The invention provides a method for isolating medical isotopes, the method having the steps of dissolving titanium nuclear targets to create a solution; contacting the solution with a resin so as to retain the isotopes on the resin and generate an eluent containing titanium; contacting the isotope-containing resin with acid of a first concentration to remove impurities from the resin; and contacting the isotope-containing resin with an acid of a second concentration to remove isotope from the resin.

Disclosed herein are embodiments of a method for producing thorium-226. The method comprises separating thorium-226 from uranium-230 to produce a solution of thorium-226 in a solvent, such as a chelating buffer, suitable for direct labeling by a chelate. The thorium-226 may be separated from the uranium-230 using extraction chromatography. The extraction may be repeated multiple times as additional thorium-226 is produced by uranium-230 decay.

Separators configured to create and use thin fluid layers, tubes, channels, or streams, multi-port collections, and one or more forces to separate and recover elements, molecules, ions, isotopes, and particles (entities). The separators include a support. The support may include inclined surfaces, rotatable cylinders, channels, tubes, streams or sets thereof. The separators may allow for the creation of a thin fluid layer or stream on the surface of the support or on a collection of small tubes, channels, or streams by dispensing a fluid onto the surface or collection of tubes, channels, or streams. Depending on properties of the entities to be separated, the separators can include a force application device configured to subject the entities to a magnetic field, an electrical and/or electrostatic field, a centrifugal field, an electrolytic field, an oscillating field, a hydrophobic gradient, a hydrophilic gradient, or a concentration gradient to facilitate the separations.

Separators configured to create and use thin fluid layers, tubes, channels, or streams, multi-port collections, and one or more forces to separate and recover elements, molecules, ions, isotopes, and particles (entities). The separators include a support. The support may include inclined surfaces, rotatable cylinders, channels, tubes, streams or sets thereof. The separators may allow for the creation of a thin fluid layer or stream on the surface of the support or on a collection of small tubes, channels, or streams by dispensing a fluid onto the surface or collection of tubes, channels, or streams. Depending on properties of the entities to be separated, the separators can include a force application device configured to subject the entities to a magnetic field, an electrical and/or electrostatic field, a centrifugal field, an electrolytic field, an oscillating field, a hydrophobic gradient, a hydrophilic gradient, or a concentration gradient to facilitate the separations.

The invention provides a method for isolating medical isotopes, the method having the steps of dissolving titanium nuclear targets to create a solution; contacting the solution with a resin so as to retain the isotopes on the resin and generate an eluent containing titanium; contacting the isotope-containing resin with acid of a first concentration to remove impurities from the resin; and contacting the isotope-containing resin with an acid of a second concentration to remove isotope from the resin.

In one aspect, a microfluidic device, system, and method for separating and purifying radioisotopes is disclosed. The microfluidic device may comprise an inlet channel stream, an outlet channel stream, and a junction. The inlet channel stream, the outlet channel stream, and the junction may be in fluid communication.

In one aspect, a microfluidic device, system, and method for separating and purifying radioisotopes is disclosed. The microfluidic device may comprise an inlet channel stream, an outlet channel stream, and a junction. The inlet channel stream, the outlet channel stream, and the junction may be in fluid communication.

An apparatus for producing Pb-212. The apparatus comprises an emanation box that comprises an emanation source comprising a porous non-reactive material. The emanation box receives at least one of Th-228 and Ra-224, wherein the at least one of Th-228 and Ra-224 decays to Rn-220 within the emanation box. The apparatus further includes a carrier gas feed coupled to the emanation box. The carrier gas feed directs an inert gas into the emanation box and the inert gas carries the Rn-220 out of the emanation box through a carrier gas exit port of the emanation box. The apparatus also includes one or more Rn-220 targets coupled to the carrier gas exit port. The carrier gas carries the Rn-220 from the emanation box to the one or more Rn-220 targets and the Rn-220 decays into Pb-212 within the one or more Rn-220 targets. The Pb-212 is directed into the Pb-212 collection container.

Provided is a backflow cascade novel process for producing a lithium-7 isotope. The process comprises an upper backflow section, an extraction section, an enrichment section, a lower backflow section, and a product acquiring section. Upper backflow phase-conversion liquid and lower backflow phase-conversion liquid are respectively added to the upper backflow section and the lower backflow section, and upper backflow phase-conversion liquid and lower backflow phase-conversion liquid of the lithium material are controlled; the product is precisely acquired in the product acquiring section; an organic phase is added to the upper backflow section, and is recycled in the lower backflow section. By means of cascade connection with a high-performance liquid separator, environmental protection, high efficiency, and multi-level enrichment of the lithium-7 isotope are achieved, and a high-abundance lithium-7 isotope product is obtained.

Provided is a backflow cascade novel process for producing a lithium-7 isotope. The process comprises an upper backflow section, an extraction section, an enrichment section, a lower backflow section, and a product acquiring section. Upper backflow phase-conversion liquid and lower backflow phase-conversion liquid are respectively added to the upper backflow section and the lower backflow section, and upper backflow phase-conversion liquid and lower backflow phase-conversion liquid of the lithium material are controlled; the product is precisely acquired in the product acquiring section; an organic phase is added to the upper backflow section, and is recycled in the lower backflow section. By means of cascade connection with a high-performance liquid separator, environmental protection, high efficiency, and multi-level enrichment of the lithium-7 isotope are achieved, and a high-abundance lithium-7 isotope product is obtained.