Disclosed is a continuous process for the purification of steviol glycosides such as Rebaudioside D and/or Rebaudioside M extracted from the dried stevia leaves or extracted from a fermentation broth using continuous simulated moving bed processes and nanofiltration without the addition of organic solvents to obtain a purified steviol product comprising sweet steviol glycosides. The sweet steviol glycosides can be used as substitutes for caloric sweeteners in beverages and in other food items.

Textile compositions comprising at least one filamentous fungus are disclosed, as are methods for making and using such textile compositions. Embodiments of the textile compositions generally include at least one of a plasticizer, a polymer, and a crosslinker, in addition to the filamentous fungus. The disclosed textile compositions are particularly useful as analogs or substitutes for conventional textile compositions, including but not limited to leather.

Methods and apparatus for the improved extraction of compounds from a charge material are disclosed. The improved extraction is achieved at least a bypass line that permits the transfer of sCO.sub.2 and/or CO.sub.2 to an extraction vessel and a hopper that achieves greater productivity in loading the extraction vessel.

The invention relates to methods of separating or isolating a component from a plant using freeze separation. The invention includes products produced by said methods.

Formation of low-crystallinity phytosterol nanoparticles via cooling-controlled supercritical carbon dioxide (SC—CO.sub.2) impregnation of phytosterols into biodegradable nanoporous starch aerogels and methods of preparing these aerogels are disclosed. The nanoporous starch aerogels increase water dissolution and bioaccessibility of the phytosterols, thereby making them available for preparation of high nutraceutical value foods.

Provided is an extraction method for extracting an extract from a mixture using liquefied gas that can dissolve the extract, the method facilitating extraction operations and enabling low cost operation. An extraction device that extracts a component dissolved in liquefied gas from material to be treated using continuous phase changes in the liquefied gas is characterized by being provided with: a compressor that feeds gas under pressure; a heat exchanger for generating liquefied gas by the gas flowing in a high temperature side flow path; a treatment tank into which the material to be treated is loaded and the liquefied gas flows; and a retention tank provided in series or in parallel to the flow path downstream of the high temperature side flow path in the heat exchanger.

The present invention relates to the use of cannabidiol (CBD) in the treatment of focal seizures. In one embodiment the patients suffering from focal seizures are children and young adults. CBD appears particularly effective in reducing focal seizures in patients suffering with etiologies that include: Lennox-Gastaut Syndrome; Tuberous Sclerosis Complex; Dravet Syndrome; CDKL5; Neuronal ceroid lipofuscinoses (NCL); febrile infection related epilepsy syndrome (FIRES); Aicardi syndrome and brain abnormalities in comparison to other seizure types. Significantly CBD additionally is very effective in the reduction of a sub-type of focal seizures, focal seizures with impairment.

Cannabidiol (CBD) is a cannabinoid designated chemically as 2-[(IR,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol. Its empirical formula is C.sub.21H.sub.30O.sub.2 and its molecular weight is 314.46. CBD is a cannabinoid that naturally occurs in the Cannabis sativa L. plant. CBD is a white to pale yellow crystalline solid which is insoluble in water and soluble in organic solvents. The present invention encompasses the surprising recognition that certain CBD preparations which are prepared from a botanical origin are more effective in treating diseases or disorders than preparations of CBD which are synthetic or purified to the extent no other impurities in the form of other cannabinoids are present. Prior CBD compositions have been prepared such that no psychoactive components, e.g., tetrahydrocannabinol (THC), remain in the final CBD preparation. Surprisingly, the absence of such minor impurities reduces the efficacy of CBD treatment. Such CBD preparations are characterized by chemical components and/or functional properties that distinguish them from prior CBD compositions. One or more components of the preparations described herein provide an unexpectedly synergistic effect when utilized in combination.

According to the invention, there is provided novel hemp Cannabis cultivars with THC content of 0.2% by dry weight and a unique terpene profile. The cultivars exhibit increased CBD content of greater than about 1.07% by weight. The plants also have increased plant height and decreased branching that allows for increased yields of hemp and CBD content per acre. This invention thus relates to the seeds of hemp Cannabis cultivars of the invention, to the plants of hemp Cannabis cultivars of the invention, to plant parts of hemp Cannabis cultivars of the invention, to methods for producing a Cannabis cultivar by crossing the hemp Cannabis cultivars of the invention with another Cannabis cultivar, and to methods for producing a Cannabis cultivar containing in its genetic material one or more backcross conversion traits or transgenes and to the backcross conversion Cannabis plants and plant parts produced by those methods.

A system for extracting components from sample material includes a multi-port extraction vessel and an extraction basket that is configured to hold the sample material and to be rotated within the multi-port extraction vessel. The extraction vessel may include multiple ingress ports and multiple egress ports to allow a liquid solvent to flow through the extraction vessel during an extraction process. The extraction basket is permeable to allow liquid solvent to flow through the extraction basket and distribute throughout the sample material held within the extraction basket. A rotation mechanism, such as a motor, may rotate the extraction basket within the extraction vessel during the extraction process. The multi-port extraction vessel, in combination with the rotatable extraction basket, promotes even distribution of the liquid solvent throughout the sample material.