Injection device comprising an elongated body (1) with a hollow needle (8) at a distal end; a reservoir for an injection material to be delivered through the needle; a plunger (3) with a first force element (5) configured to provide an injection force to said injection material, and a distal element (10) attached to the distal end of the device thereby sealing a needle lumen, wherein the distal element comprises a tissue interface and a distal seal (11), and wherein the distal seal is penetrable by a distal tip of the needle by the application of pressure on a tissue surface with the distal end of the device, wherein the penetrated distal element becomes slidable on the needle to allow advancement of the needle into tissue, wherein the penetrated distal seal opens a path for flow or delivery of the injection material from the distal end of the needle.

Various embodiments of the present disclosure provide a liquid medication dispensing apparatus. The apparatus includes a housing including an inner cavity and a cap operable between an open position and a closed position. A cartridge assembly is configured to be inserted in the inner cavity. The cartridge assembly includes a support structure, a mounting platform, a nozzle base including a nozzle, and an intermediate body portion coupling the support structure and the nozzle base while maintaining a gap therebetween. The apparatus includes a control unit disposed in the housing. The control unit is configured to receive a first signal from a circuitry associated with a dispensing button, upon detection of an input on the dispensing button. Upon receipt of the first signal, the control unit provides a command signal to a drive mechanism for retrieving a liquid medication from a medication bottle and extrude the liquid medication through the nozzle.

Systems and methods for removing a preservative from a solution, emulsion, or suspension comprising an ophthalmic agent are described herein. Said systems comprise a preservative-removing polymeric matrix comprising an active matrix component and an inactive matrix component. A method for administering an ophthalmic agent comprises providing a solution, emulsion, or suspension comprising an ophthalmic agent, and a preservative; and providing a preservative-removing polymeric matrix comprising an active matrix component and an inactive matrix component, and wherein the polymeric matrix is configured to selectively absorb the preservative when the solution, emulsion, or suspension is passed therethrough.

Multi-dose preservative-free ocular fluid delivery devices are provided. The fluid delivery device includes a fluid dispensing system and a fluid package for storing a liquid therein and supplying said liquid to the dispensing system. The dispensing system comprises an elongated chamber which includes a check valve which defines a frontal closure to the chamber. The valve is normally closed and hermetically seals the chamber. The dispenser includes a vibration motor that induces oscillations to the chamber and to the fluid within. The oscillations of the chamber impart momentum to the fluid stored in the chamber which in turn imparts force that cyclically opens the valve to dispense streams or liquid droplets. Fluid is dispensed only when the motor oscillates while otherwise the valve is hermetically closed.

A liquid dispensing device includes a dispensing end piece and a neck of a reservoir for storing the liquid, the end piece being attached to the neck, which has a tubular internal surface. The end piece has a tubular internal skirt that is mounted in the neck and defines, with the internal surface, at least one annular sealing zone, preventing the liquid from passing between the internal skirt and the neck. The skirt defines, with the internal surface, a separate zone for retaining shavings, which prevents shavings that are formed in the sealing zone while the end piece is being fitted into the neck from getting into the reservoir.

A device has a first part with a valve seat and storage chamber, and a second part with a flexible valve cover and actuator. The storage chamber may be formed from a pre-form blow-molded into a flexible pouch defining a variable-volume storage chamber. The flexible valve cover and valve seat form a normally closed valve seam therebetween. The valve cover is movable in response to fluid at an inlet to the seam exceeding a valve opening pressure of the one-way valve between (i) a normally closed position with valve cover and valve seat in contact with each other and defining the normally closed seam, and (ii) a second position with at least a portion of the valve cover spaced away from the valve seat to allow the fluid to pass through the seam. The one-way valve may have anti-spritz features for using the device to dispense a substance, such as to the eye. The device may contain prostaglandins without the device material absorbing the prostaglandins material and/or without the material being adsorbed into the drug.

An injection tool and associated methods are shown. Example tools and methods described provide cooling to numb a local area prior to an injection. The local numbing can be used to reduce or eliminate pain associated with the subsequent injection. In selected examples, circuitry and one or more sensors are used to calculate an appropriate contact time of a heat sink with the local region to best provide a desired amount of numbing.

An eyedropper is provided for administering a predetermined volume of liquid onto the surface of an eye. The eyedropper includes a body having a nozzle in fluid communication with the internal cavity of the reservoir body. Projecting from an inner surface of the reservoir body are a first projecting portion having a first contact surface and a second projecting portion having a second contact surface. The first contact surface and the second contact surface are disposed opposite from one another and are spaced apart from one another. In use, the first and second contact surfaces limit the displacement volume of the internal cavity when the eyedropper is squeezed thereby limiting the volume of liquid expelled from the nozzle.

A BAK removal device is constructed as a plug of microparticles of a hydrophilic polymeric gel that displays a hydraulic permeability greater than 0.01 Da. The polymer hydrophilic polymeric gel comprises poly(2-hydroxyethyl methacrylate) (pHEMA). The particles are 2 to 100 μm and the plug has a surface area of 30 mm.sup.2 to 2 mm.sup.2 and a length of 2 mm to 25 mm and wherein the microparticles of a hydrophilic polymeric gel has a pore radius of 3 to 60 μm.

An apparatus includes a first tray member, a second tray member, and a lid. The first tray member has a first portion and a second portion. The first portion defines a first volume, and the second portion defines a second volume configured to receive a medicament container. The second tray member defines a third volume having a sidewall including a retention portion configured to retain an ocular injector within the third volume. The second tray member is coupled within first volume such that the sidewall of the second tray member and a sidewall of the first tray member enclose the ocular injector. The lid is coupled to the first tray member about the first volume, and is constructed from a material formulated to maintain sterility of the first volume.