Multi-filter endolumenal methods and systems for filtering fluids within the body. In some embodiments a multi-filter blood filtering system captures and removes particulates dislodge or generated during a surgical procedure and circulating in a patient's vasculature. In some embodiments a dual filter system protects the cerebral vasculature during a cardiac valve repair or replacement procedure.

Multi-filter endolumenal methods and systems for filtering fluids within the body. In some embodiments a multi-filter blood filtering system captures and removes particulates dislodge or generated during a surgical procedure and circulating in a patient's vasculature. In some embodiments a dual filter system protects the cerebral vasculature during a cardiac valve repair or replacement procedure.

Embodiments described relate to a medical device including an invasive probe such as a guidewire that, when inserted into a duct (e.g. vasculature) of an animal (e.g., a human or non-human animal, including a human or non-human mammal), may be used to aid in diagnosing and/or treating a lesion of the duct (e.g. a growth or deposit within vasculature that fully or partially blocks the vasculature). The invasive probe may have one or more impedance sensors to sense characteristics of the lesion, including by detecting one or more characteristics of tissues and/or biological materials of the lesion. There is further described a method of assembling such a medical device.

A method for treating hypertrophic cardiomyopathy (HCM) utilizes an RF ablation electrode needle system that has an RF ablation generator, and an electrode needle. The distal end of the electrode needle is introduced to puncture within myocardium after piercing through epicardium and then advanced along an intramyocardial pathway between endocardia at two lateral sides of the interventricular septum to reach a hypertrophic area of an interventricular septum. The RF ablation generator is then turned on to implement single-point or multi-point ablation on the hypertrophic area of the interventricular septum, and then the RF electrode needle is withdrawn from the patient.

A method for treating hypertrophic cardiomyopathy (HCM) utilizes an RF ablation electrode needle system that has an RF ablation generator, and an electrode needle. The distal end of the electrode needle is introduced to puncture within myocardium after piercing through epicardium and then advanced along an intramyocardial pathway between endocardia at two lateral sides of the interventricular septum to reach a hypertrophic area of an interventricular septum. The RF ablation generator is then turned on to implement single-point or multi-point ablation on the hypertrophic area of the interventricular septum, and then the RF electrode needle is withdrawn from the patient.

Embolic material capture catheters and related devices and methods constrain a distal end portion of an embolic material capture element in an insertion configuration. A method of deploying an embolic material capture element in a blood vessel includes constraining a distal end portion of the embolic material capture element in an insertion configuration via engagement with a dilator assembly. The embolic material capture element, in the insertion configuration, is advanced through the blood vessel. A deployment cap of the dilator assembly is distally advanced relative to a dilator sheath of the dilator assembly to release the distal end portion of the embolic material capture element from engagement with the dilator assembly to reconfigure the embolic material capture element from the insertion configuration to a fully deployed configuration via self-expansion of the embolic material capture element.

A method may include positioning a first device within an internal carotid artery of a subject and impeding antegrade blood flow in the internal carotid artery. Additionally, the method may include delivering a pharmaceutical agent through an external carotid artery for passage into an ophthalmic artery of the subject.

An intravascular filter for blocking passage of embolic debris into the cerebral and aortic circulation upon removal of the cross clamp from the aorta during open heart surgery. The filter comprises a self expandable tubular wire frame, having a proximal end, a distal end and a lumen defined within a tubular sidewall. A tubular porous membrane is carried by the sidewall and extends across the proximal or distal end, so that debris entering the other end can be captured within the lumen, the membrane having a distribution of pore sizes. A control wire extends proximally from the filter. In use, the aorta may be cross clamped over the control wire or over the filter. Following removal of the cross clamp, blood is allowed to perfuse through the membrane in the direction of the descending aorta while retaining embolic debris therein for subsequent removal, and the filter and debris may be proximally retracted using the control wire.

An intravascular filter for blocking passage of embolic debris into the cerebral and aortic circulation upon removal of the cross clamp from the aorta during open heart surgery. The filter comprises a self expandable tubular wire frame, having a proximal end, a distal end and a lumen defined within a tubular sidewall. A tubular porous membrane is carried by the sidewall and extends across the proximal or distal end, so that debris entering the other end can be captured within the lumen, the membrane having a distribution of pore sizes. A control wire extends proximally from the filter. In use, the aorta may be cross clamped over the control wire or over the filter. Following removal of the cross clamp, blood is allowed to perfuse through the membrane in the direction of the descending aorta while retaining embolic debris therein for subsequent removal, and the filter and debris may be proximally retracted using the control wire.

Systems and methods can remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism (PE), deep vein thrombosis (DVT), cerebrovascular embolism, and other vascular occlusions.