Improved breast prostheses, methods of making breast prostheses, and methods of treatment using such breast prostheses are described.

The invention relates to an endoprosthesis (60), in particular a vascular stent or a heart stent, comprising a graft (2) with a graft surface (3). The endoprosthesis (60) further comprises at least one fiber (1) which is arranged on the graft surface (3). The graft surface is adapted to directly attach the fiber (1).

Certain aspects of the present disclosure provide a flexible scaffold implant comprising a plurality of layered structures, the plurality of layered structures comprising: a first layered structure having a three-dimensional (3D) shape and formed from a bioresorbable material, and a second layered structure conforming to the corresponding 3D shape of the first layered structure and formed from the bioresorbable material. The first layered structure is arranged in proximity to the second layered structure. The first layered structure is configured to dissolve for resorption at a different rate than the second layered structure based on design elements of the first layered structure and the second layered structure. The plurality of layered structures are flexible.

Intrasaccular devices and methods of implanting the devices in an aneurysm are described. The device includes an expandable body comprising a plurality of elongate filamentary elements each having a first and a second end. Each of the plurality of elongate filamentary elements extends from a first end of the device to a second end of the device and back to the first end of the device. The first and second ends of each of the plurality of elongate members are coupled at the first end of the device in a hub. The device may further include a defect spanning structure made of a mesh. The defect spanning structure may be located around a proximal portion of the expandable body, and may be disposed exteriorly to an outer surface of the expandable body

A tissue graft product comprising two or more layers of material wherein each layer comprises extracellular matrix (ECM) or polymeric material and wherein the layers are laminated together by interlocking portions of one layer with portions of another layer.

An implantable prosthesis for mending anatomical defects, including a groin hernia. The prosthesis includes a prosthetic repair patch that may be implanted in different tissue planes to mend a defect. The patch may include a medial portion configured to be positioned in a first tissue plane and a lateral portion configured to be positioned in a second tissue plane offset from the first tissue plane. The patch may include a transition region configured to extend through tissue and/or muscle, such as fascia, separating the tissue planes and transition the patch from one tissue plane to the other tissue plane. The transition region may be configured to inhibit buckling and/or bunching of the patch when implanted through the fascia. The lateral portion of the patch may have a level of stiffness that facilitates implantation of the patch in different tissue planes while inhibiting patient sensation to the implanted patch.

A delivery device (1) for an endoprosthesis (2). The endoprosthesis (2) is preferably an endoprosthesis for treating an aneurysm. The delivery device (1) comprises an outer sheath (3) and an inner tube (4). The inner tube (4) is arranged within the outer sheath (3) and at least one restraining tube (5, 30). The restraining tube (5, 30) is for holding the endoprosthesis (2) in a compressed configuration. The restraining tube (5, 30) is arranged between the outer sheath (3) and the inner tube (4). The outer sheath (3), the inner tube (4) and at least one restraining tube (5, 30) are coaxial. The restraining tube (5, 30) includes at least one axial elongation (6) extending from a distal end portion of the restraining tube. The at least one axial elongation (6) is adapted to be laced through portions of the endoprosthesis (2).

A prosthetic device for sealing a native heart valves to prevent or reduce regurgitation comprises a spacer having one or more anchors. The spacer may also have atrial support structures, ventricular support structures, or both atrial and ventricular support structures In some cases, the spacer has anchors that attach to the leaflets as well as atrial and ventricular support. In some cases, the spacer straddles the annulus and is located by anchors, and in some cases the support structures can be implanted within the native heart valve. In some cases, the prosthetic device reduces the annulus diameter when implanted within the native heart vasculature. In some cases, the prosthetic device cinches the annulus when implanted within the native heart vasculature.

Luminal grafts and methods of making and using the same. An exemplary luminal graft of the present disclosure is configured as a generally tubular element configured for nerve cells to grow therethrough and comprises at least one sheet of biological tissue having elastin fibers and collagen fibers, with the elastin fibers being a dominant component thereof; and a plurality of microchannels formed on a surface of the at least one sheet of biological tissue, each of the microchannels extending longitudinally between a first end and a second end of the at least one sheet of biological tissue and configured to provide intraluminal structural guidance to nerve cells proliferating therethrough.

The invention relates to a mesh support device (10; 20) for supporting a breast implant (30), wherein the mesh support device (10; 20) is tubular and comprises a first circumferential mesh area (11; 21), which is characterized by a first set of mesh characteristics and which has a first circumferential length, and a second circumferential mesh area (12; 22), which is characterized by a second set of mesh characteristics and which has a second circumferential length, the first set of mesh characteristics being different from the second set of mesh characteristics. The invention relates also to a breast implant device comprising the breast implant (30) and the mesh support device (10; 20).