The present invention generally relates to improved medical devices, systems, and methods, with exemplary embodiments providing improved cooling treatment probes and cooling treatment methods and systems. In some embodiments, freezing of the skin may be desirable to effect the hypopigmentation of the skin of the patient. Generally, embodiments may limit supercooling of the skin of the patient during a cooling treatment. Additionally, embodiments may limit adverse side effects such as hyperpigmentation. It has been found that the freezing behavior (frequency and time to freeze) can be modified by adjusting the thermal parameters of the cooling applicator. Accordingly, in some aspects of the invention, a method of treating the skin may be provided where the thermal parameters of the cooling applicator are adjusted during treatment.

Medical devices, systems, and methods for pain management and other applications may apply cooling with at least one probe inserted through an exposed skin surface of skin. The cooling may remodel one or more target tissues so as to effect a desired change in composition of the target tissue and/or a change in its behavior, often to interfere with transmission of pain signals along sensory nerves. Alternative embodiments may interfere with the function of motor nerves, the function of contractile muscles, and/or some other tissue included in the contractile function chain so as to inhibit muscle contraction and thereby alleviate associated pain. In some embodiments, other sources of pain such as components of the spine (optionally including herniated disks) may be treated.

A pain-reducing injection apparatus to enhance the safety, efficacy, and efficiency of injection procedures which utilize topical pain-reducing measures. Apparatuses and methods of use provide pain reduction through thermal cooling of an injection region or vibrating the region or both, and optionally include safety shielding and lockout features.

Methods and devices with noninvasive means for improving health such as treating itching especially skin itchiness are described. The non-invasive means is selected from electrical stimulation, heat or cold stimulation, IR (infrared) radiation, mechanical stimulation or their combinations. In some embodiments, the method and device utilizes electrical current passed through skin including the site having itchy feeling to achieve the desired therapeutical and beneficial effects.

A hand-held or wearable device for cooling tissue of an eye of a patient is disclosed. In one aspect, the device includes a reservoir having fluid therein and a support connected to the reservoir and configured to be positioned on a face of the patient. The device also includes a nozzle positioned proximate to the support and fluidically connected to the reservoir, the nozzle configured to pass the fluid from the reservoir onto a surface of the eye. The device further includes a cooling element configured to cool the fluid from the reservoir such that it exits the nozzle at a temperature of between −100° C. and 15° C. The device further includes an ultrasonic vibrator positioned near the nozzle and configured to generate mist from at least part of the fluid.

A device and a method for cooling living tissues for a medical purpose and other purposes are proposed. The device may include a container configured to accommodate a cooling medium, the container including a plurality of divided members each having a contact surface which is thermally coupled with the cooling medium. The device may also include a cooling generator configured to provide cooling energy to the container, and disposed on another surface of the divided member other than the contact surface. The device may further include a lubricating member provided to the contact surface of the divided member, wherein the container is configured to be thermally coupled with the cooling medium via the lubricating member.

The invention provides a skin treatment device especially for use for treating skin in terms of cleaning, exfoliating and/or massaging the skin. The device comprising a housing and a skin treatment head releasably attached to the housing. The skin treatment head being rotatable around an axis element associated with the housing, wherein the housing encloses an actuator configured to rotate the skin treatment head, wherein the skin treatment head comprises one or more brushes associated with a support element, wherein the device further comprises a first thermally conductive element configured at a shortest distance (d1) to the one or more brushes selected from the range of 0-40 mm, and wherein the device further comprises a thermoelectric element configured to heat in a first mode the first thermally conductive element to provide a hot surface.

A device comprising a housing having a handle end and a treatment end. The treatment end is configured to provide an antimicrobial treatment and a heat treatment. The treatment end comprises an applicator having an applicator surface for providing at least the heat treatment. The device includes a heat generation unit configured to heat the applicator surface in use, a source of antimicrobial agent, and a control unit operatively connected to at least the heat generation unit for controlling the heat generation unit. The device can be a hand-held device and used to apply topical treatment to a treatment area of a subject.

A handheld cryoanesthesia or analgesia device for cooling a target area on cutaneous membranes, mucous membranes, and tissue of the mucocutaneous zone having an elongated body and a thermoelectric cooling system disposed within the elongated body. The thermoelectric cooling system is configured to physically contact and thermally couple the target area of the cutaneous membranes, mucous membranes, and tissue of the mucocutaneous zone to induce cryoanesthesia or analgesia. The thermoelectric cooling system includes a thermally-conductive cold tip, a thermally-conductive cooling power concentrator thermally coupled to the cold tip, at least one Peltier unit module thermally coupled to the cooling power concentrator, a heatsink thermally coupled to at least one Peltier unit module, a power source, at least one thermal sensor, and a controller operably outputting a control signal to the Peltier unit module to maintain a predetermined temperature.

A method in which a location is determined on the skin that is proximate to a sensory nerve that is associated with a painful condition. At least one needle of a cryogenic device is inserted into the location on the skin such that the needle is proximate to the sensory nerve. The device is activated such that the at least one needle creates a cooling zone about the sensory nerve, thereby eliminating or reducing severity of the painful condition.