Disclosed herein is a compression apparatus useful in treating pain, inflammation, or other conditions of a joint and joint area through use of compression and optionally temperature control. The compression apparatus is configured for physical and functional flexibility in that the apparatus is flexible and can be worn over or under clothing. The compression apparatus is generally suited for support of an ankle joint, a knee joint, a wrist joint, shoulder joint, elbow joint or hip joint depending on size, shape and securement configurations. In one embodiment, the compression apparatus comprises at least one flexible compression member and at least one securement means configured for adjustably providing compression to the joint area of a wearer. In certain embodiments, an apparatus of the present disclosure may comprise temperature-control means, decorative features, devices for visual display of treatment information such as elevation and temperature, as well as other information useful in treatment.

Disclosed herein is a compression apparatus useful in treating pain, inflammation, or other conditions of a joint and joint area through use of compression and optionally temperature control. The compression apparatus is configured for physical and functional flexibility in that the apparatus is flexible and can be worn over or under clothing. The compression apparatus is generally suited for support of an ankle joint, a knee joint, a wrist joint, shoulder joint, elbow joint or hip joint depending on size, shape and securement configurations. In one embodiment, the compression apparatus comprises at least one flexible compression member and at least one securement means configured for adjustably providing compression to the joint area of a wearer. In certain embodiments, an apparatus of the present disclosure may comprise temperature-control means, decorative features, devices for visual display of treatment information such as elevation and temperature, as well as other information useful in treatment.

We report a method of treating an epileptic seizure in a patient, comprising: detecting said epileptic seizure, based on body data from said patient; and reducing a flow of blood to a brain of said patient in response to said detected seizure; wherein said reducing is effected by: increasing the parasympathetic input to said patient's heart, such as by electrically stimulating a parasympathetic nervous structure, applying cooling energy to a sympathetic nervous structure, or administering a cholinergic or a sympatho-blocking agent to said patient. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.

This cooling apparatus includes a tube (10) having an opening portion (10a) in one end portion in a longitudinal direction thereof, a cap (30) capable of opening/closing the opening portion (10a), a non-freezing drinkable coolant (20) that fills the tube (10), and a container (50) that contains the tube (10) filled with the coolant (20). The tube has a constricted portion (10d) having a reduced inner diameter.

A system and method of monitoring, controlling and/or detecting events during the removal of heat from subcutaneous lipid-rich tissue is described. In some examples, the system detects an increase in temperature at a treatment device in contact with the skin of a subject, determines that the increase in temperature is related to a treatment event, and performs an action based on the determination. In some examples, the system shuts off the treatment device, alerts an operator, or reduces the cooling in response to a determined treatment event.

A system and method of monitoring, controlling and/or detecting events during the removal of heat from subcutaneous lipid-rich tissue is described. In some examples, the system detects an increase in temperature at a treatment device in contact with the skin of a subject, determines that the increase in temperature is related to a treatment event, and performs an action based on the determination. In some examples, the system shuts off the treatment device, alerts an operator, or reduces the cooling in response to a determined treatment event.

Provided herein are systems, compositions, and methods for improving one or more skin characteristics in a subject. These systems, compositions, and methods are configured to cool the subject's skin at a target site to a degree that alters adipocyte signaling but does not produce significant destruction of subcutaneous lipid-rich cells. In some embodiments, alteration of adipocyte signaling produces an improvement in one or more skin characteristics.

A method for anesthetizing a human patient undergoing surgery and/or pain block procedure, the method comprising sterilizing the patient's skin including a target region, the target region including a surgical site including the patient's spine; inserting at least one cryo-needle into a first tissue region, the cryo-needle having a distal end configured to cool surrounding patient tissue, the first tissue region comprising soft tissue superficial to the one or more vertebra and on a first lateral side of the patients spine; cooling the distal end of the cryo-needle to cause cooling of surrounding patient tissue thus inhibiting one or more sensory nerves in the surrounding patient tissue; thereafter, performing spinal surgery on the patient's spine at the surgical site; and, thereafter, performing an erector spinae plane block to further inhibit nerves post-operatively in the target region.

Methods are provided herein for affecting a region of a subject's body, comprising exposing the region to a cooling element under conditions effective to cool subcutaneous adipose tissue in said region; and increasing the blood flow rate to the cooled tissue by exposing the tissue to an energy source. Methods are also provided for treating subcutaneous adipose tissue in a region of a subject's body, comprising exposing said region to a cooling element under conditions effective to cool said tissue; and exposing the tissue to an energy source to increase the blood flow rate to the cooled tissue, thereby stimulating reperfusion in, and/or causing an ischemia-reperfusion injury to, the cooled tissue.

Methods are provided herein for affecting a region of a subject's body, comprising exposing the region to a cooling element under conditions effective to cool subcutaneous adipose tissue in said region; and increasing the blood flow rate to the cooled tissue by exposing the tissue to an energy source. Methods are also provided for treating subcutaneous adipose tissue in a region of a subject's body, comprising exposing said region to a cooling element under conditions effective to cool said tissue; and exposing the tissue to an energy source to increase the blood flow rate to the cooled tissue, thereby stimulating reperfusion in, and/or causing an ischemia-reperfusion injury to, the cooled tissue.