffolds and methods of using the same are also disclosed herein.

A tubular prosthesis that includes a scaffolding formed by at least one scaffolding filament; a cover; and at least one controlled ingrowth feature constructed and arranged to abut an inner surface of a lumen wall when the prosthesis is implanted in the body lumen. The controlled ingrowth feature may extend inwards or outwards from the prosthesis outer surface. The controlled ingrowth feature may be formed by a scaffolding filament; by a separate filament; by the cover; and combinations thereof.

The invention is an improved biocompatible surface for a variety of medical purposes. The biocompatible surface employs a unique tight microstructure that demonstrates enhanced cellular response in the body, particularly when placed in contact with blood. As a blood contact surface, the present invention can be beneficially employed in a wide variety of implantable devices and in many other devices and equipment that come in contact with blood.

A receiver assembly for securing an elongate rod to a bone anchor includes a receiver having a channel configured to receive the elongate rod and a helically wound receiver guide and advancement structure formed into interior surfaces of the receiver. The receiver assembly further includes a threaded plug configured for positioning within the channel to secure the elongate rod to the receiver in a locked configuration, with the threaded plug having a lower axially protruding portion configured to compress the rod so as to prevent rotational and axial movement between the rod and the receiver in the locked configuration.

An implantable prosthesis valve device and a method for implanting the same are provided. The device includes a frame body. The frame body includes a valve leaflet fixing portion for fixing prosthetic valve leaflets, and a first fixing portion located at one end portion of a frame. In an axial direction, the frame body further includes a first buffer portion located between the first fixing portion and the valve leaflet fixing portion, and a second buffer portion located between the other end portion of the frame body and the valve leaflet fixing portion, wherein at least one of the first buffer portion and the second buffer portion has an elasticity in the axial direction.

A device having a structured coating for adhering to rough, in particular biological, surfaces, includes a carrier layer, wherein a plurality of protrusions is arranged on the carrier layer, which protrusions each comprise at least a shaft having an end face pointing away from the surface, and wherein a further layer is arranged at least on the end face, wherein the layer has a different modulus of elasticity than the protrusion in question. The further layer can also fill the intermediate spaces between the protrusions such that an internal structured coating is produced.

Methods of delivering a prosthetic aortic heart valve are disclosed. The disclosed methods include loading a prosthetic aortic valve in a collapsed configuration into a delivery sheath so that a selected point on the prosthetic valve is rotationally aligned relative to a long axis of the delivery sheath with a selected radiopaque marker on the delivery sheath, while under fluoroscopic imaging, rotating the delivery sheath about its long axis to align a selected radiopaque marker on the delivery sheath with the selected point on the native aortic valve in a fluoroscopic imaging plane, thereby establishing a desired orientation of the prosthetic aortic valve with respect to the native aortic valve in which the prosthetic valve commissures are rotationally aligned with commissures of the native aortic valve, further advancing the delivery sheath along its long axis until the prosthetic aortic valve is disposed inside the native aortic valve, and deploying the prosthetic aortic valve into an implanted state inside the native aortic valve with the prosthetic aortic valve aligned in the desired orientation with respect to the native aortic valve.

Described are medical devices including expandable tubular bodies configured to be implanted into a lumen, wherein the outer surface of the expandable tubular bodies are coupled to a polymer(s).