Provided herein are systems, compositions, and methods for improving one or more skin characteristics in a subject. These systems, compositions, and methods are configured to cool the subject's skin at a target site to a degree that alters adipocyte signaling but does not produce significant destruction of subcutaneous lipid-rich cells. In some embodiments, alteration of adipocyte signaling produces an improvement in one or more skin characteristics.

A multi layer advanced heating pad comprising a reflective layer proximate to a heating layer and a black body a layer configured to concentrate and amplify heat emitted from the heating layer and reflected by the reflective layer.

A rejuvenating beauty care tool for skin and body is an apparatus that enables the user to treat different skin and body areas using different therapeutic and cosmetic techniques. The apparatus may include a handle, a first arm, a second arm, a plurality of first rollers, and a plurality of second rollers. The handle enables the user to comfortably operate the apparatus using only one hand. The handle also supports the first arm and the second arm when the first arm and the second arm are pressed against the user's body. The first arm presses the plurality of first rollers against a first target body area. Likewise, the second arm presses the plurality of second rollers against a second target body area. Further, both the plurality of first rollers and the plurality of second rollers enable the application of the desired cosmetic or therapeutic treatment onto the target body areas.

Methods are provided herein for affecting a region of a subject's body, comprising exposing the region to a cooling element under conditions effective to cool subcutaneous adipose tissue in said region; and increasing the blood flow rate to the cooled tissue by exposing the tissue to an energy source. Methods are also provided for treating subcutaneous adipose tissue in a region of a subject's body, comprising exposing said region to a cooling element under conditions effective to cool said tissue; and exposing the tissue to an energy source to increase the blood flow rate to the cooled tissue, thereby stimulating reperfusion in, and/or causing an ischemia-reperfusion injury to, the cooled tissue.

Methods systems and apparatus are set forth herein. There is provided in one embodiment determining one or more body physiological parameter of a patient based on one or more input; and controlling a heating system for warming the patient based on a result of the determining.

A skin treatment apparatus, such as a microdermabrasion or dermaplaning apparatus, includes a housing having a top end and a bottom end, a treatment head attached to the top end of the housing and arranged to exfoliate skin within a treatment area, and a cooling member provided on the bottom end of the housing arranged to cool skin within the treatment area.

Methods and systems for providing distributed vibration therapy. The vibration device includes a plurality of vibration motors that are located along a grid. The vibration motors are embedded on a basal pad. A primary diffuser overlays the embedded the vibration motors. The device is portable and can be adaptable to a target body part.

A method for killing or damaging cancerous cells in a living body comprising introducing glucose or other organic material as a biasing component into heating cancerous cells for purposes of destroying the cancerous cells with a second method of heating, such as by bombardment of energy from an external electromagnetic source, so as to raise the temperature of the tumor or cancerous cells to a degree that they are damaged or expire.

A Meibomian Gland Roller system allows for self-administered the treatment for a leading cause of dry eyes, namely, tear film oil deficiency. The system combines an effective and safe technique to combine mechanical rolling pressure with heat for meibomian gland drainage. The rolling action of the roller cylinder combined with the roller head to increase effectiveness in empting inspissated meibomian glands. The roller allows the patient to safely start the application of the pressure at the bottom of the glands and effectively roll open clogged oil glands. The washable roller keeps the head clean for long term use. A preheated eye-shaped soft gel pad can prepare the lids before the roller tip is applied by heating and softening the meibomian gland contents, allowing the roller to have a more effective action to induce mechanical extraction of the gland content.

Methods for treating Blepharitis, Meibomian Gland Dysfunction and Dry Eye Syndrome include thermal massage, thermal debridement, and thermal expression. Particular embodiments include use of handheld devices that provide the thermal therapy to tissue by contacting a surface heated with thermal energy to a patient's tissue. Thermal energy can be continuously provided during operation. In particular embodiments, a handheld device comprises a base assembly operatively connected to a removeable thermal energy applicator. A wide range of thermal applicators may be connected to the base assembly to provide different treatments, including heat application, debridement, and expression of the treated tissue or gland.