An improved holder and storage system for prosthetic heart valves that pre-shields or pre-constricts the commissure posts of the valve to prevent suture looping. Pre-shielding and pre-constriction mean at the time of manufacture, so that the valves are stored with the commissure posts shielded and/or constricted. The holders may have solid legs that directly contact and constrict and hold the commissure posts without the use of sutures in tension that might creep over the time in storage. The holder may have a base in contact with the inflow end and a shaft portion that projects through the valve leaflets and cooperates with movable legs on the outflow end of the valve in contact with the commissure posts. The holders may, alternatively, have flexible leg members that extend through the valve and have distal end portions configured to extend over and shield the tips of commissure posts.

A heart valve assembly for endovascular heart repair, where the valve is in an inverted position relative to the stent to reduce the diameter of the device for delivery and deployment. The heart valve assembly has an expandable stent and a valve. The valve having a proximal end and a distal end, the proximal end of the valve connected to the distal end of the expandable stent, wherein the valve extends distally from the distal end of the expandable stent.

A packaging system includes a holder and an inner container. The holder includes a top portion and a bottom portion that cooperate to form a cavity configured to receive one or more medical products therein and to retain the one or more medical products therein. The inner container defines an interior region configured to receive the holder therein. The holder includes sidewalls that form the cavity, and the sidewalls include channels configured to fluidly connect the cavity to the interior region of the inner container.

A silicone prosthesis delivery apparatus and associated methods are disclosed for facilitating the transport and subsequent insertion of a silicone prosthesis into a surgically developed pocket of a patient. In at least one embodiment, a flexible, substantially funnel-shaped delivery sleeve is configured for receiving and subsequently expelling the prosthesis therefrom. The delivery sleeve provides a substantially conical-shaped entry portion and a substantially conical-shaped exit portion, the entry portion and exit portion opposingly positioned and joined with one another so as to form a relatively larger diameter middle section. A tapered free end of the entry portion provides an entry opening configured for allowing the prosthesis to selectively pass therethrough when the prosthesis is inserted into the delivery sleeve. A tapered free end of the exit portion provides an exit opening configured for allowing the prosthesis to selectively pass therethrough when the prosthesis is expelled from the delivery sleeve.

The present disclosure in one aspect provides a sterile packaging container comprising a container body with a cross-sectional shape that is constant along the majority of the longitudinal axis, a cover and a closure assembly that inhibits the passage of microbial contaminants. The container is configured such that the interior of the container can be sterilized. The sterile packaging container described herein allows one to manufacture a sterile packaging tube exercising the smallest possible volume.

A meshed, dehydrated, placental tissue allograft that can be used in the treatment of wounds. Specifically, the meshed allograft has the property of being able to be expanded to cover an irregularly shaped wound, therefore reducing the need to apply multiple, uniform sized grafts to a single wound site. The meshed, dehydrated placental tissue allograft is sourced from a human donor, and is then processed to remove any potential contaminants or microbes prior to applying a specific mesh pattern to the tissue. The meshed, dehydrated, placental tissue graft is reconstituted prior to applying to the subject, and can then be configured to optimally cover the shape of the wound site.

An organization device for maintaining a suspensory graft fixation device (i.e., an implant and suture) in a desired position. The device includes a substrate having top and bottom edges with first and second panels extending therebetween. The device also includes a first central longitudinal axis extending in a direction from the top edge to the bottom edge between the first and second panels. The first and second panels are foldable about the axis between open and closed positions. The device also includes an opening extending through the bottom edge and into the first panel, and a plurality of top slits and bottom slits. The plurality of top slits includes at least one top slit which is aligned with the first opening. The device additionally includes a tabs adjacent the opening. The slits and tabs are configured to maintain suture of a suspensory graft fixation device in an organized manner.

A packaging with a packaging arrangement and at least one product received therein, such as in particular a medical product, and a method for manufacturing the packaging are disclosed. The packaging arrangement has a first packaging element, which has a trough-shaped receiving space for receiving the product, wherein the receiving space is delimited by a receiving base and a peripheral wall, which is connected with the receiving base. The packaging arrangement has a second packaging element inserted into the receiving space, which element has a plastically deformable deformation region and a plug-in region which extends peripherally around the deformation region and spans the same, wherein the product is arranged between the deformation region and the receiving base and the deformation region is at least plastically deformed in sections complementarily to the product, by contacting the same. The product is elastically clamped between the receiving base and the deformation region.

A surgical instrument system includes a commonly-sized orthopaedic surgical instrument assembly for use in implanting a femoral component, along with a number of orthopaedic surgical instrument assemblies having varying sizes of instruments of use in implanting a tibial tray component and a patella component.

Cardiovascular prostheses that include an ECM-mimicking composition, which is adapted to induce modulated healing of damaged or diseased cardiovascular tissue and, thereby, associated structures, when administered thereto. The ECM-mimicking composition includes a polymer component and a pharmacological component. The polymer component includes poly(glycerol sebacate) (PGS). The pharmacological component includes a corticosteroid. The ECM-mimicking composition can also include a biological component having a biologically active agent, such as an exosome, a cytokine and a growth factor.