A treatment system for cooling subcutaneous lipid-rich cells in a human subject includes an applicator and a control unit. The treatment system has a cooling mode for cooling tissue and a heating mode for warming tissue. The control unit includes a circulation circuit in fluid communication with the applicator, a chiller apparatus configured to chill fluid from the applicator circulation circuit, and a heater apparatus to warmed fluid from the applicator circulation circuit. The control unit mixes the chilled fluid and/or the warmed with fluid in the applicator circulation circuit control the temperature of the fluid circulated in the applicator.

A method and system in accordance with a particular embodiments of the technology includes applying a substance onto skin of a human subject. An applicator is then applied to the subject to cool a region of the subject. After cooling the tissue, a nucleation initiator is used to initiate a freeze event in the tissue. The nucleation initiator can be an ice crystal that inoculates the skin upon contact to create a predictable freeze event therein. The time of contact between the ice crystal and the skin can be controlled to achieve desired effects.

Disclosed are methods of obtaining zero vergence ultrasound waves for providing sonodynamic therapy with ultrasound waves. The method includes coupling a sonodynamic therapy device with an array of flat piezoelectric transducers to a skin surface. A controller is configured to generate an electrical drive signal at a frequency, modulate the drive signal, and drive the transducer with the modulated drive signal at the frequency to produce a zero vergence ultrasound wave to produce an average acoustic intensity sufficient to activate a sonosensitizer in a treatment region without damaging healthy cells in the treatment region.

A rapid contrast therapy system can provide cold, heat/hot/warm (hereafter referred to as “hot”), and/or rapid contrast therapy, which involves rapidly alternating between cold therapy and hot therapy. The system can circulate cold or hot fluid, such as water, through a hose, into a therapy wrap, and then back to the fluid reservoirs of the system. The system can utilize a vapor compression system or other chiller technology to cool the cold water reservoir, and immersion heaters can be used to heat the hot water reservoir.

An improved pain management and post-operative hip orthosis includes a waist strap having first and second ends, a lower strap having first and second ends, and a pocket extending between the waist strap and lower strap. The pocket has inner and outer panels fastened to each other to define an upper opening and a lower opening. A cooling pack including a reservoir and inlet and outlet tubes extending from a bottom of the reservoir is applied to the pocket such that the inlet and outlet tubes pass through the lower opening of the pocket.

The present invention relates to a device for manipulating core body temperature of a human subject by convection and conduction, the device comprising: an open topped liquid carrier vessel adapted to receive a liquid, the liquid carrier vessel having an inlet and an outlet in the base thereof; a removable splash guard for covering the majority of the liquid carrier vessel opening and for resting thereon of a human extremity having an exposed glabrous skin surface; chiller means for cooling liquid received in the vessel and for maintaining the liquid at a predetermined temperature; a jet in the vessel inlet for discharging liquid, or a combination of liquid and air into the liquid carrier vessel; an air valve for controlling the amount of air flowing through the jet; a pump configured to suck liquid from the liquid carrier vessel via the vessel outlet into a suction side of the pump and propel liquid out of a pressure side of the pump into the liquid carrier vessel through the vessel inlet via the chiller means to create a jet stream within the liquid carrier vessel at the predetermined temperature; first conduit means interconnecting the vessel outlet with the suction side of the pump; second conduit means interconnecting the chiller means with the pressure side of the pump; third conduit means interconnecting the chiller means with the jet; and fourth conduit means interconnecting the jet with the air valve; wherein the splash guard is provided with an aperture to allow the jet stream to contact the exposed glabrous skin surface of the subject during operation of the device; and wherein when the splash guard is in place, the aperture is located directly above the jet.

A warming blanket for warming a patient includes a first sheet including a first major surface of the warming blanket, and a second sheet including a second major surface of the warming blanket. The second sheet is sealingly joined to the first sheet to form one or more inflatable portions between the first and second sheets. An adhesive layer is disposed on the first major surface of the first sheet. A liner assembly is disposed on the adhesive layer opposite to the first major surface and fully covers the adhesive layer. The liner assembly includes a plurality of release liners delimited from each other and releasably bonded to the adhesive layer, such that each release liner is independently removable from the liner assembly to expose a corresponding portion of the adhesive layer. Each of the first sheet, the adhesive layer, and the plurality of release liners is air-permeable.

Disclosed is a system and method for producing and storing hot air, and for applying the stored hot air to a human body. The hot air producing system may include a heating apparatus configured to heat air to a temperature, a temperature setting gauge, a pressure gauge, a pump to pump the hot air, a fill connection, a container for receiving hot air from the heating apparatus and storing the hot air therein, the container including at least one valve to connect to the fill connection of the heating apparatus such that the container can receive the hot air from the heating apparatus, an adjustable flow release mechanism connected to an outlet of the container for receiving the hot air, and a flexible hose connected to the adjustable flow release mechanism. Embodiments of the invention can include a computer system capable of governing all the components.

Disclosed herein is a method to enable a user to use a hypothermia system to cool a body part involved in cancer therapy or in brain trauma. The method enables the user to operate the hypothermia system by her- or himself and still be mobile. The hypothermia system comprises a conformal cap system, a thermally conductive liquid located between the body part to be cooled and the cap system, thermal transfer fluids, phase change materials, thermally insulated cooler, physical measuring devices, mechanical and electrical components, a ‘smart’ user interface device, a battery, and an uninterruptible power controller. The method allows a user to control the rate of and temperature of cooling down the body part, exhibits parameters associated with the process of cooling the body part, provides alerts if necessary, is portable and entirely self-managed. The hypothermia device is in communication with and can be controlled by an application installed on a smart device, such as a phone. The method of using the hypothermia system can help to eliminate hair loss caused by the side effects of certain chemotherapy treatments or to reduce the metabolic rate of ischemic tissue to prevent or minimize the severity of swelling.

Disclosed herein are systems, pads, and methods for targeted temperature management. For example, a pad can include a multilayered pad body, a pad inlet connector, and a pad outlet connector. The pad body can include a conduit layer and a non-adhesive, thermally conductive layer over the conduit layer. The conduit layer can include one or more conduits configured to convey a temperature-controlled fluid as a supply fluid from a hydraulic system of a control module. The one-or-more conduits can also configured to convey the temperature-controlled fluid as a return fluid back to the hydraulic system. The conductive layer can be configured for placement on a portion of a patient's body. The pad inlet connector can include a pad inlet configured for charging the conduit layer with the supply fluid. The pad outlet connector can include a pad outlet configured for discharging the return fluid from the conduit layer.