The present invention relates to a drug delivery system comprising a core and a shell in which the core comprises a hydrolytically degradable polymer X which polymer backbone comprises pendant ester and acid functionalities and in which the shell comprises a hydrolytic degradable polymer Y. The hydrolytic degradable polymers X and Y are different polymers. Polymer X further comprises amino-acids in the polymer backbone and degrades via zero order degradation kinetics for a period of at least 3 months. Polymer Y degrades via auto-acceleration degradation kinetics.

A meniscus compensating device for a low dosage fluid dispenser, the dispenser having a pump that is fluidly connectable between a pump outlet and a nozzle portion of the dispenser. The pump is operable to dispense a predetermined dose of the fluid through the pump outlet toward the nozzle portion. The meniscus compensating device has a fluid displacer, operable to displace a predetermined volume provided within the fluid column defined between the pump outlet and the nozzle mouth of the nozzle portion and the fluid displacer displaces the predetermined volume during dispensation of a releasing dose from the dispenser pump. The fluid displacer is at least partially released as or after the pump outlet is closed following the dose dispensation, thereby enabling the fluid column defined between the pump outlet and the nozzle mouth of the nozzle portion to occupy the previous displaced predetermined volume, thereby causing the meniscus formed after the dose dispensation at the terminal end of the fluid column at or near the nozzle mouth to come to rest at a substantively consistent predetermined position at or within the nozzle mouth.

An apparatus includes a body and a pair of rigid legs extending from the body. The body includes an engagement feature configured to engage a deployment instrument. The legs are parallel with each other. Each leg has a sharp tip. The legs both extend along a plane. The body defines a guide opening. The guide opening is oriented transversely relative to the plane associated with the legs. The guide opening is sized to receive a cannula having a generally flat profile. The guide opening is configured to guide the cannula through a sclerotomy at a substantially tangential orientation.

An apparatus includes a pad assembly, an injector assembly, an injector driver, and a fluid source. The pad assembly is sized and configured to be placed on a forehead of a patient. The injector assembly includes a body, a flexible cannula, and a needle. The body is configured to be removably secured to the pad assembly. The cannula is sized to be inserted through an incision in an eye of a patient. The needle is slidably disposed in the cannula. The injector driver is operable to drive the needle longitudinally relative to the flexible cannula. The fluid source assembly is in fluid communication with the needle.

An apparatus includes an injector, a first fluid conduit, a second fluid line, and a control module. The injector includes a body, a flexible cannula, a flexible needle, and a sensor. The needle is configured to translate relative to the cannula. The sensor is operable to detect a position of the needle relative to the cannula. The first and second fluid lines are coupled with the needle. The control module is in communication with the sensor, with the first fluid conduit, and with the second fluid conduit. The control module is configured to provide delivery of a first fluid through the first conduit to the needle based on a signal from the sensor. The control module is further configured to provide delivery of a second fluid through the second conduit to the needle.

A handheld cryoanesthesia or analgesia device for cooling a target area on cutaneous membranes, mucous membranes, and tissue of the mucocutaneous zone having an elongated body and a thermoelectric cooling system disposed within the elongated body. The thermoelectric cooling system is configured to physically contact and thermally couple the target area of the cutaneous membranes, mucous membranes, and tissue of the mucocutaneous zone to induce cryoanesthesia or analgesia. The thermoelectric cooling system includes a thermally-conductive cold tip, a thermally-conductive cooling power concentrator thermally coupled to the cold tip, at least one Peltier unit module thermally coupled to the cooling power concentrator, a heatsink thermally coupled to at least one Peltier unit module, a power source, at least one thermal sensor, and a controller operably outputting a control signal to the Peltier unit module to maintain a predetermined temperature.

Apparatuses, systems, and methods for producing a lens surface through electrowetting. The lens surface may be used in an ophthalmic lens such as an intraocular lens, contact lens, or eyeglass lens. A fluid chamber may include a conductive fluid and a curable fluid positioned therein. An electrode maybe used to vary a shape of a surface of the curable fluid through electrowetting. The surface of the curable fluid may be cured to produce a lens surface.

A combined intraocular pressure (IOP) measuring and eye medication dispensing device may include a first micro-electro-mechanical-system (MEMS) sensor to generate IOP measurements of a living organism's eye; a medication dispensing device to dispense medication into the living organism's eye; a second MEMS micro-dispenser to interface with the medication dispensing device and to control the dispensing of the medication into the living organism's eye; and an analog-to-digital (A-to-D) converter to receive control signals. The A-to-D converter may communicate the control signals to the first MEMS sensor or the second MEMS micro-dispenser; receive the generated IOP measurements from the first MEMS sensor; receive medication dispensing parameters from the second MEMS micro-dispenser or medication dispensing device, and communicate the generated IOP measurements or the medication dispensing parameters. The device may also include a communications interface to receive the control signals from one or more processors in an external control module.

This disclosure relates to a cap assembly for a medicament delivery device that has a cap body arranged to be connected to a medicament delivery device for protecting and for removing a medicament delivery member shield. The cap body has an inner cap structure defining a channel extending along the central axis of the cap body, and a gripping member configured to be received in the channel with a friction fit and to receive a medicament delivery member shield. The gripping member has a first leg, a second leg, and a transverse portion extending between the first leg and the second leg, which transverse portion defines the leading edge of the gripping member when received by the channel.

An eye drop applicator includes an applicator body with a top cavity, a bottom cavity, and a dispensing channel connecting the bottom cavity with the top cavity such that a fluid can selectively flow through the dispensing channel to the top cavity. The top cavity includes an opening at a top end of the applicator body, and the bottom cavity includes a bottom opening at a bottom end of the applicator body. The bottom cavity may receive a portion of an applicator container within the bottom cavity to assemble the eye drop applicator with the applicator container containing the fluid to be dispensed.