The present invention provides improved intravaginal drug delivery devices, i.e., intravaginal rings, useful for the prophylactic administration of dapivirine in combination with either an antimicrobial compound or a contraceptive to a human. The present invention also provides methods of blocking DNA polymerization by an HIV reverse transcriptase enzyme, methods of preventing HIV infection in a female human, methods of treating HIV infection in a female human, methods of preventing unintended pregnancy in a female human, and methods of preparing intravaginal rings.

The present invention provides improved intravaginal drug delivery devices, i.e., intravaginal rings, useful for the prophylactic administration of dapivirine in combination with either an antimicrobial compound or a contraceptive to a human. The present invention also provides methods of blocking DNA polymerization by an HIV reverse transcriptase enzyme, methods of preventing HIV infection in a female human, methods of treating HIV infection in a female human, methods of preventing unintended pregnancy in a female human, and methods of preparing intravaginal rings.

The present invention is related to a vaginal drug delivery device and to a vaginal diagnostic device that comprises a first and second rigid member, wherein the first and/or second rigid member comprises a reservoir holding a medicament to be delivered, an opening, and a pump for pumping said medicament out of said opening, and/or wherein the first rigid member and/or second rigid member comprises a diagnostic device for performing an intravaginal diagnosis or measurement therefor. The device further comprises a first flexible member and flexible part, wherein at least one of the first flexible member and the flexible part is at least partially elastic having an elasticity such that the device can be squeezed from an extended shape to a collapsed shape. The device is pre-biased to assume the extended shape when little to no external force is being applied thereto. Furthermore, the device assumes a shape substantially corresponding to the extended shape when the device is inserted with the squeezed rigid member first, so that these naturally unfold in the formix posterior vaginae.

Apparatus that enables non-penetrating sex between two users. Embodiments may be integrated into or attached to clothing worn by the first user. A tubular element (including, but not limited to, a male or female condom) may be installed either permanently or detachably; attachments at both the open and closed ends of the tubular element ensure that it will not penetrate the first user. Users may therefore enjoy many of the benefits of sex, including intimacy and mutual stimulation, without the risks inherent in penetration. Attachment for the open end may use for example an element that attaches to a base ring or flange at the open end. Illustrative attachments for the closed end include a loop into which the closed end is cinched, a notch or hole into which a button in the closed end is inserted, and a mechanism into which the closed end is inserted, folded, and secured.

The present invention relates to a novel female condom device. The device is a form of contraception designed to keep women safe during sexual intercourse. The device comprises a body component comprised of a dental dam component and male condom component. Typically, the dental dam component would be a flat, thin sheet of latex or nitrile in a rectangular shape but can be any suitable size/shape. The underside of the body component of the device would comprise an adhesive to keep the device in place during sex, minimizing the transfer of bodily fluids. In position, the flat adhesive dental dam component remains outside the vagina, while the male condom component extends into the vaginal walls, as the male penis is inserted for sexual intercourse. Once in place, the device will reduce transmission of STI and STD for women by a significant percent while also helping prevent or reduce pregnancy.

The present invention relates to a dispensing mechanism (2) for delivery of pharmaceutical forms (4) into body holes and an applicator (I) comprising the novel dispensing mechanism (2). The pharmaceutical form dispensing mechanism (2) Comprises a rod (2A) connected to a flexible member (2B). One end of the rod is free from constraints in order to allow its axial movement. The other end of the rod is cooperatively connected to said flexible member (2B). The flexible member has a rounded or angular shape, being able to be deformed and being provided with shape memory. The flexible member (2B) extends in a direction perpendicular to the direction of a compression force applied to it and recovers its original shape when said compression force is withdrawn, thereby imparting, respectively, a forward or rearward movement to the rod (2A), namely when a part (2C) thereof is immobilized in the body (3) of the applicator.

The present invention relates to a dispensing mechanism (2) for delivery of pharmaceutical forms (4) into body holes and an applicator (I) comprising the novel dispensing mechanism (2). The pharmaceutical form dispensing mechanism (2) Comprises a rod (2A) connected to a flexible member (2B). One end of the rod is free from constraints in order to allow its axial movement. The other end of the rod is cooperatively connected to said flexible member (2B). The flexible member has a rounded or angular shape, being able to be deformed and being provided with shape memory. The flexible member (2B) extends in a direction perpendicular to the direction of a compression force applied to it and recovers its original shape when said compression force is withdrawn, thereby imparting, respectively, a forward or rearward movement to the rod (2A), namely when a part (2C) thereof is immobilized in the body (3) of the applicator.

A garment assembly useful for sexual intercourse between a first user and a second user when the penetration of a body-extending member into a body orifice is either not possible or unwanted. The garment assembly includes a front and back panel covering and a crotch piece with the appearance of an ordinary garment normally found in a public environment such as one having the appearance of underwear. A fluid-impenetrable receiver attached to the front panel of the garment assembly will operate as a substitute for a body-orifice. The receiver includes an entryway adjoined to an interior cavity sized to accommodate a body-extending member. A preferred interior cavity includes sexually-interactive textured material for engagement with the body-extending member during use.

A garment assembly useful for sexual intercourse between a first user and a second user when the penetration of a body-extending member into a body orifice is either not possible or unwanted. The garment assembly includes a front and back panel covering and a crotch piece with the appearance of an ordinary garment normally found in a public environment such as one having the appearance of underwear. A fluid-impenetrable receiver attached to the front panel of the garment assembly will operate as a substitute for a body-orifice. The receiver includes an entryway adjoined to an interior cavity sized to accommodate a body-extending member. A preferred interior cavity includes sexually-interactive textured material for engagement with the body-extending member during use.

There is provided a method for controlling a flow of sperms in a uterine tube formed by a uterine tube wall of a patient. The method comprises gently constricting (i.e., without substantially hampering the blood circulation in the uterine tube wall) at least one portion of the uterine tube wall to influence the flow of sperms in the uterine tube, and stimulating the constricted wall portion to cause contraction of the uterine tube wall portion to further influence the flow of sperms in the uterine tube. The method can be used for restricting or stopping the flow of sperms in the uterine tube, or for actively moving the fluid in the uterine tube, with a low risk of injuring the uterine tube.