Devices, kits and methods described herein are be used at chronic injection site or in conjunction with an indwelling catheter or cannula. A book-like packaging, applicator and/or tensioning device with an opening and optional indicia to align the catheter or cannula to the opening may be used to apply a dressing to a subject. The packaging, applicator and/or tensioning device may apply and/or maintain a strain in an elastic dressing.

An adhesive convertible tissue stabilizer is provided which can be applied preoperatively to a patient to retract tissue to facilitate a medical/surgical procedure. As a perioperative device, the convertible device accepts most, if not all, surgical preparations, enabling the creation of a sterile field. At the completion of the procedure, the convertible device is converted from a perioperative device to a post-operative device by removal of a layer of the convertible device.

Systems, apparatuses, and methods for providing negative pressure and/or instillation fluids to a tissue site are disclosed. Some embodiments are illustrative of an apparatus or system for delivering negative-pressure and/or therapeutic solution of fluids to a tissue site, which can be used in conjunction with sensing properties of fluids extracted from a tissue site and/or instilled at a tissue site. For example, an apparatus may comprise a dressing interface or connector that includes a pH sensor, a humidity sensor, a temperature sensor and/or a pressure sensor embodied on a single pad within the connector and proximate the tissue site to provide data indicative of acidity, humidity, temperature and pressure. Such apparatus may further comprise algorithms for processing such data for detecting leakage and blockage as well as providing information relating to the progression of healing of wounds at the tissue site. An illustrative method may comprise positioning a dressing interface having a pH sensor, a temperature sensor, a humidity sensor, and a pressure sensor at a tissue site, and applying reduced pressure to the dressing interface to draw fluids from the tissue interface in contact with the sensors to sense the pH, temperature, humidity, and pressure properties of the fluids flowing from the tissue site. The method may further comprise providing fluid data indicative of such properties to a processing element for processing the fluid data, and transmitting the data to another component in the system.

The present invention relates to large scale manufacture of nanoscale microsheets for use in applications such as wound healing or modification of a biological or medical surface.

A medical dressing is described that includes: a porous layer having a first side and a second side; a first coating extending along at least a portion of the surface area of said first side of said porous layer; a second coating extending along said first side of said porous layer, said second coating comprising a pattern of through openings; wherein said first coating extends along at least those portions of the surface area of said first side of said porous layer that coincide with the through openings of said second coating and wherein said first surface of said second coating extends in a plane (B) that is farther away, in the vertical direction, from the first side of said porous layer, than the corresponding plane (A) defined by the first surface of said first coating.

A bandage configured to be administered from a continuous roll, comprising: (I) a first layer of flexible webbed material, the first layer including a self-adhesive disposed on a top surface; and (II) a second layer of flexible padded material adhered to the first layer along a longitudinal axis by the self-adhesive, the second layer having a width less than a width of the first layer so that a portion of the self-adhesive is exposed on each longitudinal side of the second layer; wherein the self-adhesive may releasably adhere to a bottom surface of the first layer in a rolled form so that, when unrolled, an adhesive bond is broken free of damaging the first layer; and wherein, when the self-adhesive is bonded to itself and opposing adhesive portions, the resulting peel strength is greater than a peel strength when the self-adhesive is bonded to skin.

Adhesive hot-melt formulations with a main polymeric component, of at least one isotactic metallocene butene-1 polymer composition, that has a low viscosity, and that has a bimodal composition, directly obtained during polymerization, in two consecutive and separate reaction steps. Moreover, said hot-melts include less than 5% by weight of at least one viscosity modifier that is not solid at room temperature. Such unusually low level of said additives, surprisingly allows to attain substantially improved levels both of high adhesiveness and cohesion. The adhesive hot-melt formulations include less than 5% by weight of a polyethylene wax or of a blend of polyethylene waxes, that characterized by a highly linear/non-branched structure and by an exceptionally low Polydispersity Index. The presence of such peculiar polyethylene waxes, that are partially incompatible with the butene-1 polymer composition, allows to use the disclosed hot-melt formulations even in the presence of fibrous or perforated substrates.

A neurosurgical ultrasonic focusing assisted three-stage atomization cooling and postoperative wound film forming device has a transducer housing and a nozzle, wherein a horn is arranged in the transducer housing, at least two layers of piezoelectric ceramic sheets are arranged at the top of the horn, an electrode sheet connected with an ultrasonic generator is arranged between two adjacent layers of piezoelectric ceramic sheets, the bottom of the transducer housing is of a hemispherical structure, and a plurality of piezoelectric elements connected with the ultrasonic generator are arranged inside the hemispherical structure; and the nozzle is arranged at the bottom of the horn and connected with a medical nanofluid storage cup, compressed gas can also be introduced into the nozzle, and an electrode is also arranged inside the nozzle.

A negative pressure wound closure system and methods for using such a system are described. Preferred embodiments of the invention facilitate closure of the wound by utilizing a stabilizing structure that preferentially contracts to provide for movement of the tissue. Some embodiments may utilize a protective layer, such as a mesh or net layer, attached to a top surface of the stabilizing structure. The protective layer prevents a drape positioned over the stabilizing structure from being drawn into cells of the stabilizing structure, and permits visualization of the collapse of the cells.

A barrier layer and corresponding method of making provide anti-inflammatory, non-inflammatory, and anti-adhesion functionality for a medical device implantable in a patient. The barrier layer can be combined with a medical device structure to provide anti-adhesion characteristics, in addition to improved healing, non-inflammatory, and anti-inflammatory response. The barrier layer is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent.