A clinical grid electrode system for seizure control through local cooling, mapping brain function and me provision of reversible functional ablation. The system includes a modular, scalable, cooling and sensing array composed of a plurality of cooling sensing elements. The system also includes a control system to which die cooling and sensing array is coupled for providing for control and monitoring of die cooling sensing elements making up the cooling and sensing array.

A clinical grid electrode system for seizure control through local cooling, mapping brain function and me provision of reversible functional ablation. The system includes a modular, scalable, cooling and sensing array composed of a plurality of cooling sensing elements. The system also includes a control system to which die cooling and sensing array is coupled for providing for control and monitoring of die cooling sensing elements making up the cooling and sensing array.

A method and apparatus for manipulating a temperature set-point of a human or homeothermic-animal for increasing or decreasing the body temperature above or below the prevailing body temperature for therapeutic purposes. The method includes the steps of warming or cooling sphenoid sinuses externally resulting in manipulation of the temperature of the pituitary gland which in turn results in manipulation of the body-temperature set-point and the body temperature manipulates accordingly to the new temperature set-point. A heat exchange medium can be used to warm or cool sphenoid sinuses and thus the pituitary gland. The heat exchange fluid can be liquid, or gas maintained at a predetermined temperature. Alternatively, a temperature-controlled probe can be used that upon contact with the sphenoid sinuses provides for the heat exchange.

A method and apparatus for manipulating a temperature set-point of a human or homeothermic-animal for increasing or decreasing the body temperature above or below the prevailing body temperature for therapeutic purposes. The method includes the steps of warming or cooling sphenoid sinuses externally resulting in manipulation of the temperature of the pituitary gland which in turn results in manipulation of the body-temperature set-point and the body temperature manipulates accordingly to the new temperature set-point. A heat exchange medium can be used to warm or cool sphenoid sinuses and thus the pituitary gland. The heat exchange fluid can be liquid, or gas maintained at a predetermined temperature. Alternatively, a temperature-controlled probe can be used that upon contact with the sphenoid sinuses provides for the heat exchange.

Home-use applicators for non-invasively removing heat from subcutaneous, lipid-rich cells via phase change coolants, and associated devices, systems and methods. A device in accordance with a particular embodiment includes an applicator releasably positionable in thermal communication with human skin, and a coolant vessel having a coolant. The device further includes a heat transfer conduit operatively coupled to the applicator and housing a heat transfer fluid that is isolated from fluid contact with the coolant. A heat exchanger is operatively coupled between the coolant vessel and the heat transfer conduit to transfer heat between the heat transfer fluid and the coolant, and a fluid driver is operatively coupled to the heat transfer conduit to direct the heat transfer fluid between the applicator and the heat exchanger.

The present invention provides a device for diagnosing and treating ocular deviation, comprising: an eye mask which is worn by an examinee, and in which an eye movement capturing means for capturing the eye movement of the examinee is provided; a temperature-regulating pipe which is inserted into the ear of the examinee and which increases or decreases the temperature inside the ear of the examinee; a heat source supply part for supplying a heat source to the temperature-regulating pipe from the outside in order to increase and decrease the temperature of the temperature-regulating pipe; a fixing main body which is worn by the examinee, and which has a mounting hole, in which the temperature-regulating pipe is mounted, in order to fix the temperature-regulating pipe inserted into the ear of the examinee; and a control part, which is connected to the eye movement capturing means and the heat source supply part, receives an image of the eye captured by the eye movement capturing means, and extracts center coordinates from the transmitted image of the eye to compare same with the center coordinates of the eye inputted in advance, and then operates the heat source supply part to control the temperature of the temperature-regulating pipe in order to move the eye to the center coordinates of the eye inputted in advance.

The present invention provides a device for diagnosing and treating ocular deviation, comprising: an eye mask which is worn by an examinee, and in which an eye movement capturing means for capturing the eye movement of the examinee is provided; a temperature-regulating pipe which is inserted into the ear of the examinee and which increases or decreases the temperature inside the ear of the examinee; a heat source supply part for supplying a heat source to the temperature-regulating pipe from the outside in order to increase and decrease the temperature of the temperature-regulating pipe; a fixing main body which is worn by the examinee, and which has a mounting hole, in which the temperature-regulating pipe is mounted, in order to fix the temperature-regulating pipe inserted into the ear of the examinee; and a control part, which is connected to the eye movement capturing means and the heat source supply part, receives an image of the eye captured by the eye movement capturing means, and extracts center coordinates from the transmitted image of the eye to compare same with the center coordinates of the eye inputted in advance, and then operates the heat source supply part to control the temperature of the temperature-regulating pipe in order to move the eye to the center coordinates of the eye inputted in advance.

Systems, methods and devices for utilizing heat transfer parameters or energy expenditure of devices providing controlled hypothermia, normothermia or hyperthermia to detect changes, or the absence of changes, a patient's endogenous set-point temperature; which is not available during exogenously induced targeted temperature management. A particular embodiment would allow detection of fever in patients undergoing targeted temperature managed.

The invention is directed to a mouth piece for cooling of oral tissue of a patient during chemotherapy treatment. The mouth piece includes a cooling medium contained within the top element and the bottom element and able to retain a cooling environment within the mouth sufficient to reduce capillary blood flow to the patient's mouth. In one embodiment, an external chamber extends from the front of the mouth piece to house a cooling medium. The external chamber can be configured so that it is removably attached to the mouth piece. A support device can be utilized to support the external chamber during use.

The invention is directed to a mouth piece for cooling of oral tissue of a patient during chemotherapy treatment. The mouth piece includes a cooling medium contained within the top element and the bottom element and able to retain a cooling environment within the mouth sufficient to reduce capillary blood flow to the patient's mouth. In one embodiment, an external chamber extends from the front of the mouth piece to house a cooling medium. The external chamber can be configured so that it is removably attached to the mouth piece. A support device can be utilized to support the external chamber during use.