Disclosed in some forms is a process of limiting the impact of surgery on a nerve, the process comprising applying a therapeutic substance to the nerve during surgery. In some aspects, disclosed is a formulation for reducing nerve trauma comprising an active pharmacological ingredient adapted to intervene in the activation of pathways of cellular degradation within the nerve and a carrier adapted to reduce dissemination of the active pharmacological ingredient beyond the site at which its effect is intended.

A delivery tool connectable with a syringe can be used to deliver a viscoelastic solution. The tool includes a first segment, a second segment and an inner lumen defined by the first and second segments. A distal portion extends from the second segment in a curved manner.

An apparatus includes a body, a needle, a catheter, and an actuator assembly. The needle extends distally from the body. The needle has an inner wall defining a needle lumen. The needle lumen is in fluid communication with a fluid port of the body. The catheter is slidably disposed in the needle lumen. The catheter has a catheter lumen. The first actuator assembly is configured to translate the catheter within and relative to the needle. The apparatus may also include an actuator assembly that is configured to rotate the needle relative to the body. The apparatus may be used to first deliver a leading bleb of fluid to the subretinal space in a patient's eye via the needle. The apparatus may then be used to deliver a therapeutic agent to the subretinal space in the patient's eye via the catheter.

Disclosed are devices and methods for delivering a sheet of tissue into the eye in such a way that damage to the tissue is minimized, damage to the eye during insertion and manipulation of the tissue is minimized, and the tissue is released and delivered in a precise and controlled fashion.

A hand-held aspiration device is provided which has a relatively small suction volume along a suction path to improve responsiveness of the aspiration device when the device is activated. The device may be manually powered and may be provided without electronic controls. The device has a suction path which may be purged into a disposal enclosure to reduce the volume of material under the influence of the suction pressure during the procedure. The suction source may also be part of the hand-held unit to further reduce the suction path and suction volume.

An inserter device is provided for use with a glaucoma drainage device including a tube having a proximal end and a distal end with a lumen extending from the proximal end to the distal end. The inserter device includes an elongate member having a distal end defining a stop surface, and a stylus extending beyond the distal end of the elongate member. The stylus is sized and configured to be received within the lumen of the glaucoma drainage device with the stop surface interfacing to and limiting proximal movement of the glaucoma drainage device. The stylus has a first length that extends beyond the stop surface that is less than a second length of a portion of the lumen of the tube of the glaucoma drainage device that extends beyond the stop surface. Systems and methods are also described and claimed.

A fluid dispensing device includes a cartridge comprising a housing and a head coupled to the housing. The housing forms a first chamber configured to accommodate a fluid; and the head includes a nozzle; and an elastomeric wall that is spaced from the nozzle to form a holding chamber. The holding chamber is in fluid communication with the first chamber and configured to accommodate a portion of the fluid; and the nozzle forms one or more openings to eject the portion of the fluid from the holding chamber. The one or more openings form an oblong shape such that a length of the oblong shape is greater than a width of the oblong shape. The one or more openings can include two parallel slots that together form the oblong shape.

The present disclosure provides methods and devices for delivering pilocarpine to the eye. In certain aspects, the disclosure provides method for delivering a composition comprising pilocarpine to an eye of a subject in need thereof as a micro-dose stream of droplets. In certain embodiments, the method treats or alleviates one or more symptoms of presbyopia, in particular presbyopia in adults 40 years of age or older, in the subject in need thereof. In certain embodiments, the present disclosure utilizes relatively high concentrations of pilocarpine in the solution to be administered and as a single active agent.

A balm mixture is provided for treating dry eyes. The balm mixture is applied from a container to the skin of the user adjacent their lower eyelid. The balm mixture includes a carrier portion and an active ingredient portion which will cause tears to form in the eye of a user adjacent the application thereof, thereby alleviating a dry eye condition.

The present disclosure is directed to compositions comprising oxymetazoline and methods of stabilizing oxymetazoline compositions for long term storage.