A temperature gradient chromatography, and apparatus for the same, said method comprising the following: a) dissolving a composition comprising at least one polymer in at least one solvent, to form a polymer solution; b) injecting at least a portion of the polymer solution onto a support material and wherein the support material has a CI from 0.70 to 1.50; c) cooling the support material at a rate greater than, or equal to, 0.2 C./min; d) increasing the temperature of the support material to elute at least some of the polymer; e) generating the chromatogram.

The disclosure includes systems and methods of producing cannabidiol (CBD) isolate. In some embodiments, a method includes dissolving CBD oil in a solvent to thereby form a slurry comprising a CBD isolate and excess solvent. Methods may thereby include separating, via a centrifuge, at least a portion of the CBD isolate from the excess solvent to thereby form a separated batch. Additionally, some embodiments include drying the CBD isolate from the separated batch.

A method of desalinating an aqueous composition includes forming a hetero-azeotrope mixture by combining the aqueous composition with an entrainer, the aqueous composition including at least one salt, and subjecting the hetero-azeotrope mixture to distillation at a distillation temperature of less than the boiling temperature of the aqueous composition for an operating distillation pressure, resulting in separating the hetero-azeotrope mixture into a distillation bottoms liquid and a multi-phase condensate. The method includes recovering the multi-phase condensate having an entrainer-rich phase and an aqueous phase, the aqueous phase comprising desalinated water, and removing a portion of the aqueous phase from the multi-phase condensate to recover the desalinated water. Systems for conducting the method of desalinating an aqueous stream are also disclosed.

The present invention relates to the use of cannabidiol (CBD) in the treatment of focal seizures. In one embodiment the patients suffering from focal seizures are children and young adults. CBD appears particularly effective in reducing focal seizures in patients suffering with etiologies that include: Lennox-Gastaut Syndrome; Tuberous Sclerosis Complex; Dravet Syndrome; CDKL5; Neuronal ceroid lipofuscinoses (NCL); febrile infection related epilepsy syndrome (FIRES); Aicardi syndrome and brain abnormalities in comparison to other seizure types. Significantly CBD additionally is very effective in the reduction of a sub-type of focal seizures, focal seizures with impairment.

The present invention describes a process for the production of ()-cannabidiol (CBD) from industrial hemp by means of an extraction followed by two alternative working processes: a process A which provides extraction with solvents first to an alkaline pH and then to acidic pH to isolate the carboxyl form of the CBD which is then subjected to decarboxylation and a process B which provides the elimination of waxes and pitches and then purification by chromatography. At the end of both alternative working processes the CBD is crystallized obtained in high purity crystalline form.

The present invention provides a continuous crystallization method under control of the multistage membrane modules, and belongs to the technical field of crystallization engineering. A crystallization solution is added to a crystallizer, and a stirring apparatus and a temperature control apparatus are started. After the system running stability, the loop of crystallization is started. Meanwhile, the coolant or antisolvent feed liquid loop is also started. The crystallization solution can respectively conduct crystal nucleation, growth and ripening in the multistage membrane modules, and then the crystallization solution is transported into a filter device and a drying apparatus to obtain the final crystal products. The desired crystal products can be obtained by the systematical control of the nucleation and crystal growth through the flow and the temperature of the crystallization solution, coolant or antisolvent feed liquid, and the contact time between two liquid phases.

The invention relates to a processing device in the form of a crystallizer or reactor comprising a tube, at the opposite end regions of which an inlet and an outlet are provided for a crystallization or reaction medium. A helixical web is provided which runs about a longitudinal axis of the tube and which rests against the inner face of the tube casing, and the web is mounted so as to be rotatable about the aforementioned longitudinal axis of the tube. The device also has a drive for rotating the web.

The present invention provides a continuous crystallization method under control of the multistage membrane modules, and belongs to the technical field of crystallization engineering. A crystallization solution is added to a crystallizer, and a stirring apparatus and a temperature control apparatus are started. After the system running stability, the loop of crystallization is started. Meanwhile, the coolant or antisolvent feed liquid loop is also started. The crystallization solution can respectively conduct crystal nucleation, growth and ripening in the multistage membrane modules, and then the crystallization solution is transported into a filter device and a drying apparatus to obtain the final crystal products. The desired crystal products can be obtained by the systematical control of the nucleation and crystal growth through the flow and the temperature of the crystallization solution, coolant or antisolvent feed liquid, and the contact time between two liquid phases.

A system for generating a concentrated product from a feedstock includes a feedstock chamber to which the feedstock is provided, a heat exchanger assembly in thermal communication with the feedstock chamber, the heat exchanger assembly being configured to freeze the feedstock in the feedstock chamber, an output flow arrangement configured to carry liquid from the feedstock chamber as the feedstock thaws, the output flow arrangement comprising a flow controller, a sensor disposed along the output flow arrangement or the heat exchanger assembly, the sensor being configured to measure a characteristic of the liquid, the characteristic being indicative of a solute concentration level of the liquid or the heat exchanger assembly, and a processor responsive to the characteristic and configured to control the flow controller to, based on the solute concentration level, direct the liquid passing through the output flow arrangement to define a plurality of products at different concentration levels, the plurality of products comprising the concentrated product.

A dynamic process for purifying dicyclopentadiene from a mixed liquid hydrocarbon stream comprising dicyclopentadiene and one or more of a C.sub.5 paraffin, a C.sub.5 olefin, co-dimers, cyclopentadiene, benzene, vinyl norbornene, bicyclononadiene, propenyl norbornene, isopropenyl norbornene, methylbicyclononadiene, methyldicyclopentadiene, and various minor organic impurities is introduced, wherein the dicyclopentadiene is separated from the mixed liquid hydrocarbon stream by melt crystallizing sweating and collecting dicyclopentadiene.