Systems for treating a subject's tissue can include a thermally conductive cup, a sealing member, and/or a liner assembly. The systems can include an applicator capable of being reconfigured for a particular treatment site. Components of the applicator can be replaced to achieve a desired configuration. The replaceable components can include contoured heads, liners, and/or sensors. The applicator can draw a vacuum to install various components and/or draw tissue into the applicator. The applicator can cool and/or heat the tissue to affect targeted tissue.

The present disclosure includes devices, systems and related methods useable for controlling a patient's body temperature by endovascular heat exchange as well as body surface heat exchange.

Devices, systems and methods for controlling a patient's body temperature by endovascular heat exchange.

A temperature regulation system for regulating the temperature of a portion of a body, in particular of a user's body.

The system comprises one humidity sensor for measuring humidity in the vicinity of the portion of a body, one temperature adjustment element for providing heat to a portion of the body, a memory unit for storing one threshold humidity related value (H.sub.thresh) and one reference user information related values (t.sub.ref, θ.sub.ref), a controlling unit in communication with the humidity sensor, with the memory unit and with the temperature adjustment element, and configured to determine one instant user information related value (t.sub.inst, θ.sub.inst), perform a comparison between one instant user information related value (tin.sub.ct, θ.sub.inst) and one triggering user information related value (t.sub.trig, θ.sub.trig) based on said reference user information related value (t.sub.ref, θ.sub.ref), activate the temperature adjustment element to provide heat to a portion of the body depending on the result of said comparison.

The controlling unit is further configured to receive one instant humidity (H.sub.inst) measured in the vicinity of the portion of the body from the humidity sensor, perform a comparison between said instant humidity related value (H.sub.inst) and one triggering humidity related value (H.sub.trig) based on said threshold humidity related value (H.sub.thresh), and to set the one triggering user information related value (t.sub.trig, θ.sub.trig) to a value lower than said reference user information related value (t.sub.ref, θ.sub.ref) when the instant humidity related value (H.sub.inst) is greater or equal to said threshold humidity related value (H.sub.thresh).

An injection tool and associated methods are shown. Example tools and methods described provide cooling to numb a local area prior to an injection. The local numbing can be used to reduce or eliminate pain associated with the subsequent injection. In selected examples, circuitry and one or more sensors are used to calculate an appropriate contact time of a heat sink with the local region to best provide a desired amount of numbing.

A therapeutic treatment device, system and method for improving administration of a temperature sensitive drug into a tissue on the body of a patient at a drug injection site are disclosed. The device includes a treatment element with a controllable heating element in temperature communicative contact with the tissue adjacent to the drug injection site. The controllable heating element is configured to heat the tissue adjacent to the drug injection site to a controllable temperature but does not heat the injected drug above a predetermined limiting temperature, above which degradation of the injected drug may occur.

The present invention relates to a control and command method for a device for thermal stimulation of animal or human tissue (1), said method being characterised in that it includes: determining a neutral temperature applied to the tissue (1), thermally adjusting the neutral temperature by activating a control loop, determining a cold or hot thermal stimulation temperature to be applied to the tissue (1), in alternation with the neutral temperature; determining a duration and a frequency of the thermal stimulations; in the case of an instruction to initiate the stimulation temperature by activating a control loop and by deactivating the control loop on the neutral temperature; and synchronising a physiological recording with the thermal stimulation.

A medical cooling device and a method for operating the same are provided.

Disclosed herein is a system, apparatus and method directed to an expandable and conformable targeted temperature management (TTM) pad. The system, apparatus and method pertain to a medical pad for exchanging thermal energy between a TTM fluid and a patient. The pad includes an insulating layer, a fluid containing layer for containing the TTM fluid, and a patient contact surface. The fluid containing layer is configured for circulating the TTM fluid. The patient contact surface defines a first patient contact area to facilitate thermal energy exchange with the patient. One or more slits are arranged in at least the insulating layer of the pad to facilitate stretching the pad and conforming to a contour of a patient's anatomy. The stretching can expand the patient contact surface to a larger second patient contact area. The pad can further include a flexible fabric cover.

Devices, systems and methods for removing heat from subcutaneously disposed lipid-rich cells are disclosed. In selected embodiments, suction and/or heat removal sources are coupled to an applicator. The applicator includes a flexible portion and a rigid portion. The rigid portion includes a thermally conductive plate and a frame coupling the thermally conductive plate and the flexible portion. An interior cavity of the applicator is in fluid communication with the suction source, and the frame maintains contiguous engagement between the heat removal source and the thermally conductive plate.