Devices, systems and methods for controlling a patient's body temperature by endovascular heat exchange.

Disclosed herein is a system, apparatus and method directed to an expandable and conformable targeted temperature management (TTM) pad. The system, apparatus and method pertain to a medical pad for exchanging thermal energy between a TTM fluid and a patient. The pad includes an insulating layer, a fluid containing layer for containing the TTM fluid, and a patient contact surface. The fluid containing layer is configured for circulating the TTM fluid. The patient contact surface defines a first patient contact area to facilitate thermal energy exchange with the patient. One or more slits are arranged in at least the insulating layer of the pad to facilitate stretching the pad and conforming to a contour of a patient's anatomy. The stretching can expand the patient contact surface to a larger second patient contact area. The pad can further include a flexible fabric cover.

A peristaltic pump has an arcuate raceway with a partially concave inner surface extending through an arc of at least one hundred eighty degrees (180°). The arc defines a midpoint, and a rotor faces the inner surface of the raceway and is both rotatable relative to the raceway and translationally movable relative to the raceway between a pump position, wherein the rotor is spaced from the midpoint a first distance, and a tube load position, wherein the rotor is spaced from the midpoint a second distance greater than the first distance. A rotor motor is coupled to the rotor to rotate the rotor and rollers arranged on the rotor to contact tubing disposed between the rotor and the raceway when the rotor is in the pump position. A loading motor moves the rotor toward and away from the raceway.

An improved medical pad for contact thermal exchange with a patient includes a fluid circulation layer for containing a thermal exchange fluid circulatable therethrough, a first port and a second port for circulating the thermal exchange fluid in to and out of the fluid circulation layer, and a hydrogel layer interconnected to and extending across one side of the fluid circulation layer to define an adhesive surface for adherence to a patient's skin. The hydrogel layer comprises an ultra violet light-cured composition that includes a cross-linking copolymer in an amount of between about 15% to 30% by weight of the composition, water in an amount of between about 15% to 40% by weight of the composition, and glycerol in an amount of between about 25% to 35% by weight of the composition. The hydrogel layer is provided to have a thermal conductivity of at least about 1.9 cal/hr-cm-° C.

Systems, methods and devices for utilizing heat transfer parameters or energy expenditure of devices providing controlled hypothermia, normothermia or hyperthermia to detect changes, or the absence of changes, a patient's endogenous set-point temperature; which is not available during exogenously induced targeted temperature management. A particular embodiment would allow detection of fever in patients undergoing targeted temperature managed.

A system and method for hyperthermic ablation of cancerous tissue of a human patient is disclosed. A system and method include a vessel that is sized and adapted for receiving the human patient, and a circulation device outside of the vessel for circulating a thermally conductive liquid to and from the vessel, such that the portion of the human patient enclosed in the containment suit is at least partially submerged in the thermally conductive liquid when the human patient is in the vessel. The system and method further include a set of electromagnetic transmission coils at least partially around the vessel for inducing an alternating electromagnetic field around the human patient, the alternating electromagnetic field being directed, via the thermally conductive liquid, to the cancerous tissue that has been provided a conductive nanoparticle, to provide hyperthermic ablation of the cancerous tissue.

A thermal control unit for controlling the temperature of a patient includes a fluid circulation channel with an inlet and outlet, a first heat exchanger, a controller, and a cartridge receptacle. The controller controls the first heat exchanger to adjust the temperature of the circulating fluid toward a desired temperature. The cartridge receptacle is adapted to receive a cartridge having a second heat exchanger and to allow fluid to flow from the cartridge into the fluid circulation channel of the thermal control unit. The cartridge may include a vacuum chamber and a coolant whereby the expansion of the coolant into the vacuum chamber cools the fluid in the cartridge. Flow of the coolant in the vacuum chamber may be automatically initiated upon insertion of the cartridge into the cartridge receptacle, or by other means.

A thermal transfer device for providing thermal treatment to a patient. A patient support portion supporting and contacting the patient includes a first segment of a fluid flow path to receive a fluid from a fluid source. A flexible covering coupled and movable relative to the patient support portion defines a space therebetween that substantially conforms to the patient. The flexible covering includes a second segment of the fluid flow path. The fluid is circulated through an inlet, an outlet, and fluid flow path for supplying heat to or removing heat from the patient support portion and the flexible covering. A fluid circulation system with a controller may selectively adjust heat transfer from temperature zones defining the patient support portion. The thermal transfer device or a mattress cover may provide for controlling the microclimate, or conditions at or near the interface between the patient and the patient support portion.

A topical cooling compressive hemostasis wound healing device and methods thereof for affecting a percutaneous access site wound or an acute surgical wound. The device delivers and transports cooling to affect and control vasculature and musculoskeletal motions surrounding the injury site during the blood coagulation, hemostasis, and wound healing phases. The device has a viscoelastic and thermally conductive surface to deliver and transport an adjustable compressive pressure to resist outward blood flow, thus improving patient safety and clinical outcomes. The device is anatomically conforming and treats not only the specific injury site, but also its surrounding anatomical structures together as means to prevent unpredictable delayed hemostasis breach. The device provides comfort to the patient by allowing mobility upon wound healing, thus reducing back pain and strain resulting from being in a constrained position for a prolonged period of time which is known to cause additional medical events. The device reduces pain, inflammation, swelling, and scar formation on the injury site of a patient and promotes hemostasis, sustains hemostasis, and improves overall wound healing quality.

Disclosed herein are targeted temperature management (“TTM”) systems, pads, and methods thereof for treating burn wounds. A method of a system for TTM can include a pad-connecting step, a pad-placing step, and a fluid-circulating step. The pad-connecting step can include connecting an inlet and an outlet of a pad to a hydraulic system of a control module. The pad can include a multilayered pad body having a conduit layer configured to convey a temperature-controlled fluid provided by the control module. The pad-placing step can include placing the pad on a wounded portion of a patient's body with a sterile, thermally conductive wound-healing layer of the pad body in contact with a burn wound of the wounded portion of the patient's body. The fluid-circulating step can include circulating the temperature-controlled fluid through the conduit layer to cool the wounded portion of the patient's body, thereby treating the wound to promote healing.