An extracorporeal blood treatment apparatus having a fluid system and a pump for conveying fluid in the fluid system, wherein the pump is a non-occluding pump, and a method for shutting off or reducing the speed of rotation of a non-occluding pump in a fluid system of an extracorporeal blood treatment apparatus. The apparatus and the method are characterized in that before the speed of rotation is reduced or the pump is shut off, the fluid flow into the feed line and out of the discharge line is first interrupted, and after a predetermined time interval after interruption of the fluid flow has elapsed, the speed of rotation of the pump is reduced or the pump is shut off. The time-delayed shut-off of the pump prevents a reverse flow of fluid, particularly of blood into the arterial blood line, even in the absence of occlusion. As a result of the time-delayed shut-off or reduction in the speed of rotation of the pump, however, an excess pressure is produced in the fluid system. Therefore the blood treatment apparatus and the method provide for counter-measures to prevent uncontrolled fluid flow when the shut-off elements are opened, due to the excess pressure.

An extracorporeal blood treatment apparatus having a fluid system and a pump for conveying fluid in the fluid system, wherein the pump is a non-occluding pump, and a method for shutting off or reducing the speed of rotation of a non-occluding pump in a fluid system of an extracorporeal blood treatment apparatus. The apparatus and the method are characterized in that before the speed of rotation is reduced or the pump is shut off, the fluid flow into the feed line and out of the discharge line is first interrupted, and after a predetermined time interval after interruption of the fluid flow has elapsed, the speed of rotation of the pump is reduced or the pump is shut off. The time-delayed shut-off of the pump prevents a reverse flow of fluid, particularly of blood into the arterial blood line, even in the absence of occlusion. As a result of the time-delayed shut-off or reduction in the speed of rotation of the pump, however, an excess pressure is produced in the fluid system. Therefore the blood treatment apparatus and the method provide for counter-measures to prevent uncontrolled fluid flow when the shut-off elements are opened, due to the excess pressure.

The present disclosure relates to an artificial, extracorporeal system for supporting the function of the liver of a patient suffering from liver failure, which is characterized in that it comprises a first high-flux or high cut-off hollow fiber membrane dialyzer which is perfused on the lumen side with the patient's blood and wherein a buffered aqueous solution comprising human serum albumin is passed in a continuous flow through the filtrate space of said first dialyzer, a second hollow fiber membrane dialyzer which removes water-soluble substances from the dialysate of said first dialyzer, and a third, integrated hollow fiber membrane dialyzer which is perfused with the retentate of second hemodialyzer and which allows the passage of certain amounts of albumin over the membrane wall into the filtrate space which is populated with adsorbent material. The system can be used for the treatment of acute liver failure and acute-on-chronic liver failure.

The present disclosure relates to an artificial, extracorporeal system for supporting the function of the liver of a patient suffering from liver failure, which is characterized in that it comprises a first high-flux or high cut-off hollow fiber membrane dialyzer which is perfused on the lumen side with the patient's blood and wherein a buffered aqueous solution comprising human serum albumin is passed in a continuous flow through the filtrate space of said first dialyzer, a second hollow fiber membrane dialyzer which removes water-soluble substances from the dialysate of said first dialyzer, and a third, integrated hollow fiber membrane dialyzer which is perfused with the retentate of second hemodialyzer and which allows the passage of certain amounts of albumin over the membrane wall into the filtrate space which is populated with adsorbent material. The system can be used for the treatment of acute liver failure and acute-on-chronic liver failure.

A dialyzer and a fabricating method thereof are provided. The dialyzer includes a housing, a hydrophilic layer, a fixing layer, a plurality of hollow fiber membranes, and two end caps. The housing has a first opening and a second opening, and is provided with a dialysate inlet and a dialysate outlet, wherein an entire peripheral surface of the housing located between the first opening and the dialysate inlet is a first portion, and an entire peripheral surface of the housing located between the second opening and the dialysate outlet is a second portion. The hydrophilic layer is disposed on the inner wall of the first portion and the second portion, wherein the hydrophilic layer and the housing are different materials. The fixing layer is disposed on the hydrophilic layer and fixes the hollow fiber membranes to the inner wall of the housing.

An end cap of a dialyzer and a fabricating method thereof, and a dialyzer are provided. The end cap includes a main body and a sealing element. The main body has a blood port. The sealing element is integrally connected on an inner wall of the main body.

A method of measuring concentration of dissolved organic nitrogen in sewage. The method includes: filtering a sewage sample using a filter membrane; measuring the concentrations of total dissolved nitrogen (TDN), ammonia nitrogen (NH.sub.4.sup.+), and nitric nitrogen (NO.sub.3.sup.) in the sewage sample, respectively designated as C.sub.TDN(I), C.sub.NH4.sup.+.sub.(I) and C.sub.NO3.sup..sub.(I); calculating the ratios of (C.sub.NH4.sup.+.sub.(I)+C.sub.NO3.sup..sub.(I))/C.sub.TDN(I) and C.sub.NO3.sup..sub.(I)/C.sub.NH4.sup.+.sub.(I), and according to the ratios, calculating the concentration of dissolved organic nitrogen (DON) in the sewage sample.

A hose mount of a blood treatment machine, having a hose connection element as a component of the machine's internal hosing including at least one rigid sleeve portion that is adapted to position a flexible hose radially outside over the free end of the at least one sleeve portion, an axial stop formed or arranged on the outer circumference of the sleeve portion at a distance from the free end, and a flexible collar arranged or formed on the at least one sleeve element toward the free end with an axial distance to the axial stop in order to define an external circumferential groove between itself and the axial stop.

A hose mount of a blood treatment machine, having a hose connection element as a component of the machine's internal hosing including at least one rigid sleeve portion that is adapted to position a flexible hose radially outside over the free end of the at least one sleeve portion, an axial stop formed or arranged on the outer circumference of the sleeve portion at a distance from the free end, and a flexible collar arranged or formed on the at least one sleeve element toward the free end with an axial distance to the axial stop in order to define an external circumferential groove between itself and the axial stop.

Parallel plate devices for hemofiltration or hemodialysis are provided. A parallel plate device includes a parallel plate assembly having an aligned stack of stackable plate subunits, each stackable plate subunit having a through channel for blood, where the blood channels are opened up at opposite ends of the parallel plate assembly. The parallel plate assembly is configured to form filtrate/dialysate channels interleaved with the blood channels, adjacent channels being separated by a silicon nanoporous filtration membrane. A blood conduit adaptor is attached to the parallel plate assembly at each of the ends, and is configured to distribute blood to or collect blood from the blood channels. Also provided are systems and methods for using the parallel plate devices.