A dialysis machine comprising: a first sensor for detecting motion of a patient; a second sensor for detecting a health condition of the patient; a processing module for: controlling dialysis functions of a dialysis treatment; receiving information related to a status of the dialysis treatment in which toxins are removed from blood of the patient; receiving, from the first sensor, information related to the motion of the patient; receiving, from the second sensor, information related to the health condition of the patient; and identifying an emergency condition based at least in part on the information related to the motion of the patient, the information related to the health condition of the patient, and the information related to the status of the dialysis treatment; and a transceiver for: in response to identifying an emergency condition, sending a notification that includes patient information to one or more remote entities.

A dialysis machine comprising: a first sensor for detecting motion of a patient; a second sensor for detecting a health condition of the patient; a processing module for: controlling dialysis functions of a dialysis treatment; receiving information related to a status of the dialysis treatment in which toxins are removed from blood of the patient; receiving, from the first sensor, information related to the motion of the patient; receiving, from the second sensor, information related to the health condition of the patient; and identifying an emergency condition based at least in part on the information related to the motion of the patient, the information related to the health condition of the patient, and the information related to the status of the dialysis treatment; and a transceiver for: in response to identifying an emergency condition, sending a notification that includes patient information to one or more remote entities.

A disposable cartridge for use in a hemodialysis machine has a blood flow path for carrying a volume of blood to be treated in a dialyser and a dialysate flow path, isolated from the blood flow path, for delivering a flow of dialysate solution through the dialyser. The cartridge is received in an engine section of the machine. The engine section has first and second platens which close when the cartridge is inserted to retain the cartridge. Actuators and sensors arranged on the second platen control operation of the cartridge.

The present invention relates to an injectable homogeneous aqueous solution of chitosan containing, in a physiologically acceptable medium, between 0.1 and 4.5% by weight of a chitosan having a degree of acetylation less than 20% and a weight average molecular mass of between 100,000 and 1,500,000 g/mol, said solution having a pH greater than or equal to 6.2, and advantageously between 6.2 and 7.2, said solution not containing any chitosan having a degree of acetylation greater than 20%, said solution being liquid and homogeneous at ambient temperature. The invention also relates to an aqueous solution such as previously described, characterised in that it can be prepared by a method comprising at least the following steps: dissolving the chitosan in water by adding acid, such as a weak acid, said weak acid being advantageously chosen from the group consisting of acetic acid, glycolic acid, lactic acid, glutamic acid, and the mixtures of same, and readjusting the pH by dialysis, preferably at ambient temperature, in order to obtain an aqueous solution having a pH greater than or equal to 6.2, advantageously between 6.2 and 7.2, and preferably between 6.25 and 7.1.

A means capable of simply and efficiently concentrating a cell suspension. A concentrator has a culture vessel having a first port and a second port, a server bag having a port, a case having a hollow fiber bundle in the internal space, a filtering device having an inlet port, a first outlet port, and a second outlet port, a collection vessel having a port, a liquid supply circuit connected to the first port, the inlet port, and the server bag's port so that flow passages are switchable, a liquid discharge circuit connected to the second port, the first outlet port, the second outlet port, and the collection vessel's port so that flow passages are switchable, a liquid supply mechanism having a switching mechanism, a supply pump, and a discharge pump, and a rotation mechanism rotating the filtering device.

A purification method for a biological fluid comprising at least a filtration step through a membrane obtained from a sulfone polymer (PSI) derived from bio-based feed-stocks. In particular the polymer (PSI) comprises more than 50% moles recurring units (R.sub.PSI) comprising sugar moieties selected from the group consisting of those of formulae (E-I) to (E-III):

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A membrane free from pore-forming agents comprising at least one sulfone polymer (PSI) and a method for preparing such a membrane.

The present disclosure relates to a hemodialysis membrane for the treatment of vascular calcification in hemodialysis patients, especially in chronic hemodialysis patients. The present disclosure further relates to methods of treating vascular calcification in hemodialysis patients, wherein the hemodialysis membrane is characterized in that it comprises at least one hydrophobic polymer and at least one hydrophilic polymer and in that it has a MWRO of between 15 and 20 kD and a MWCO of between 170-320 kD or that the hemodialysis membrane comprises at least one hydrophobic polymer and at least one hydrophilic polymer and has a MWRO of between 8.5 kD and 14.0 kD and a MWCO of between 55 kD and 130 kD.

The invention provides a method for the continuous, microbe-reduced production and/or processing of a biopharmaceutical, biological macromolecular product from a heterogeneous cell culture-fluid mixture, comprising the steps of: (a) providing a particle-free fluid from a heterogeneous cell culture-fluid mixture containing the product, in the form of a product stream, (b) at least one filtration, providing a filtrate, (c) at least two chromatography steps for purifying the product, (d) at least one virus depletion, (e) at least one ultrafiltration and/or at least one diafiltration of the product stream of steps (b), (c) and/or (d), characterized in that the at least two chromatography steps from (c) comprise a purification via at least two chromatography columns and/or membrane adsorbers in each case and that the process is carried out in a closed and modular manner The invention further provides a corresponding modular system for carrying out said method.

The present disclosure relates to a dialysis apparatus comprising a membrane having at least one protein from the lipocalin family bound thereon. The disclosure further relates to methods of removing non-polar, hydrophobic and/or protein bound uremic toxins from a target subject utilizing the dialysis apparatus described herein as well as methods of extracorporeal detoxification.

A method for filtering blood is disclosed that in one embodiment includes the steps of depositing unfiltered blood along at least one side of a semi-permeable surface having multiple pores, depositing target tissue along at least an opposing side of the semi-permeable surface, and permitting the unfiltered blood to flow at least partially along the semi-permeable surface to filter the unfiltered blood. Embodiments of the invention can remove self-directed autoantibodies from the blood while reducing the complications of conventional treatments such as plasmaphoresis, and return the patient's own blood cells and its plasma components, less the disease-causing self-directed antibodies. A blood filter and a blood bag are also disclosed.