Certain substances (e.g., large molecules) that ordinarily cannot traverse the cell membrane of cells can be introduced into cells by applying an alternating electric field to the cell for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the cell membrane. Once the permeability of the cell membrane has been increased, the substance is able to cross the cell membrane. This approach is particularly useful in the context of cancer cells (e.g., glioblastoma).

A cooling device for removing heat from subcutaneous lipid-rich cells of a subject having skin is provided. The cooling device includes a support having a first portion and a second portion. A first cooling element having a first heat exchanging surface is located at the first portion of the support. A second cooling element having a second heat exchanging surface is located at the second portion of the support. At least one of the first and second cooling elements is movable along the support and is configured to rotate for adjusting an angle between the first and second heat exchanging surfaces.

A handpiece including a cooling device for a skin care device used for improving or treating a skin. The handpiece includes: a case; a cooling head part mounted at a fore-end inside the case and configured to generate cooling energy; a cooling plate part which has a rear end for receiving the cooling energy from the cooling head part and has a fore-end that cools a treatment site through the contact with the skin; a needle part which includes needles for penetrating into the skin during the procedure for skin care; and a linear motor unit which includes a driving unit configured to penetrate the cooling head part is coupled to the needle, and a motor unit located at a rear of the cooling head part and inducing a linear movement of the needle part by a forward and backward movement of a driving unit.

We report a method of treating an epileptic seizure in a patient, comprising: detecting said epileptic seizure, based on body data from said patient; and reducing a flow of blood to a brain of said patient in response to said detected seizure; wherein said reducing is effected by: increasing the parasympathetic input to said patient's heart, such as by electrically stimulating a parasympathetic nervous structure, applying cooling energy to a sympathetic nervous structure, or administering a cholinergic or a sympatho-blocking agent to said patient. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.

A heat transfer device particularly structured for application of thermal therapy from a contact surface to a human ear. A device may be passive (pre-cooled), active (thermoelectrically active), or include elements of both. A device may be structured to apply thermal treatment from a contact surface of a contact cavity only to a localized posterior area relative to the circumference of an ear. Preferably, a device provides an uninterrupted opening extending in a line-of-sight between an ear canal and the local environment. A device may include both of a contact cavity and a bulk cavity, with heat transfer media disposed in each cavity. Typically, a bulk cavity holds at least twice the media volume contained in a contact cavity. The cavities may be disposed in fluid communication, or separated by a barrier to permit only thermal communication there-between. When a barrier is present, a device may include different heat transfer media in each cavity. One or more device may be associated with various mounting structure to dispose a contact surface in contact with desired portion(s) of a head.

A device for providing vestibular and somatosensory stimulation through bone conduction of sound waves to skeletal bones is provided in the form of a pad that is applied to or wrapped around the individual in treatment, which is comfortable in use and may contain particulate filler material capable of providing bone conduction stimulation adjacent to the location of a bone conduction transducer and expand the sound conduction site over a larger area. The device may be located beneath a pillow or mattress.

Treatment systems, methods, and apparatuses for improving the appearance of skin or other target regions are described. Aspects of the technology are directed to improving the appearance of skin by tightening the skin, improving skin tone or texture, eliminating or reducing wrinkles, increasing skin smoothness, or improving the appearance sites with cellulite. Treatments can include cooling a surface of a patient's skin and detecting freezing in the cooled skin. The tissue can be cooled after the freeze event is detected so to maintain the frozen state of the tissue to improve the appearance of the treatment site.

A control unit and methods for operating the control unit to perform non-contact radio-frequency (RF) heating of a fluid flowing through or contained within a non-contact radio-frequency heating element.

A thermostatic massage pad includes: a thermostatic pad, wherein a thermostatic water pipe is arranged inside the thermostatic pad; a cooling pad, wherein a cooling water pipe is arranged inside the cooling pad; a casing, wherein a thermostatic water pump and a cooling water pump are respectively arranged inside the casing, a thermostatic water tank is arranged at a top of the thermostatic water pump, a cooling water tank is arranged at a top of the cooling water pump, a water inlet end of the thermostatic water pump is connected to a water outlet of the thermostatic water tank, and a water inlet end of the cooling water pump is connected to a water outlet of the cooling water tank; a thermoelectric cooler, wherein an end surface of the thermoelectric cooler is fixedly connected to a wall surface of the thermostatic water tank.

Methods for treating Blepharitis, Meibomian Gland Dysfunction and Dry Eye Syndrome include thermal massage, thermal debridement, and thermal expression. Particular embodiments include use of handheld devices that provide the thermal therapy to tissue by contacting a surface heated with thermal energy to a patient's tissue. Thermal energy can be continuously provided during operation. In particular embodiments, a handheld device comprises a base assembly operatively connected to a removeable thermal energy applicator. A wide range of thermal applicators may be connected to the base assembly to provide different treatments, including heat application, debridement, and expression of the treated tissue or gland.