This document describes implantable medical device systems and methods of using such devices for delivering therapy via temperature modulation. For example, this document describes medical device systems and related methods for the treatment of cardiac arrhythmias by delivering cooling to epicardial tissue. In some embodiments described herein, arrhythmias can be treated by an implantable system for painlessly terminating arrhythmias. The devices and methods provided herein permit prompt termination of atrial fibrillation almost immediately after an episode begins (to prevent persistence) and are effective irrespective of patient age and comorbidities.

Methods and apparatuses for manipulating the temperature of a surface are provided. Devices of the present disclosure may include a thermal adjustment apparatus, such as a controller in electrical communication with one or more thermoelectric materials, placed adjacent to the surface of skin. The device may generate a series of thermal pulses at the surface, for providing an enhanced thermal sensation for a user. The thermal pulses may be characterized by temperature reversibility, where each pulse includes an initial temperature adjustment, followed by a return temperature adjustment, over a short period of time (e.g., less than 120 seconds). The average rate of temperature change upon initiation and upon return may be between about 0.1° C./sec and about 10.0° C./sec. In some cases, the average rate of the initial temperature adjustment is greater in magnitude than the average rate of the return temperature adjustment.

The invention relates to a device for hyperthermic treatment of itching, for example following insect bites, wherein during the treatment a treatment surface is regulated at a temperature of preferably between 42° C. and 56° C. for a period of 2 sec to 12 sec and a hardware-implemented temperature monitor limits the maximum temperature of the treatment surface and a safety fuse shuts off the device in the case of a short-circuit or uncontrolled continuous heating.

A portable heating apparatus includes a top layer and a bottom layer connected to the top layer to form a cavity. An electric heating element is disposed within the cavity, and a temperature-retaining component, such as a gel layer, is affixed within the cavity adjacent to the electric heating element and adjacent to the top layer. A power cord is in electrical communication with the electric heating element and connectable to a power source to provide power to the electric heating element, the power cord detachable from the portable heating apparatus. The temperature-retaining component is capable of retaining heat generated by the electric heating element and creating a generally uniform distribution of heat across the top layer.

Various systems and devices are provided for determining a weaning readiness for weaning a patient from a thermoregulated microenvironment. In one example, a method includes receiving current patient parameters of the patient and applying a weaning model to the current patient parameters to calculate a weaning index representing a likelihood that the patient can be successfully weaned from the microenvironment. The method also includes outputting the weaning index for display on a display device or for storage in a medical record of the patient and upon outputting the weaning index, receiving one or more subsequent patient outcomes, the one or more subsequent patient outcomes comprising whether the patient developed any complications within the duration since being weaned from the microenvironment. The method also includes updating the weaning model based on the one or more received subsequent patient outcomes.

Devices, systems and methods for controlling a patient's body temperature by endovascular heat exchange.

Systems, devices, and methods for neurostimulation via vestibular stimulation are described. One example is a device for administering thermal stimulation to an ear canal of a subject. The device may include an earpiece configured to be at least partially insertable into the ear canal of the subject; a thermoelectric device thermally coupled to the earpiece and configured to heat and/or cool the earpiece to thereby heat and/or cool the ear canal of the subject; and a controller configured to administer a selected treatment plan including administering a caloric vestibular stimulation (CVS) stimulus to the ear canal of the subject in a condition-treatment effective amount during a first treatment interval. The treatment plan may be effective to produce a durable improvement in at least one symptom of the condition for a time of at least 1 week following cessation of the administering.

Various implementations include wearable devices and methods for managing respiration and user health. In some particular implementations, a wearable device includes: a mount sized to couple with a body part of a user; and a housing coupled with the mount. The housing at least partially contains: a contact element for applying pressure to the body part; and an actuator coupled with the contact element, the actuator configured to actuate the contact element in applying pressure to the body part according to a prescribed pattern. The prescribed pattern includes at least two repetitions, each repetition having: a first segment at a progressively increasing pressure; a second segment at a substantially constant pressure, following the first segment; a third segment at a progressively decreasing pressure, following the second segment; and a fourth segment at a substantially constant pressure that is less than the substantially constant pressure of the second segment.

A cooling device for removing heat from subcutaneous lipid-rich cells of a subject having skin is provided. The cooling device includes a plurality of cooling elements movable relative to each other to conform to the contour's of the subject's skin. The cooling elements have a plurality of controllable thermoelectric coolers. The cooling elements can be controlled to provide a time-varying cooling profile in a predetermined sequence, can be controlled to provide a spatial cooling profile in a selected pattern, or can be adjusted to maintain constant process parameters, or can be controlled to provide a combination thereof.

Devices, systems and methods for removing heat from subcutaneously disposed lipid-rich cells are disclosed. In selected embodiments, suction and/or heat removal sources are coupled to an applicator. The applicator includes a flexible portion and a rigid portion. The rigid portion includes a thermally conductive plate and a frame coupling the thermally conductive plate and the flexible portion. An interior cavity of the applicator is in fluid communication with the suction source, and the frame maintains contiguous engagement between the heat removal source and the thermally conductive plate.