Device comprising polyurethane material for indicating pH at a locus, preferably as indication of presence of microbes, comprising a polyurethane network having immobilised therein one or more hydrophilic copolymers, the or each said copolymer comprising:

hydrophilic monomer; and
indicator monomer, which provides an indication in response to a change in hydrophilic state of said hydrophilic monomer and/or copolymer;
characterised in that the or each copolymer further comprises one or a plurality of ionisable groups or moieties or polymerisable monomers having one or more characteristic pKa values in the range 5 to 10 and which are responsive to pH at the locus in the range pH 5 to pH 10
and in that hydrophilic state of hydrophilic copolymer is dependent on ionisation of said ionisable groups, moieties or monomers; kit and device comprising the material and process for preparation thereof; and use in detecting or sensing microbes or pH.

The present invention is directed to a hemostatic textile, comprising: a material comprising a combination of glass fibers and one or more secondary fibers selected from the group consisting of silk fibers; ceramic fibers; raw or regenerated bamboo fibers; cotton fibers; rayon fibers; linen fibers; ramie fibers; jute fibers; sisal fibers; flax fibers; soybean fibers; corn fibers; hemp fibers; lyocel fibers; wool; lactide and/or glycolide polymers; lactide/glycolide copolymers; silicate fibers; polyimide fibers; feldspar fibers; zeolite fibers, zeolite-containing fibers, acetate fibers; and combinations thereof; the hemostatic textile capable of activating hemostatic systems in the body when applied to a wound. Additional cofactors such as thrombin and hemostatic agents such as RL platelets, RL blood cells; fibrin, fibrinogen, and combinations thereof may also be incorporated into the textile. The invention is also directed to methods of producing the textile, and methods of using the textile to stop bleeding.

The invention relates to a bandage (100) for enclosing a leg region or arm region of a living being, said bandage comprising: an elongate, tubular bandage part (10), at least part of which has a single slit in the longitudinal direction (LR) and which is designed to elastically enclose the leg or arm region when worn; and a closure part (20) which has closure elements (22) and which is fixedly connected to one end of the slit region (B) of the bandage part in order to detachably seal the slit region (B) by connecting the adjacent ends of the slit region (B) in an overlapping manner by means of the closure elements (22, 22). According to the invention, the bandage part (10) has different compression zones (K1, K2) in the longitudinal direction (LR) which each have different radial compression strengths transverse to the longitudinal direction (L).

A would dressing includes an absorbent core including a top carrier layer and a bottom carrier layer, a superabsorbent substance dispersed between the top carrier layer and the bottom carrier layer and the bottom carrier layer, and a shell formed by a facing layer and a backing layer. The absorbent core is located in the shell between the facing layer and the backing layer. The facing layer and the backing layer each can include a supporting structure. The supporting structure of the facing layer and the supporting structure of the backing layer each can include an inner surface facing towards the absorbent core and an outer surface facing away from the absorbent core. The outer surface of the supporting structure of the facing layer and/or the outer surface of the supporting structure of the backing layer can be laminated with a foam layer.

A method of forming a fibrin hydrogel composition is described. The method comprises forming an aqueous solution comprising fibrinogen, fibrin-forming enzyme, and a fibrin hydrogel forming salt. The fibrin hydrogel forming salt concentration is greater than or equal to the threshold concentration to form a fibrin hydrogel. The method further comprises reducing the salt concentration below the threshold concentration to form a fibrin hydrogel. In some embodiments, the aqueous solution further comprises a plasticizer. A fibrin composition is also described comprising a fibrin hydrogel having a fibrin concentration ranging from 0.1 to 10 wt-%; and a fibrin hydrogel forming salt. The fibrin hydrogel forming salt has a concentration less than a threshold concentration to form the fibrin hydrogel. The fibrin hydrogel or dehydrated fibrin hydrogel can be in various physical forms such a sheet, foam, or plurality of pieces. Also described are methods of forming a fibrin article, wound dressings and a method of treatment of a wound.

A system for monitoring at least one characteristic of biological material of an individual includes a wearable product. The wearable product includes an outer surface and a skin contact surface defining an internal area. An analysis portal is disposed in the internal area, and includes a sensing portion and an investigation portion. The sensing portion has at least one sensor, and the investigation portion that includes a computing device having a health screener. The sensing portion of the analysis portal comes into contact with a biological material of the individual, and the health screener is configured to determine at least one characteristic of the biological material. The computing device is communicatively coupled to the sensors and the display.

A method of preparing a wound dressing includes coating a support layer with an adhesive layer and forming a pattern of depressions in the adhesive layer on an edge portion of the wound dressing, with the pattern of depressions being in the adhesive layer and not penetrating the support layer. The method includes forming a plurality of through-going holes in a central portion of the wound dressing, with the through-going holes penetrating both the support layer and the adhesive layer and each of the plurality of through-going holes at least as large in the support layer as in the adhesive layer.

Embodiments of the present invention relate generally to the field of tissue repair and regeneration. More specifically, embodiments of the present invention relate to medical devices, materials or constructs, such as conductive biocompatible polymers having one or more networks of metal nanowires that enhance tissue repair and regeneration using electromagnetic fields.

The present invention is directed to a hemostatic textile, comprising: a material comprising a combination of glass fibers and one or more secondary fibers selected from the group consisting of silk fibers; ceramic fibers; raw or regenerated bamboo fibers; cotton fibers; rayon fibers; linen fibers; ramie fibers; jute fibers; sisal fibers; flax fibers; soybean fibers; corn fibers; hemp fibers; lyocel fibers; wool; lactide and/or glycolide polymers; lactide/glycolide copolymers; silicate fibers; polyamide fibers; feldspar fibers; zeolite fibers, zeolite-containing fibers, acetate fibers; and combinations thereof; the hemostatic textile capable of activating hemostatic systems in the body when applied to a wound. Additional cofactors such as thrombin and hemostatic agents such as RL platelets, RL blood cells; fibrin, fibrinogen, and combinations thereof may also be incorporated into the textile. The invention is also directed to methods of producing the textile, and methods of using the textile to stop bleeding.

Systems, methods, and apparatuses arc presented that involve forming patterns on neo-epithelium that allow increased functionality and may more nearly resemble the original epithelium. In one instance, a patterned neo-epithelium dressing for treating a tissue site having granulation tissue includes an interface member for placing proximate the granulation tissue and a plurality of three-dimensional features formed on a second, patient-facing side of the interface member. Other systems, methods, and apparatuses are disclosed.