The present invention relates to a method for removing biopolymer aggregates and viruses from a fluid. In a first step, the biopolymer aggregates are selectively removed by filtration through a porous, polyamide-comprising shaped body having a native surface. In a second step, the biopolymer aggregate-free fluid is filtered through at least one suitable virus-retentive membrane.

Disclosed here includes a method for purifying a biologic composition, comprising diafiltering the biologic composition into a composition comprising phosphate buffered saline (PBS) to obtain a purified composition. The method disclosed here can be particularly useful for removing one or more impurities from the biologic composition, such as bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane (Bis-tris).

Disclosed here includes a method for purifying a biologic composition, comprising diafiltering the biologic composition into a composition comprising phosphate buffered saline (PBS) to obtain a purified composition. The method disclosed here can be particularly useful for removing one or more impurities from the biologic composition, such as bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane (Bis-tris).

Separators for separating a multi-phase composition include a separator casing defining a chamber and a permeate outlet, at least one hydrocyclone within the separator casing, and at least one ceramic membrane. Each hydrocyclone includes a hydrocyclone inlet, a tapered section downstream of the hydrocyclone inlet, an accepted outlet, and a reject outlet. The ceramic membrane may be disposed within the separator casing and downstream of the accepted outlet of the hydrocyclone or may be disposed within at least a portion of the tapered section of the hydrocyclone. The ceramic membrane includes a retentate side and a permeate side, where the permeate side is in fluid communication with the chamber. Systems and methods for separating a multi-phase composition into a lesser-density fluid, a greater-density fluid, and a medium-density fluid using the separators are also disclosed.

Separators for separating a multi-phase composition include a separator casing defining a chamber and a permeate outlet, at least one hydrocyclone within the separator casing, and at least one ceramic membrane. Each hydrocyclone includes a hydrocyclone inlet, a tapered section downstream of the hydrocyclone inlet, an accepted outlet, and a reject outlet. The ceramic membrane may be disposed within the separator casing and downstream of the accepted outlet of the hydrocyclone or may be disposed within at least a portion of the tapered section of the hydrocyclone. The ceramic membrane includes a retentate side and a permeate side, where the permeate side is in fluid communication with the chamber. Systems and methods for separating a multi-phase composition into a lesser-density fluid, a greater-density fluid, and a medium-density fluid using the separators are also disclosed.

The present disclosure provides a process for concentrating proteins including an ultrafiltering, a diafiltering, and a second ultrafiltering sequence, at elevated temperatures, such as above about 30° C. The disclosure also includes a process for preparing highly concentrated antibody compositions, and highly concentrated antibody products.

The present disclosure provides a process for concentrating proteins including an ultrafiltering, a diafiltering, and a second ultrafiltering sequence, at elevated temperatures, such as above about 30° C. The disclosure also includes a process for preparing highly concentrated antibody compositions, and highly concentrated antibody products.

Disclosed are methods of treating wastewater using a membrane bioreactor and achieving a target phosphorus concentration for the membrane permeate stream. These methods include the steps of dosing a wastewater stream with a rare earth clarifying agent and passing the dosed wastewater stream through the membrane to obtain a membrane permeate stream with a permeate concentration that is less than the phosphorus concentration of the influent stream. This permeate concentration also can be equal to or less than a target phosphorus concentration. In the methods as disclosed herein, the rare earth clarifying agent can be chloride salts of one or more rare earth elements and in certain embodiments, the rare earth clarifying agent can be CeCl.sub.3 and LaCl.sub.3.

Disclosed are methods of treating wastewater using a membrane bioreactor and achieving a target phosphorus concentration for the membrane permeate stream. These methods include the steps of dosing a wastewater stream with a rare earth clarifying agent and passing the dosed wastewater stream through the membrane to obtain a membrane permeate stream with a permeate concentration that is less than the phosphorus concentration of the influent stream. This permeate concentration also can be equal to or less than a target phosphorus concentration. In the methods as disclosed herein, the rare earth clarifying agent can be chloride salts of one or more rare earth elements and in certain embodiments, the rare earth clarifying agent can be CeCl.sub.3 and LaCl.sub.3.

A zero-sugar and zero-net carb dairy product includes a washed fermented dairy material. Separation technology for the removal of sugars and organic acids from a fermented dairy material to produce the zero-sugar and zero-carb dairy product includes the repetition of a wash cycle involving a dilution step and a separation step. The separation technology achieves at least an 60% reduction in total sugars, at least an 80% reduction in organic acids and at least a 60% reduction in total carbohydrates. The zero-sugar and zero-net carb dairy product has a protein to carbohydrate ratio at least double that of conventional low-carb dairy products.