The invention discloses a first unit (1) for treatment of a bioprocess liquid comprising a first lateral face (2), a second lateral face (3) and a front face (4) which meets the two said lateral faces. The front face comprises: a plurality of valves (7) adapted to receive and act upon one or more legs (8) of a disposable flow path (6); optionally one or more pumps (10) adapted to receive and act upon one or more legs of the disposable flow path; optionally one or more sensors (11) adapted to receive and to measure one or more parameters in one or more legs of the disposable flow path; wherein the plurality of valves and optional pumps and sensors are vertically offset from each other to give one or more legs of a disposable flow path received by said valves and optional pumps and sensors a slope of at least 3.0 degrees from the horizontal plane (h).

The invention discloses a first unit (1) for treatment of a bioprocess liquid comprising a first lateral face (2), a second lateral face (3) and a front face (4) which meets the two said lateral faces. The front face comprises: a plurality of valves (7) adapted to receive and act upon one or more legs (8) of a disposable flow path (6); optionally one or more pumps (10) adapted to receive and act upon one or more legs of the disposable flow path; optionally one or more sensors (11) adapted to receive and to measure one or more parameters in one or more legs of the disposable flow path; wherein the plurality of valves and optional pumps and sensors are vertically offset from each other to give one or more legs of a disposable flow path received by said valves and optional pumps and sensors a slope of at least 3.0 degrees from the horizontal plane (h).

A near-zero maintenance integrated purification device for drinking water supply of villages and towns and a method for treating source water using this device are provided to solve the multi-pollution problems caused by microorganisms, turbidity, iron, manganese, taste and odor, and organic matter in the drinking water sources of villages and towns. The device includes a small-spacing folding plate speed sink regulating water tank, a small diameter tube reactor, a granular active carbon (GAC) slow-speed filter tank, a gravity-driven ultrafiltration membrane tank and an ipsilateral U-turn corridor clean water tank. The near-zero maintenance integrated purification device is applicable to different types of water sources (e.g., groundwater, lake water, reservoir water, spring water, snowmelt water, cellar water and rain water, etc.), and could efficiently remove kinds of pollutants, improving the biological and chemical safety of drinking water.

A near-zero maintenance integrated purification device for drinking water supply of villages and towns and a method for treating source water using this device are provided to solve the multi-pollution problems caused by microorganisms, turbidity, iron, manganese, taste and odor, and organic matter in the drinking water sources of villages and towns. The device includes a small-spacing folding plate speed sink regulating water tank, a small diameter tube reactor, a granular active carbon (GAC) slow-speed filter tank, a gravity-driven ultrafiltration membrane tank and an ipsilateral U-turn corridor clean water tank. The near-zero maintenance integrated purification device is applicable to different types of water sources (e.g., groundwater, lake water, reservoir water, spring water, snowmelt water, cellar water and rain water, etc.), and could efficiently remove kinds of pollutants, improving the biological and chemical safety of drinking water.

Filtration apparatus for the assay of biological and biochemical reactants, for example, is provided and includes a substrate such as a plate having one or more wells open at each end, and a porous membrane positioned in each well forming a discrete filtering area. The filtration apparatus includes a seal that is in a compressible relationship with the face of the porous membrane, the surface of the compression element, and the well wall. Each well includes a compression element, such as an internal well insert or sleeve, which compresses the seal so that the seal contacts the membrane face, the surface of the compression element, and the well wall in a liquid-tight manner. The compression element may be configured so that it is fixed in the well such as by an interference fit with the well wall or by bonding to a surface of the substrate.

Filtration apparatus for the assay of biological and biochemical reactants, for example, is provided and includes a substrate such as a plate having one or more wells open at each end, and a porous membrane positioned in each well forming a discrete filtering area. The filtration apparatus includes a seal that is in a compressible relationship with the face of the porous membrane, the surface of the compression element, and the well wall. Each well includes a compression element, such as an internal well insert or sleeve, which compresses the seal so that the seal contacts the membrane face, the surface of the compression element, and the well wall in a liquid-tight manner. The compression element may be configured so that it is fixed in the well such as by an interference fit with the well wall or by bonding to a surface of the substrate.

The present invention provides, in various embodiments, hybrid single-pass tangential flow filtration assemblies, disposable single-pass tangential flow filtration assemblies, scalable single-pass tangential flow filtration assemblies and adaptable modular single-pass tangential flow filtration assemblies. In other embodiments, the invention relates to processes for recovering proteins from the surface of a filtration membrane in a single-pass tangential flow filtration assembly and for cleaning a tangential flow filtration assembly. In additional embodiments, the invention provides methods of increasing the processing capacity of a single-pass tangential flow filtration assembly.

The present invention provides, in various embodiments, hybrid single-pass tangential flow filtration assemblies, disposable single-pass tangential flow filtration assemblies, scalable single-pass tangential flow filtration assemblies and adaptable modular single-pass tangential flow filtration assemblies. In other embodiments, the invention relates to processes for recovering proteins from the surface of a filtration membrane in a single-pass tangential flow filtration assembly and for cleaning a tangential flow filtration assembly. In additional embodiments, the invention provides methods of increasing the processing capacity of a single-pass tangential flow filtration assembly.

A system for separating competing anions from per- and polyfluoroalkyl substances (PFAS) in a flow of water contaminated with PFAS and elevated levels of competing anions that includes a separation subsystem which receives the flow of water contaminated with PFAS and elevated levels of competing anions and separates competing anions from the PFAS and concentrates the PFAS to produce a treated flow of water having separated competing anions therein and a flow of water having a majority of PFAS therein. At least one anion exchange vessel having an anion exchange resin therein receives the flow of water having a majority of PFAS therein and removes PFAS from the water to produce a flow of treated water having a majority of the PFAS removed. The separation of competing anions by the separation subsystem increases the treatment capacity of the anion exchange resin to remove PFAS from the contaminated water.

To provide biotechnological filtration possibilities with which the danger of contamination is low and at the same time an optimum flow profile can be achieved, the use of a filter module 100 is proposed, the latter having, in a filter housing 110, a filter, with a bundle of hollow fibres 114, and a centrifugal pump rotor 132, for a biotechnological production method, and a filter module 100 for the filtration of a biotechnological liquid L, having a filter housing 110, a filter arranged in the filter housing 110 with a bundle of hollow fibres 114, a centrifugal pump rotor 132 arranged in the filter housing 110 such that it is fluidically connected to the interior of the hollow fibres 114, wherein the centrifugal pump rotor 132 is able to be magnetically driven such that it can force a liquid L through the hollow fibres 114, a first port 102 for the supply of a biotechnological liquid L to be filtered, which first port 102 is fluidically connected to the interior of the hollow fibres 114 of the filter, a second port 104 for the removal of a biotechnological liquid L to be filtered, which second port 104 is fluidically connected to the interior of the hollow fibres 114 of the filter, and a third port 107 for the removal of precipitated waste liquid, which third port 107 is fluidically connected to the exterior of the hollow fibres 114, and a filtration device 1100, 1200, 1300 having a filter module 100, which is able to be coupled to a drive unit, and a drive unit for magnetically driving the centrifugal pump rotor 132 of the filter module 100, which drive unit can generate dynamic magnetic fields for magnetically driving and magnetically supporting the centrifugal pump rotor 132 when the filter module 100 is coupled to the drive module.