Disclosed herein is a method of alleviating symptoms of ocular surface discomfort, the method comprising: topically applying a cold slurry adjacent to a corneal limbus of an eye of a patient, wherein the cold slurry comprises water and a freezing point depressant, wherein the topical application of the cold slurry is configured to cause a degree of numbing of a cornea of the eye for a period of time, and wherein an ocular sensation of the eye is restored following the period of time.

An opto-mechanical system for operation with a container containing a fluid to be administered in an eye or a container such as a syringe for example to administer an insulin injection. The mount of the system is equipped with an optical system and a processing/recording means configured to receive optical data, from light (visual or infra-red) reflected by an area in the vicinity of the eye, which data represents temporal and spatial characteristics of a process of administering drops of the fluid from the container into the eye. Image analysis software or human observation may be used to analyze the recorded images.

An ophthalmic composition comprising Indigo Carmine, or Indigo Carmine and Trypan Blue, for identification of intraocular structures and membranes within the eye, and methods of delivering and using the same, for surgical treatments of the eye, including glaucoma and cataract surgery.

The present invention features the use of compstatin and complement inhibiting analogs thereof for treating and/or preventing age related macular degeneration and other conditions involving macular degeneration, choroidal neovascularization, and/or retinal neovascularization. The invention also provides compositions comprising compstatin or a complement inhibiting analog thereof and a second therapeutic agent. The invention also provides compositions comprising compstatin or a complement inhibiting analog thereof and a gel-forming material, e.g., soluble collagen, and methods of administering the compositions.

Systems, devices, and methods for replacing an eyedropper tip on an eyedropper bottle with a replacement eyedropper tip. Such a system may include, without limitation, a removal tool, an application tool, and a replacement eyedropper tip. The removal tool may be used to remove a preexisting eyedropper tip on an eyedropper bottle, and the application tool may be used to apply the replacement eyedropper tip to the eyedropper bottle. In some embodiments, the replacement eyedropper tip and the application tool may be formed as a single unit or effectively be the same component.

Multi-dose ocular fluid delivery devices are provided. Aspects of the fluid delivery devices include a fluid package and an actuator. The fluid package includes a reservoir of an ophthalmic formulation, an aperture and a valve member for sealing the aperture when fluid is not being ejected therethrough. The actuator is configured to operate the valve member so as to at least reduce, if not prevent, ingress of outside materials or contaminants into the reservoir, such that the ophthalmic formulation present in the reservoir does not require a preservative (e.g., where a preservative-free ophthalmic formulation is present in the reservoir). Also provided are methods of using the devices in fluid delivery applications, as well as a kit that includes components of the devices.

An ocular drainage system is provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the system includes an implantable device and an external control unit, the implantable device includes a non-invasively adjustable valve featuring at least one deformable tube and a disk rotatably mounted within a housing, such that rotation of the disk using the external control unit causes the disk to apply a selected amount of compression to the deformable tube, thereby adjusting the fluidic resistance of the deformable tube and regulating the intraocular pressure.

Dispenser for dispensing pharmaceutical liquid having a housing, a liquid reservoir arranged within the housing, an exit opening through which liquid is discharged into a surrounding atmosphere, an outlet channel connecting the liquid reservoir to the exit opening and having an outlet valve, openable in a pressure-dependent manner or actuatable manually, arranged in the outlet channel. With the valve closed, the outlet channel is subdivided into a first portion upstream of the outlet valve and a second portion downstream of the outlet valve. The housing is of antibacterial design in the region of surfaces which are intended to come into contact with the liquid, wherein it is exclusively surfaces in the region of the second portion and/or of an outer surface of the housing which have this antibacterial design.

The present invention is directed to compositions comprising semifluorinated compounds and their use as medicaments for topical administration to the eye.

Described here are systems and methods for accessing Schlemm's canal, for delivering a fluid composition therein, and for tearing the trabecular meshwork. The fluid composition may be a viscoelastic fluid that is delivered into the canal to facilitate drainage of aqueous humor by disrupting the canal and surrounding trabeculocanalicular tissues. The systems described here may be configured to cut or tear the trabecular meshwork with the body of an elongate member located within Schlemm's canal.